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“…The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. …”
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“…Sepsis treatment includes antibacterial therapy, support of host vital functions and restore of homeostasis. …”
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“…Recent studies uncovered an important role of MDSCs in the pathogenesis of infectious diseases along with sepsis. Here we discuss the mechanisms underlying the expansion and immunosuppressive functions of MDSCs, and the results of preclinical and clinical studies linking MDSCs to sepsis pathogenesis. …”
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“…In April 2018, the Surviving Sepsis Campaign (SSC) released an updated sepsis bundle, which combines directives previously listed in the three-hour and six-hour bundles. …”
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“…This has contributed significantly to the overall improved outcomes with sepsis. Investigation into clinically relevant biomarkers of sepsis are ongoing and have yet to yield effective results. …”
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“…The systemic consequences of sepsis have been intensively examined and evidences of local alterations and repercussions in the intestinal mucosal compartment is gradually defining gut-associated changes during sepsis. …”
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“…Sepsis is one of the leading causes of deaths world-wide and yet there are no therapies available other than ICU treatment. …”
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“…BACKGROUND: Sepsis is a highly lethal disorder. Organ dysfunction in sepsis is not defined as a clinicopathological entity but rather by changes in clinical, physiological, or biochemical parameters. …”
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“…The critical role of platelets during sepsis and the therapeutic implications are also reviewed.…”
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“…This review initially summarizes the HIF-driven changes in metabolic dynamics of innate immune cells in response to sepsis. The hyperinflammatory phase of sepsis is accompanied by a metabolic switch from oxidative phosphorylation to HIF-1α mediated glycolysis. …”
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“…BACKGROUND: Sepsis is a severe, life-threatening illness in response to an infection from the body’s immune system. …”
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“…In this case report, a one-day-old, preterm, male baby (26 weeks of gestation) was referred for preterm care. A sepsis-induced leukemoid reaction hyperleukocytosis diagnosis was presumed, and he was successfully treated with an empirical antibiotic with a gradual improvement in WBC counts.…”
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“…Mystery of PCO(2) Gap in Sepsis. Indian J Crit Care Med 2019;23(10):443–444.…”
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“…These organelles also release reactive oxygen species (ROS), which are normal byproducts of metabolism at physiological levels; however, overproduction of ROS under pathophysiological conditions is considered part of a disease process, as in sepsis. The inflammatory response inherent in sepsis initiates changes in normal mitochondrial functions that may result in organ damage. …”
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“…Sepsis is, in many patients, very difficult to recognise, especially early on and in the elderly and those with multiple comorbidities(1). …”
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“…Although the treatment of sepsis has developed rapidly in the past few years, sepsis incidence and mortality in clinical treatment is still climbing. …”
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