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  1. 21561
    “…ECGs and PK samples were serially recorded before and post‐dose. In part A, rilzabrutinib 100 mg + ritonavir led to 17‐fold area under the concentration–time curve (AUC(0–∞)) and 7‐fold maximum plasma concentration (C(max)) increases over rilzabrutinib alone. …”
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    A thorough QTc study to evaluate the effects of oral rilzabrutinib administered alone and with ritonavir in healthy subjects
  2. 21562
    “…A subsequent explorative mediation analysis with serial mediators further showed a significant positive association between distress to novelty and maternal overprotective parenting (p < 0.05). …”
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    Behavioral Inhibition in the Second Year of Life Is Predicted by Prenatal Maternal Anxiety, Overprotective Parenting and Infant Temperament in Early Infancy
  3. 21563
    “…METHODS AND RESULTS: We serially assessed the presence of PAVF using pulmonary artery angiography and/or contrast echocardiography during catheterization in 391 consecutive patients who underwent the Fontan procedure and compared the results with the Fontan pathophysiology and all-cause mortality. …”
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    Pulmonary Arteriovenous Fistulae After Fontan Operation: Incidence, Clinical Characteristics, and Impact on All-Cause Mortality
  4. 21564
    “…The minimum inhibitory concentration (MIC) was calculated using a two-fold serial broth dilution method, utilizing a 96-well plate. …”
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    Antimicrobial Effects of (L)-Chg(10)-Teixobactin against Enterococcus faecalis In Vitro
  5. 21565
    “…In particular, the paper describes in detail the robots’ propulsion systems (electric, hydraulic), the structure of the lower limb (serial, parallel, mixed mechanisms), the types and structures of control and sensor systems, and the energy efficiency of the robots. …”
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    Recent Advances in Bipedal Walking Robots: Review of Gait, Drive, Sensors and Control Systems
  6. 21566
    “…IMPORTANCE This article characterizes the interaction between human STING and DENV viral protease complex NS2B3 by constructing serial deletion mutants of STING. Our findings suggest that DENV nonstructural protein NS2B interacts with the transmembrane domains and NS3 with the C-terminal cyclic dinucleotide binding domain of human STING. …”
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    Generation and Characterization of Human-Mouse STING Chimeras That Allow DENV Replication in Mouse Cells
  7. 21567
    “…SII exhibited 77.2% sensitivity and 70.8% specificity at 998.72 CONCLUSION: Serial monitoring of the routinely available biomarkers would provide considerable input regarding inflammatory status and severity progression in COVID-19.…”
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    Influence of laboratory biomarkers on inflammatory indices for assessing severity progression in COVID-19 cases
  8. 21568
    “…In-vitro and intraoperative comparisons were performed. METHODS: Serial dilutions of indocyanine-green (1–2000 μg/mL) were imaged with the 3D, 4 K Olympus Orbeye (system 1) and the 3D, 960 p VisionSense Iridium (system 2). …”
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    Assessment and Comparison of Three Dimensional Exoscopes for Near-Infrared Fluorescence-Guided Surgery Using Second-Window Indocyanine-Green
  9. 21569
    “…In this study, we explored the expression profile of TFB2M in ovarian cancer, its association with infiltration of tumor-associated macrophages (TAMs), and its influence on macrophage polarization. Serial sections of ovarian cancer tissue arrays were stained to detect TFB2M and CD163 expression. …”
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    Mitochondrial transcription factor B2 overexpression increases M2 macrophage infiltration via cytosolic mitochondrial DNA-stimulated Interleukin-6 secretion in ovarian cancer
  10. 21570
    “…Of 132 patients treated with TCZ, 108 had serial measurements of serum complement concentration. …”
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    Hypocomplementemia during tocilizumab treatment: Long-term follow-up results
  11. 21571
    “…METHODS: A cohort study of stable long-term renal transplant recipients was undertaken. Serial circulating monocytic HLA-DR density and other leucocyte populations were quantified by flow cytometry. …”
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    Dampened Inflammatory Signalling and Myeloid-Derived Suppressor-Like Cell Accumulation Reduces Circulating Monocytic HLA-DR Density and May Associate With Malignancy Risk in Long-Term Renal Transplant Recipients
  12. 21572
    “…To do this, GnRH‐green fluorescent protein (GFP) female mice received either DHT or blank capsules for 90 days from postnatal day 21 (n = 6 or 7 per group). Serial tail‐tip blood sampling was used to measure LH dynamics and perfusion‐fixed brains were collected and immunolabelled for vesicular GABA transporter (VGAT) to assess putative GABAergic terminals associated with GFP‐labelled GnRH neurons. …”
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    Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons
  13. 21573
    “…By characterizing the acquisition methods available on an ion mobility (IM)‐enabled orthogonal acceleration time‐of‐flight (oa‐ToF) instrument, the optimum modes for analyte semi‐quantitation can be deduced. METHODS: Serial dilutions of commercial metabolite, peptide, or cross‐linked peptide analytes were prepared in matrices of human urine or Escherichia coli digest. …”
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    Evaluation of acquisition modes for semi‐quantitative analysis by targeted and untargeted mass spectrometry
  14. 21574
    “…CONCLUSIONS: Hemodynamic changes in women who eventually develop hypertensive complications are substantially different. Serial monitoring and plotting against developed normograms can identify women at risk and may allow timely intervention. …”
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    Cardiac output and peripheral vascular resistance during normotensive and hypertensive pregnancy – a systematic review and meta‐analysis
  15. 21575
    “…We assessed the correlation between baseline patient demographic and disease characteristics and baseline 3‐second Paced Auditory Serial Addition Test (PASAT‐3) scores (Spearman's rank test) and the changes from baseline in PASAT‐3 (mixed model repeated measures model) in the fingolimod and placebo (up to 24 months) or placebo‐fingolimod switched (from Month 24 up to 120 months) groups. …”
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    Baseline characteristics and effects of fingolimod on cognitive performance in patients with relapsing‐remitting multiple sclerosis
  16. 21576
    “…Limit of detection, limit of quantitation and linearity were determined by testing serial dilutions of normal plasma. Sample carryover was assessed by testing samples with high and low normal levels of the analytes concerned. …”
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    A performance evaluation of chemiluminescence enzyme immunoassays on the Sysmex CN‐6500 haemostasis analyser
  17. 21577
    “…Healthy participants (N = 27) received single doses of atorvastatin (40 mg) and of a pravastatin (40 mg)/rosuvastatin (10 mg) cocktail—alone or with filgotinib (200 mg once daily for 11 days)—on 2 different occasions with washout in between. Serial pharmacokinetic blood samples were collected, and safety was assessed. …”
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    Assessment of the Effect of Filgotinib on the Pharmacokinetics of Atorvastatin, Pravastatin, and Rosuvastatin in Healthy Adult Participants
  18. 21578
    “…METHODS: Five cohorts of healthy subjects (n = 8 each, randomized 6:2 soticlestat:placebo) received oral soticlestat 100‐600 mg once daily (QD) or 300 mg twice daily (BID) for 10‐14 days. Serial blood and urine samples were obtained on days 1, 7 (blood only) and 14. …”
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    Pharmacokinetics, pharmacodynamics and safety assessment of multiple doses of soticlestat in healthy volunteers
  19. 21579
    “…METHODS: Seven rats were anesthetized and underwent serial MRI scans with hyperpolarized [1–(13)C]pyruvate and perfusion weighted imaging. …”
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    Assessing the effect of anesthetic gas mixtures on hyperpolarized (13) C pyruvate metabolism in the rat brain
  20. 21580
    “…To estimate neuronal density, serial sections were prepared on a cryotome for the above-mentioned brain structures with the subsequent immunohistochemical labeling and confocal microscopy; the neuronal marker (anti-NeuN) was used as the primary antibody. …”
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    Neuronal density in the brain cortex and hippocampus in Clsnt2-KO mouse strain modeling autistic spectrum disorder
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