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  1. 21461
    “…HREM technology permits researchers to take advantage of serial 2D aligned stacks of images to perform 3D reconstructions. …”
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    High Resolution Episcopic Microscopy for Qualitative and Quantitative Data in Phenotyping Altered Embryos and Adult Mice Using the New “Histo3D” System
  2. 21462
    “…This study generated thermostable FMDV mutants (M3 and M10) by serial passages at high temperature, subsequent amplification, and purification. …”
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    A Heat-Induced Mutation on VP1 of Foot-and-Mouth Disease Virus Serotype O Enhanced Capsid Stability and Immunogenicity
  3. 21463
    “…We employed radionuclide-based inflammation-targeted whole-body molecular imaging to identify potential cardio-renal crosstalk after MI in a translational setup. Methods: Serial whole-body positron emission tomography (PET) with the specific CXCR4 ligand (68)Ga-Pentixafor was performed after MI in mice. …”
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    Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction
  4. 21464
    “…. −1.22% [high], p ​= ​0.46) and the proportion of patients experiencing any degree of regression (65.9% vs. 63.5% vs. 63.1%, p ​= ​0.88) was similar across hsCRP strata and when evaluated by levels of achieved LDL-C. There were no serial differences in plaque composition by hsCRP strata. …”
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    C-reactive protein levels and plaque regression with evolocumab: Insights from GLAGOV
  5. 21465
    “…Model 2 included 7-day treatment with ISAVUSULF (prodrug; 74.4, 111.6, or 148.8 mg/kg twice daily), FLU (20 or 100 mg/kg once daily), and no treatment. Serial plasma and tissues samples were obtained for pharmacokinetics (PK) and fungal burden measurement, respectively. …”
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    Efficacy and Associated Drug Exposures of Isavuconazole and Fluconazole in an Experimental Model of Coccidioidomycosis
  6. 21466
    “…ELISA positive pre-pandemic sera were not confirmed in serial tests by AWB, indicating possible ELISA cross-reactivity, probably with other canine coronaviruses. …”
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    SARS-CoV-2 antibodies seroprevalence in dogs from France using ELISA and an automated western blotting assay
  7. 21467
    “…Mepolizumab was administered every 4 weeks for 32 weeks and the levels of various biomarkers were serially analyzed. RESULTS: The serum galectin-10 and ECP significantly and rapidly decreased 4 weeks after initial administration of mepolizumab. …”
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    Mepolizumab decreased the levels of serum galectin-10 and eosinophil cationic protein in asthma
  8. 21468
    “…Consequently, close follow-up with serial brain MRI is performed post-treatment to monitor for recurrent disease. …”
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    TRLS-02. Trial in Progress: A Multicenter Phase 3 Study to Establish the Diagnostic Performance of (18)F-Fluciclovine PET in Detecting Recurrent Brain Metastases after Radiation Therapy (REVELATE)
  9. 21469
    “…Baseline cardiovascular biomarkers (high-sensitivity C-reactive protein, high-sensitivity troponin T, and N-terminal pro-brain natriuretic peptide), as well as serial inflammatory and immune biomarkers, will be evaluated in exploratory analyses. …”
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    Cardiovascular Safety of Degarelix Versus Leuprolide for Advanced Prostate Cancer: The PRONOUNCE Trial Study Design
  10. 21470
    “…METHODS: We conducted a serial, cross-sectional study of National Center for Health Statistics Natality Data representing all live births in the US from 2011 to 2019. …”
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    Trends in prepregnancy cardiovascular health in the United States, 2011–2019
  11. 21471
    “…Moreover, exosomal miR-125b was downregulated after metastasis compared with that at baseline in patients with serial measurements before and after metastasis. CONCLUSIONS: The results imply that exosome-mediated miR-125b exerts anti-metastatic properties in HCC. …”
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    Exosomal miR-125b Exerts Anti-Metastatic Properties and Predicts Early Metastasis of Hepatocellular Carcinoma
  12. 21472
    “…Images of the nasal and temporal corneoscleral limbus were obtained with serial horizontal enhanced depth imaging B-scans and TM width and SC area were measured in each scan. …”
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    Effects of Trabecular Meshwork Width and Schlemm’s Canal Area on Intraocular Pressure Reduction in Glaucoma Patients
  13. 21473
    “…Six different samples were prepared, after serial dilution, culture was performed on MRS culture medium. …”
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    Safety, probiotic properties, antimicrobial activity, and technological performance of Lactobacillus strains isolated from Iranian raw milk cheeses
  14. 21474
    “…Accurate calculation of ADG, however, requires serial measures of body weight over at least 70 days. …”
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    Evaluation of partial body weight for predicting body weight and average daily gain in growing beef cattle
  15. 21475
    “…DESIGN, SETTING, AND PARTICIPANTS: In this qualitative study, serial disease reevaluation discussions that occurred in the clinic, inpatient hospital, or off campus via telephone were recorded among pediatric oncologists, patients with high-risk cancer, and their families across 24 months or until death, whichever occurred first, from 2016 to 2020. …”
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    Facilitators Associated With Building and Sustaining Therapeutic Alliance in Advanced Pediatric Cancer
  16. 21476
    “…SARS-CoV-2 exhibits low viability in human cells in culture. Here, serial passages of a SARS-CoV-2 isolate (original-SARS2) in the human hepatoma cell clone Huh7.5 led to the selection of a variant (adapted-SARS2) with significantly improved infectivity in human liver (Huh7 and Huh7.5) and lung cancer (unmodified Calu-1 and A549) cells. …”
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    Overcoming Culture Restriction for SARS-CoV-2 in Human Cells Facilitates the Screening of Compounds Inhibiting Viral Replication
  17. 21477
    “…Thus, we investigated the potential of 18 kDa translocator protein positron-emission-tomography (TSPO-PET) for assessment of microglial activation in mouse brain before and during chronic immunomodulation. Methods: Serial TSPO-PET was performed during five months of chronic microglia modulation by stimulation of the peroxisome proliferator-activated receptor (PPAR)-γ with pioglitazone in two different mouse models of AD (PS2APP, App(NL-G-F)). …”
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    Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation
  18. 21478
    “…Methods: QRT-PCR analyzed miR-133a expression levels in colorectal cells including HCT116, SW48 cells and human normal colorectal cell line NCM460. A serial biological experiment assessed miR-133a effects on cell proliferation, migration, invasion and apoptosis capacities in HCT116 and SW48 cells. …”
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    FOXD3-induced miR-133a blocks progression and metastasis of colorectal cancer through regulating UBA2
  19. 21479
    “…All the patients underwent conventional MRI and DKI serial, as well as 40 healthy full-term infants (control group). …”
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    Magnetic Resonance Image of Neonatal Acute Bilirubin Encephalopathy: A Diffusion Kurtosis Imaging Study
  20. 21480
    “…The blocks were later washed, vortex mixed, serially diluted, and plated. Ccolony-forming unit/ml was calculated after 3 days of incubation. …”
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    Mechanical and antimicrobial property of different surface treated glass ionomer cements under desiccated condition
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