“…Pipelines show consistent types of biases, with those incorporating SomaticSniper and Battenberg preferentially predicting homogenous cancer cell populations and those using MuTect tending to predict multiple populations of cancer cells. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To address this issue, SNP analysis was performed using the UCSC hg19 program in 10 acute myeloid leukemia patients (samples, G1 to G10), and somatic mutations were identified in the same tumor sample using SomaticSniper and VarScan2. SNPs in KRAS were detected in 4 out of 10 different individuals, and those of DNMT3A were detected in 5 of the same patient cohort. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Four popular somatic single nucleotide variant (SNV) calling methods (Varscan, SomaticSniper, Strelka and MuTect2) were carefully evaluated on the real whole exome sequencing (WES, depth of ~50X) and ultra-deep targeted sequencing (UDT-Seq, depth of ~370X) data. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also found that PE specificity in human cells could be further improved by incorporating mutations from engineered Cas9 variants, particularly eSpCas9 and Sniper Cas9, into PE.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, HSP90 is also required for the autoimmunity of the Dominant Negative (DN)-SNIPER1 and gain-of-function ADR1-L2 D484V transgenic lines, suggesting a broad role for HSP90 in NLR-mediated defense. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using PROMO3.0, GeneCard and MicroSNiper, 4 EZH2 SNPs with functional relevance in CCA were selected in silico. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Sound source localization is a well-researched subject with applications ranging from localizing sniper fire in urban battlefields to cataloging wildlife in rural areas. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Using the NIST-GIAB gold standard, we compared the performance of five popular somatic SNV calling algorithms (GATK UnifiedGenotyper followed by simple subtraction, MuTect, Strelka, SomaticSniper and VarScan2) for matched tumor-normal amplicon and exome sequencing data. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We found that the critical specificity enhancement step is activated during DNA:RNA heteroduplexation for evoCas9 and HypaCas9, while it occurs in the post-heteroduplexation stage for Cas9-HF1, eCas9, and Sniper-Cas9. This study sheds new light on the conformational dynamics behind the target specificity of Cas9, which will help strengthen its rational designing principles in the future.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Kennedy was assassinated while riding in an open motorcade by a sniper in Dallas, Texas on 22 November 1963. A civilian bystander, Mr. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We have performed a comprehensive evaluation using exome sequencing and targeted deep sequencing data of paired tumor-normal samples from five breast cancer patients to evaluate the performance of nine publicly available somatic variant callers: EBCall, Mutect, Seurat, Shimmer, Indelocator, Somatic Sniper, Strelka, VarScan 2 and Virmid for the detection of single nucleotide mutations and small deletions and insertions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The following databases and bioinformatics tools were used for the analysis: miRBase, miRNA Genomic Viewer, MultAlin, miRNA SNiPer, TargetScan, Ensembl, MethPrimer, TarBase, miRecords, and ChIPBase. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Some of the high-fidelity Cas9 variants have been ranked as Sniper-Cas9, eSpCas9 (1.1), SpCas9-HF1, HypaCas9, xCas9, and evoCas9. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To evaluate inhibitory function in realistic environmental settings, the current study compared stop-signal responses in two different scenarios: one uses simple visual symbols as go and stop signals, and the other translates the typical design into a battlefield scenario (BFS) where a sniper-scope view was the background, a terrorist image was the go signal, a hostage image was the stop signal, and the task instructions were to shoot at terrorists only when hostages were not present but to refrain from shooting if hostages appeared. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Using the updated Version 5.0 of our previously developed bioinformatics tool miRNA SNiPer we assembled polymorphic miRNA genes in chicken. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…When extended gRNAs with one or two non-matching guanines added to the 5′ end were used, Sniper1-Cas9 showed the lowest promiscuity while maintaining high on-target activity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The devices used for flow augmentation were two 2.1 French balloon microcatheters (Sniper™, Embolx). One balloon was inflated distal to target vessel and the second was inflated proximal to protect from reflux. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the battlefield scenario, the signs of fixation, go and stop were replaced by images of a sniper scope, a target and a non-target. The battlefield scenario is a shooting game between the enemy and the soldiers. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…UTR-localized SNPs in the PRKCI gene were evaluated using the PolymiRTS, miRNASNP, and MicroSNIper for association with miRNAs. Furthermore, the SNPs were subjected to analysis using GTEx, RNAfold, and PROMO. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…For somatic variant calling, our algorithm achieves comparable or even better accuracy, at fast speed, than the leading VarScan2, SomaticSniper, JointSNVMix2 and MuTect. CONCLUSIONS: SNVSniffers demonstrates the feasibility to develop integrated solutions to fast and efficient identification of germline and somatic variants. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso