“…These investigations are a key contribution to technical work within the HPC collaboration among CERN, SKA, GEANT and PRACE.…”
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“…Storage has been identified as the main challenge for the future distributed computing infrastructures: Particle Physics (HL-LHC, DUNE, Belle-II), Astrophysics and Cosmology (SKA, LSST). In particular, the High Luminosity LHC (HL-LHC) will begin operations in the year of 2026 with expected data volumes to increase by at least an order of magnitude as compared with the present systems. …”
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“…We discuss some recent examples from this dynamic field, and show some new data in support of previously published biomarkers for suicidality (SAT1, MARCKS and SKA2). Methodological clarity and rigor in terms of biomarker discovery, validation and testing is needed. …”
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“…Binding partners include the Ska complex, the replication licensing factor Cdt1, the Dam1 complex, TACC-TOG microtubule-associated proteins (MAPs) and kinesin motors. …”
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“…In parallel, BUB-1 limits attachment maturation by the SKA complex. This activity opposes kinetochore-microtubule attachment stabilisation promoted by CLS-2(CLASP)-dependent kinetochore-microtubule assembly. …”
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“…To explore how kinetochores achieve this, we used two- and three-color subpixel fluorescence localization to define how proteins from six major complexes (CCAN, MIS12, NDC80, KNL1, RZZ, and SKA) and the checkpoint proteins Bub1, Mad1, and Mad2 are organized in the human kinetochore. …”
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“…He is working among others on data processing technologies for the SKA.…”
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“…--HTML-->MeerKAT, one of the SKA (Square Kilometer Array) precursor telescopes, was inaugurated on the 13th of July 2018 in South Africa. …”
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“…HuR-deficient NK cells displayed defects in the metaphase of the cell cycle, including decreased expression and alternative splicing of Ska2, a component of the spindle and kinetochore complex. …”
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“…Ultimately, the future SKA Pulsar Timing Arrays could probe the existence of even a single stellar-mass PBH in our Observable Universe.…”
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“…SK secreted by groups A, C, and G Streptococcus (SKA/SKC/SKG) is composed of three domains: SKα, SKβ and SKγ. …”
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“…Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. Conclusions: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.…”
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“…This arrest is not due to an inability to recruit the kinetochore‐microtubule stabilizing SKA complex and cannot be overridden by mutations in the Ndc80 tail that strengthen microtubule attachment. …”
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“…The hybrid HWE-family histidine kinase, SkaH, is central among these regulators and forms heteromeric complexes with the kinases, LovK and SpdS. …”
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“…Coexpression analysis revealed that CDCA2 could be positively related to ASPM, SKA1, DLGAP5, NCAPG, and CDCA8 and was negatively associated with ETNPPL, LDHD, MRVI1, CBX7, and CENPJ. …”
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“…Data Carousel technology may be applicable to other scientific communities, such as SKA, DUNE, Vera Rubin Observatory, BELLE II, and NICA to manage large-scale data volumes between different QoS storage elements. …”
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“…Loss of the kinesin KIF18A or the outer kinetochore protein SKA1 in PLK1-compromised cells resulted in mitotic defects, activation of the spindle assembly checkpoint and nuclear reassembly defects. …”
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“…We show that, within the flat ΛCDM model, the Hubble constant H(0) can be constrained with a ~0.91% uncertainty from 10 such systems probably observed with the square kilometer array (SKA) in <30 years. More importantly, the cosmic curvature can be model independently constrained to a precision of ∼0.076. …”
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“…Bioinformatics analysis showed that these DEGs enriched in oocyte meiosis, fanconi anemia pathway, cell cycle, and microRNAs regulation. TOP2A, SPAG5, SKA1, EXO1, TK1 were confirmed to associated with bladder cancer development. …”
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“…We found that Cip2a increases E2F1 expression, which in turn transcriptional activates miR-301a by occupying the miR-301a host gene SKA2 promoter. Moreover, we found that miR-301a level is significantly increased in TNBC tissues, and up-regulation of miR-301a is responsible for Cip2a-induced cell proliferation and invasion of TNBC cells. …”
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