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  1. 21
    “…We further find that Ska is progressively loaded onto bioriented kinetochore pairs as they congress. …”
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    Congressing kinetochores progressively load Ska complexes to prevent force-dependent detachment
  2. 22
    “…BACKGROUND: Spindle and Kinetochore Associated Complex Subunit 3 (SKA3) is a part of the SKA complex, which plays a key role in cell mitosis. …”
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    SKA3 overexpression predicts poor outcomes in skin cutaneous melanoma patients
  3. 23
    “…But the relationship between SKA3 and early breast cancer remains unclear. The study aimed to explore the prognostic significance of SKA3 in breast cancer. …”
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    Overexpression of SKA3 correlates with poor prognosis in female early breast cancer
  4. 24
    “…We performed in vitro and in vivo experiments to investigate the role of the circular RNA circSKA3 in tumor development. We examined the effects of circSKA3 on mediating breast cancer metastasis. …”
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    Promotion of tumor progression by exosome transmission of circular RNA circSKA3
  5. 25
    “…BACKGROUND: Spindle and kinetochore‑associated complex subunit 3 (SKA3) has recently been considered a key regulator of carcinogenesis. …”
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    SKA3 is a prognostic biomarker and associated with immune infiltration in bladder cancer
  6. 26
    “…In the present study, we aimed to investigate the role of SKA1 in the process of metastasis and drug resistance of NSCLC. …”
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    SKA1 regulates the metastasis and cisplatin resistance of non-small cell lung cancer
  7. 27
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    PT613. The Role of SKA2 Genetic and Epigenetic Variation in Obsessive-Compulsive Disorder
  8. 28
    “…BACKGROUND: Spindle and kinetochore associated protein 1 (SKA1) is a protein involved in chromosome congression and mitosis. …”
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    SKA1 promotes malignant phenotype and progression of glioma via multiple signaling pathways
  9. 29
    “…Both the Ndc80-tail, which we reveal to be essential for microtubule end-tracking, and Ndc80-bound Ska stabilize microtubule ends in a stalled conformation. …”
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    Molecular determinants of the Ska-Ndc80 interaction and their influence on microtubule tracking and force-coupling
  10. 30
    “…Proline-rich protein 11 (PRR11) together with its upstream adjacent gene, spindle and kinetochore associated 2 (SKA2), represent a classic, head-to-head gene pair. …”
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    PRR11 and SKA2 promote the proliferation, migration and invasion of esophageal carcinoma cells
  11. 31
    “…BACKGROUND: Spindle and kinetochore-associated complex subunits 1–3 (SKA1–3) stabilize the kinetochore-attached spindle microtubules in metaphase. …”
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    SKA1/2/3 is a biomarker of poor prognosis in human hepatocellular carcinoma
  12. 32
    “…The KMN network (named according to the acronym for KNL1, Mis12, and Ndc80) and the more recently identified Ska complex (Ska1–3) have been shown to mediate kinetochore (KT)–microtubule (MT) attachments. …”
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    Aurora B controls kinetochore–microtubule attachments by inhibiting Ska complex–KMN network interaction
  13. 33
    “…Interaction of SKA2 with stress predicted suicidal behavior with ~80% accuracy. …”
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    Epigenetic and genetic variation at SKA2 predict suicidal behavior and post-traumatic stress disorder
  14. 34
    “…Structural studies reveal that EB1 either with Ska1 or Ska complex forms extended structures on microtubule lattice. …”
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    EB1 regulates attachment of Ska1 with microtubules by forming extended structures on the microtubule lattice
  15. 35
    “…Mechanistic investigations revealed that HOTAIR might act as an endogenous ‘sponge’ of miR-141, thereby regulating the derepression of SKA2. Further, we explored the molecular mechanism by which miR-141 expression was regulated, and found that the miR-141 promoter was hypermethylated and that promoter methylation of miR-141 was mediated by DNMT1 in glioma cells. …”
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    Epigenetic modification of miR-141 regulates SKA2 by an endogenous ‘sponge’ HOTAIR in glioma
  16. 36
    “…Knockdown of SKA3 in CRC cells dramatically reduced cell growth rates and increased apoptosis. …”
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    Over-expression of AURKA, SKA3 and DSN1 contributes to colorectal adenoma to carcinoma progression
  17. 37
    “…Our previous study found that two novel cancer-related genes, PRR11 and SKA2, constituted a classic gene pair that was regulated by p53 and NF-Y in lung cancer. …”
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    PRR11 and SKA2 gene pair is overexpressed and regulated by p53 in breast cancer
  18. 38
    “…METHODS: ONCOMINE, GEPIA, UALCAN, TCGA, STRING and other databases were used to analyze the expression of SKA1/2/3 in patients with lung adenocarcinoma (LUAD) and its clinical value, and to explore the possible regulatory mechanism of SKA in the occurrence and development of LUAD. …”
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    SKA1/2/3 serves as a biomarker for poor prognosis in human lung adenocarcinoma
  19. 39
    “…In addition, we used western blotting to quantify the expression levels of relevant proteins in these cells, and we assessed the interaction between SKA3 and polo-like kinase-1 (PLK-1) via co-immunoprecipitation.In this study, we observed elevated SKA3 expression in Bca tissues and cell lines. …”
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    SKA3 Promotes Cell Growth in Breast Cancer by Inhibiting PLK-1 Protein Degradation
  20. 40
    “…Small interfering RNA (siRNA) for SKA3 (si-SKA3) was used to down-regulate SKA3 in A549 cells. pcDNA3.1- SKA3 was used to overexpress SKA3 in A549 cells. …”
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    SKA3 Up-regulation Promotes Lung Adenocarcinoma Growth and is a Predictor of Poor Prognosis
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