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21por Lainšček, Duško, Golob-Urbanc, Anja, Mikolič, Veronika, Pantović-Žalig, Jelica, Malenšek, Špela, Jerala, Roman“…CAR-T cells are highly potent serial killers that may cause serious side effects, so their activity needs to be carefully controlled. …”
Publicado 2023
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22por Davenport, A. J., Cross, R. S., Watson, K. A., Liao, Y., Shi, W., Prince, H. M., Beavis, P. A., Trapani, J. A., Kershaw, M. H., Ritchie, D. S., Darcy, P. K., Neeson, P. J., Jenkins, M. R.“…Chimeric antigen receptor T (CAR-T) cells are effective serial killers with a faster off-rate from dying tumor cells than CAR-T cells binding target cells through their T cell receptor (TCR). …”
Publicado 2018
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23por Fousek, Kristen, Watanabe, Junji, Joseph, Sujith K., George, Ann, An, Xingyue, Byrd, Tiara T., Morris, Jessica S., Luong, Annie, Martínez-Paniagua, Melisa A., Sanber, Khaled, Navai, Shoba A., Gad, Ahmed Z., Salsman, Vita S., Mathew, Pretty R., Kim, Hye Na, Wagner, Dimitrios L., Brunetti, Lorenzo, Jang, Albert, Baker, Matthew L., Varadarajan, Navin, Hegde, Meenakshi, Kim, Yong-Mi, Heisterkamp, Nora, Abdel-Azim, Hisham, Ahmed, Nabil“…At the subcellular level, CD19/20/22CAR T-cells formed dense immune synapses with target cells that mediated effective cytolytic complex formation, were efficient serial killers in single-cell tracking studies, and were as efficacious as CD19CAR T-cells against primary CD19(+) disease. …”
Publicado 2020
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24por Stinchcombe, Jane C., Randzavola, Lyra O., Angus, Karen L., Mantell, Judith M., Verkade, Paul, Griffiths, Gillian M.“…Cytotoxic T lymphocytes (CTLs) are highly effective serial killers capable of destroying virally infected and cancerous targets by polarized release from secretory lysosomes. …”
Publicado 2015
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25por Thakur, Archana, Scholler, John, Kubicka, Ewa, Bliemeister, Edwin T., Schalk, Dana L., June, Carl H., Lum, Lawrence G.“…In summary, metabolically enhanced headless CAR T cells are effective serial killers of tumor targets, secrete cytokines and chemokines, and continue to kill under in vitro hypoxic condition.…”
Publicado 2021
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26por Lum, Lawrence G., Thakur, Archana, Elhakiem, Abdalla, Alameer, Lena, Dinning, Emily, Huang, Manley“…Bispecific antibody (BiAb)-armed activated T cells (BATs) have been developed for targeting and treatment of solid and hematologic malignancies. BATs are serial killers of tumor cells, secrete Th(1) cytokines, and induce adaptive cellular and humoral immune responses in patients (pts). …”
Publicado 2020
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