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23761por Richter, Suzanne, Bedard, Philippe L., Chen, Eric Xueyu, Clarke, Blaise A., Tran, Ben, Hotte, Sebastien J., Stathis, Anastasios, Hirte, Hal W., Razak, Albiruni R. A., Reedijk, Michael, Chen, Zhuo, Cohen, Brenda, Zhang, Wen-Jiang, Wang, Lisa, Ivy, S. Percy, Moore, Malcolm J., Oza, Amit M., Siu, Lillian L., McWhirter, Elaine“…Dose limiting toxicities (DLTs) were assessed by CTCAE v4. Serial plasma was collected for RO (total and unbound) and gemcitabine pharmacokinetic analysis. …”
Publicado 2013
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23762por Hollingshead, Melinda G, Stockwin, Luke H, Alcoser, Sergio Y, Newton, Dianne L, Orsburn, Benjamin C, Bonomi, Carrie A, Borgel, Suzanne D, Divelbiss, Raymond, Dougherty, Kelly M, Hager, Elizabeth J, Holbeck, Susan L, Kaur, Gurmeet, Kimmel, David J, Kunkel, Mark W, Millione, Angelena, Mullendore, Michael E, Stotler, Howard, Collins, Jerry“…Noteworthy observations included a significant decline in HCT-15 colon xenograft ABCB1 transporter expression and increased expression of the kinase KIT in A549 with serial passage. These trends predict sensitivity to agents such as paclitaxel (ABCB1 substrate) and imatinib (c-KIT inhibitor) would be altered with extended passage. …”
Publicado 2014
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23763por Huang, Bingqing, Qian, Juying, Ma, Jianying, Huang, Zheyong, Shen, Yunli, Chen, Xueying, Sun, Aijun, Ge, Junbo, Chen, Haozhu“…Cardiac performance was then quantified by echocardiography as well as molecular and pathologic analysis of heart samples in the peri-infarcted region and the infarcted region at serial time points. The survival and engraftment of transplanted MSCs were also assessed. …”
Publicado 2014
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23764por de Rosa, Francesco, Ridolfi, Laura, Ridolfi, Ruggero, Gentili, Giorgia, Valmorri, Linda, Nanni, Oriana, Petrini, Massimiliano, Fiammenghi, Laura, Granato, Anna Maria, Ancarani, Valentina, Pancisi, Elena, Soldati, Valentina, Cassan, Serena, Riccobon, Angela, Parisi, Elisabetta, Romeo, Antonino, Turci, Livia, Guidoboni, Massimo“…Daily 3 MU IL-2 will be administered subcutaneously for 5 days starting from the second day after each vaccine dose. Serial DTH testing and blood sampling to evaluate treatment-induced immune response will be performed. …”
Publicado 2014
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23765por Levin, Adeera, Perry, Taylor, De Zoysa, Prathibha, Sigrist, Mhairi K, Humphries, Karin, Tang, Mila, Djurdjev, Ognjenka“…Other measurements include BP, kidney function and serial blood levels of biomarkers. The primary analysis will compare any vitamin D therapy versus placebo for the primary outcome defined as the change of PWV from baseline to 6 months. …”
Publicado 2014
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23766por Zhu, Yi, Zhang, Jing-Jing, Xie, Kun-Ling, Tang, Jie, Liang, Wen-Biao, Zhu, Rong, Zhu, Yan, Wang, Bin, Tao, Jin-Qiu, Zhi, Xiao-Fei, Li, Zheng, Gao, Wen-Tao, Jiang, Kui-Rong, Miao, Yi, Xu, Ze-Kuan“…The effects of MUC4/Y were observed by serial in vitro and in vivo experiments based on stable over-expressed cell model. …”
Publicado 2014
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23767por Foley, Jessica M, Scholten II, Donald J, Monks, Noel R, Cherba, David, Monsma, David J, Davidson, Paula, Dylewski, Dawna, Dykema, Karl, Winn, Mary E, Steensma, Matthew R“…Growth rate was assessed using cell doubling times and chemoresistance was assessed by determining cell viability in response to a serial dilution of either doxorubicin or cisplatin. …”
Publicado 2015
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23768por Lucey, Brendan P., Gonzales, Celedon, Das, Ujjwas, Li, Jinhe, Siemers, Eric R., Slemmon, J. Randall, Bateman, Randall J., Huang, Yafei, Fox, Gerard B., Claassen, Jurgen A.H.R., Slats, Diane, Verbeek, Marcel M., Tong, Gary, Soares, Holly, Savage, Mary J., Kennedy, Matthew, Forman, Mark, Sjögren, Magnus, Margolin, Richard, Chen, Xia, Farlow, Martin R., Dean, Robert A., Waring, Jeffrey F.“…Recent studies found that cerebrospinal fluid (CSF) Aβ fluctuates over time, including as a diurnal pattern, and increases in absolute concentration with serial collection. It is currently unknown what effect differences in CSF collection methodology have on Aβ variability. …”
Publicado 2015
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23769por Vajravelu, Mary Ellen, Tobolski, Jared, Burrows, Evanette, Chilutti, Marianne, Xiao, Rui, Bamba, Vaneeta, Willi, Steven, Palladino, Andrew, Burnham, Jon M., McCormack, Shana E.“…All subjects received 1mcg/kg corticorelin per institutional protocol. Serial, timed ACTH and cortisol measurements were obtained. …”
Publicado 2015
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23770por Seidensaal, Katharina, Nollert, Andre, Feige, Agnes Hiou, Muller, Marie, Fleming, Thomas, Gunkel, Nikolas, Zaoui, Karim, Grabe, Niels, Weichert, Wilko, Weber, Klaus-Josef, Plinkert, Peter, Simon, Christian, Hess, Jochen“…Moreover, low ALDH1A2 expression was associated with an unfavorable prognosis of OPSCC patients, however the causal link between reduced ALDH1A2 function and treatment failure has not been addressed so far. METHODS: Serial sections from tissue microarrays of patients with primary OPSCC (n = 101) were stained by immunohistochemistry for key regulators of retinoic acid (RA) signaling, including ALDH1A2. …”
Publicado 2015
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23771por Lu, Hongying, Zhao, Xiao, Wang, Yongze, Ding, Xiaoren, Wang, Jinhua, Garza, Erin, Manow, Ryan, Iverson, Andrew, Zhou, Shengde“…The derived strain, JH14, was metabolically evolved through serial transfers in screw-cap tubes containing glucose. …”
Publicado 2016
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23772por Leon-Acuña, A., Alcala-Diaz, J. F., Delgado-Lista, J., Torres-Peña, J. D., Lopez-Moreno, J., Camargo, A., Garcia-Rios, A., Marin, C., Gomez-Delgado, F., Caballero, J., Van-Ommen, B., Malagon, M. M., Perez-Martinez, P., Lopez-Miranda, J.“…METHODS: 1002 patients were submitted to an oral fat load test meal (OFTT) with 0.7 g fat/kg body weight [12 % saturated fatty acids (SFA), 10 % polyunsaturated fatty acids (PUFA), 43 % monounsaturated fatty acids (MUFA), 10 % protein and 25 % carbohydrates]. Serial blood test analyzing lipid fractions were drawn at 0, 1, 2, 3 and 4 h during postprandial state. …”
Publicado 2016
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23773por Jani, Meghna, Chinoy, Hector, Warren, Richard B., Griffiths, Christopher E. M., Plant, Darren, Fu, Bo, Morgan, Ann W., Wilson, Anthony G., Isaacs, John D., Hyrich, KimmeL., Barton, Anne, Prouse, P. J., Moitra, R. K., Shawe, D. J., Nisar, M., Fairburn, K., Nixon, J., Barnes, T., Hui, M., Coady, D., Wright, D., Morley, C., Raftery, G., Bracewell, C., Bridges, M., Armstrong, D., Chuck, A. J., Hailwood, S., Kumar, N., Ashok, D., Reece, R., O'Reilly, S. C., Ding, T., Badcock, L. J., Deighton, C. M., Raj, N., Regan, M. R., Summers, G. D., Williams, R. A., Lambert, J. R., Stevens, R., Wilkinson, C., Kelly, C. A., Hamilton, J., Heycock, C. R., Saravanan, V., Cope, A., Garrood, T., Ng, N., Kirkham, B., Green, M., Gough, A., Lawson, C., Das, D., Borbas, E., Wazir, T., Emery, P., Bingham, S., Bird, H. A., Conaghan, P.G., Pease, C. T., Wakefield, R. J., Buch, M., Bruce, I., Gorodkin, R., Ho, P., Parker, B., Smith, W., Jenkins, E., Mukhtyar, C., Gaffney, K., Macgregor, A. J., Marshall, T., Merry, P., DeSilva, C., Birrell, F. N., Crook, P. R., Szebenyi, B., Bates, D., James, D., Gillott, T., Alvi, A., Grey, C., Browning, J., McHale, J. F., Gaywood, I.C., Jones, A. C., Lanyon, P., Pande, I., Doherty, M., Gupta, A., Courtney, P. A., Srikanth, A., Abhishek, A., Das, L., Pattrick, M., Snowden, H. N., Bowden, A. P., Smith, E. E., Klimiuk, P., Speden, D. J., Naz, S., Ledingham, J. M., Hull, R. G., McCrae, F., Cooper, A., Young‐Min, S. A., Wong, E., Shaban, R., Woolf, A. D., Davis, M., Hutchinson, D., Endean, A., Mewar, D., Tunn, E. J., Nelson, K., Kennedy, T. D., Dubois, C., Pauling, J., Korendowych, E., Jenkinson, T., Sengupta, R., Bhalla, A., McHugh, N., O'Neil, T., Herrick, A. L., Jones, A. K., Cooper, R. G., Dixon, W. G., Harrison, B., Buckley, C. D., Carruthers, D. C., Elamanchi, R., Gordon, P. C., Grindulis, K. A., Khattak, F., Raza, K., Situnayake, K., Akil, M., Till, S., Dunkley, L., Tattersall, R., Kilding, R., Tait, T., Maxwell, J., Till, S., Kuet, K.-P., Plant, M. J., Clarke, F., Fordham, J. N., Tuck, S., Pathare, S. K., Paul, A., Marguerie, C. P., Rigby, S. P., Dunn, N., Abbas, I., Filer, C., Abernethy, V. E., Clewes, A. R., Dawson, J. K., Kitas, G., Erb, N., Klocke, R., Whallett, A. J., Douglas, K., Pace, A., Sandhu, R., John, H., Shand, L., Lane, S., Foster, H., Griffiths, B., Griffiths, I., Kay, L., Ng, W.-F., Platt, P. N., Walker, D. J., Peterson, P., Lorenzi, A., Friswell, M., Thompson, B., Lee, M., Pratt, A., Hopkinson, N. D., Dunne, C. A., Quilty, B., Marks, J., Mukherjee, S., Mulherin, D., Chalam, S. V., Price, T., Sheeran, T., Venkatachalam, S., Baskar, S., Al- Allaf, W., McKenna, F., Shah, P., Filer, A., Bowman, S. J., Jobanputra, P., Rankin, E. C., Allen, M., Chaudhuri, K., Dubey, S., Price‐Forbes, A., Ravindran, J., Samanta, A., Sheldon, P., Hassan, W., Francis, J., Kinder, A., Neame, R., Moorthy, A., Bukhari, M., Ottewell, L., Palkonyai, E., Hider, S., Hassell, A., Menon, A., Dowson, C., Kamath, S., Packham, J., Dutta, S., Price, S., Roddy, E., Paskins, Z., O'Reilly, D. T., Rajagopal, V., Bhagat, S., Chattopadhyay, C. B., Green, M., Quinn, D., Isdale, A., Brown, A., Saleem, B., Foo, B., Al Saffar, Z., Koduri, G.“…Antidrug antibody levels were measured by radioimmunoassay, and drug levels were measured by enzyme‐linked immunosorbent assay in 835 serial serum samples obtained 3, 6, and 12 months after initiation of therapy. …”
Publicado 2015
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23774por Trung, Ngo Tat, Hien, Tran Thi Thu, Huyen, Tran Thi Thanh, Quyen, Dao Thanh, Van Son, Trinh, Hoan, Phan Quoc, Phuong, Nguyen Thi Kim, Lien, Tran Thi, Binh, Mai Thanh, Van Tong, Hoang, Meyer, Christian G., Velavan, Thirumalaisamy P., Song, Le Huu“…The presence of abundant human DNA may hamper the sensitivity of PCR in the detection of bacteria. METHODS: We used serial dilutions of E. Coli spiked pseudo-blood-sepsis samples to develop a simple method that combines the use of a polar detergent solvent and adjustment of the basic pH to remove human DNA. …”
Publicado 2016
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23775por Esparza-López, José, Ramos-Elías, Pier A., Castro-Sánchez, Andrea, Rocha-Zavaleta, Leticia, Escobar-Arriaga, Elizabeth, Zentella-Dehesa, Alejandro, León-Rodríguez, Eucario, Medina-Franco, Heriberto, Ibarra-Sánchez, María de Jesus“…Several subpopulations were isolated from the MBCDF (M serial-breast cancer ductal F line) primary breast cancer cells and were successfully maintained in culture and divided in two groups according to their morphology and RTKs expression pattern, and correlated with biological processes like proliferation, migration, anchorage-independent cell growth, and resistance to cytotoxic chemotherapy drugs and tyrosine kinase inhibitors (TKIs). …”
Publicado 2016
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23776por Rankine-Mullings, Angela E, Little, Courtney R, Reid, Marvin E, Soares, Deanne P, Taylor-Bryan, Carolyn, Knight-Madden, Jennifer M, Stuber, Susan E, Badaloo, Asha V, Aldred, Karen, Wisdom-Phipps, Margaret E, Latham, Teresa, Ware, Russell E“…Secondary objectives include the effects of hydroxyurea on serial TCD velocities, the incidence of neurological and non-neurological events, quality of life (QOL), body composition and metabolism, toxicity and treatment response, changes to brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA), genetic and serologic markers of disease severity, and cognitive and pulmonary function. …”
Publicado 2016
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23777por Oehlke, Oliver, Mix, Michael, Graf, Erika, Schimek-Jasch, Tanja, Nestle, Ursula, Götz, Irina, Schneider-Fuchs, Sabine, Weyerbrock, Astrid, Mader, Irina, Baumert, Brigitta G., Short, Susan C., Meyer, Philipp T., Weber, Wolfgang A., Grosu, Anca-Ligia“…The primary endpoint (PFS) is determined by serial MRI scans, supplemented by AA-PET-scans and/or biopsy/surgery if suspicious of progression. …”
Publicado 2016
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23778por Stammes, Marieke A., Maeda, Azusa, Bu, Jiachuan, Scollard, Deborah A., Kulbatski, Iris, Medeiros, Philip J., Sinisi, Riccardo, Dubikovskaya, Elena A., Snoeks, Thomas J. A., van Beek, Ermond R., Chan, Alan B., Löwik, Clemens W. G. M., DaCosta, Ralph S.“…A similar trend was observed using in vivo photoacoustic imaging, which was validated by ex vivo tissue fluorescence and photoacoustic imaging. Serial quantitative radioactivity measurements of probe biodistribution further demonstrated increased probe accumulation in irradiated tumors. …”
Publicado 2016
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23779por Raphael, Claire E., Keegan, Jennifer, Parker, Kim H., Simpson, Robin, Collinson, Julian, Vassiliou, Vass, Wage, Ricardo, Drivas, Peter, Strain, Stephen, Cooper, Robert, de Silva, Ranil, Stables, Rod H., Di Mario, Carlo, Frenneaux, Michael, Pennell, Dudley J., Davies, Justin E., Hughes, Alun D., Firmin, David, Prasad, Sanjay K.“…METHODS: CMR scans were undertaken in a serial cohort of patients who had undergone invasive WIA. …”
Publicado 2016
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23780por Kobayashi, Miwako, Conklin, Laura M., Bigogo, Godfrey, Jagero, Geofrey, Hampton, Lee, Fleming-Dutra, Katherine E., Junghae, Muthoni, Carvalho, Maria da Gloria, Pimenta, Fabiana, Beall, Bernard, Taylor, Thomas, Laserson, Kayla F., Vulule, John, Van Beneden, Chris, Kim, Lindsay, Feikin, Daniel R., Whitney, Cynthia G., Breiman, Robert F.“…In 2011, Kenya became one of the first African countries to introduce the 10-valent pneumococcal conjugate vaccine (PCV10) into its national immunization program. Serial cross-sectional colonization surveys were conducted to assess baseline pneumococcal colonization, antibiotic resistance patterns, and factors associated with resistance. …”
Publicado 2017
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