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“…Sepsis still remains a challenging healthcare problem with high mortality rate. …”
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“…Sepsis induces a wide range of effects on the red blood cell (RBC). …”
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“…More rigorous investigations to clarify any causal relationship between obesity and mortality in sepsis are needed.…”
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“…This finding adds to the recent advances in immunometabolism that shed light on the importance of metabolism and metabolic intermediates in the regulation of innate immune and inflammatory responses in sepsis. In this article, we summarize recent studies, showing that the activation of immune cells requires aerobic glycolytic metabolism and that lactate produced by aerobic glycolysis may play an immunosuppressive role in sepsis.…”
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“…Decades of sepsis research into a specific immune system-targeting adjunctive therapy have not resulted in the discovery of an effective compound. …”
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“…Although viruses may be important causative agents of culture-negative sepsis worldwide, the incidence, disease burden and mortality of viral-induced sepsis is poorly elucidated. …”
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“…The WISS study showed that mortality was significantly affected by sepsis irrespective of any medical and surgical measures. …”
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“…Sepsis is a leading cause of death in intensive care units, and cardiac dysfunction is an identified serious component of the multi-organ failure associated with this critical condition. …”
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“…To investigate the epidemiology trend and characteristics of sepsis-related hospitalizations in Taiwan, and to compare the differences among different severity levels of sepsis. …”
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“…A growing body of literature, however, suggests that the contact pathway contributes to the pathologic host response to certain infectious organisms that produces the often‐fatal syndrome known as sepsis. The contact pathway factors serve as a central node connecting inflammation to coagulation, and may offer a potentially safe therapeutic target to mitigate the morbidity and mortality associated with sepsis. …”
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“…Sepsis is a deadly inflammatory syndrome caused by an exaggerated immune response to infection. …”
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“…Pediatric sepsis comprises a spectrum of disorders that result from infection by bacteria, viruses, fungi, or parasites. …”
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“…The first use of beta-blockade in sepsis goes back nearly 50 years with successful use in some patients in refractory shock. …”
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“…Sepsis is a dysregulated systemic reaction to a common infection, that can cause life-threatening organ dysfunction. …”
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