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  1. 361121
    “…At Week 12, the adjusted mean change from baseline in MMD was − 8.2 days for erenumab and − 6.6 days for placebo, with a statistically significant difference for erenumab versus placebo (adjusted mean difference vs placebo: − 1.57 [95%CI: − 2.83, − 0.30]; P = 0.015). …”
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    A phase 3, randomised, placebo-controlled study of erenumab for the prevention of chronic migraine in patients from Asia: the DRAGON study
  2. 361122
    por Manzini, Paola Maria, Ciccone, Giovannino, De Rosa, Francesco Giuseppe, Cavallo, Rossana, Ghisetti, Valeria, D’Antico, Sergio, Galassi, Claudia, Saccona, Fabio, Castiglione, Anna, Birocco, Nadia, Francisci, Tiziana, Hu, Huijing, Pecoraro, Clara, Danielle, Franca, Labanca, Luciana, Bordiga, Anna Maria, Lorenzi, Marco, Camisasca, Giovanni, Giachino, Osvaldo, Pagliarino, Mauro, Ottone, Piero, Scuvera, Ilvana Tiziana Donatella, Guaschino, Roberto, Freilone, Roberto, Berti, Pierluigi, Pittaluga, Fabrizia, Avolio, Maria, Costa, Cristina, Raso, Samuele, Nucci, Aurora, Milan, Massimo, Baffa, Alessandra, Russo, Alessandra, Tornello, Antonella, Maddalena, Laura, Delios, Grazia, Marletto, Fabio Paolo, De Micheli, Anna Grazia, Mattei, Alessio, Baldassano, Stefano, Canta, Francesca, Russo, Maria Luisa, Bergamo, Daniele, Vitale, Francesco, Liccardi, Marco Maria, Chinaglia, Alessandra, Calcagno, Andrea, Converso, Marcella, Aldieri, Chiara, Libanore, Valentina, Blangetti, Ilaria, Benedetti, Valentina, Mitola, Barbara, Scozzari, Gitana
    Publicado 2022
    “…Time to viral clearance from respiratory tract was 21 days for Convalescent, 28 for Standard plasma and 23 in Control arm but differences were not statistically significant. No differences for other secondary endpoints were seen in the three arms. …”
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    Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial
  3. 361123
    “…BACKGROUND: The combination of trifluridine-tipiracil and bevacizumab was compared with trifluridine-tipiracil monotherapy in a randomized, open-label, phase II trial, resulting in a statistically significant and clinically relevant improvement in progression-free survival (PFS), with tolerable toxicity in patients with refractory metastatic colorectal cancer (mCRC); however, evidence supporting the role of this combination in a real-world setting is limited. …”
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    Real-World Activity and Safety of Trifluridine-Tipiracil Plus Bevacizumab Therapy in Patients with Refractory Metastatic Colorectal Cancer
  4. 361124
    “…CONCLUSIONS: We report that reticulocytosis does not have a statistically significant effect on the detection of G6PD deficiency in newborns by both qualitative and quantitative methods.…”
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    Effect of neonatal reticulocytosis on glucose 6-phosphate dehydrogenase (G6PD) activity and G6PD deficiency detection: a cross-sectional study
  5. 361125
    “…CONCLUSION: There was no statistically significant difference in all-cause mortality among the three ICU staffing periods. …”
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    Clinical impact of physician staffing transition in intensive care units: a retrospective observational study
  6. 361126
    “…Compared to healthy controls, lower methylation percentage of FKBP5-12 CpG 1 was observed in adolescents with persistent depressive symptoms after adjusting for covariates (case: 0.94 ± 2.00, control: 0.47 ± 0.92; F = 5.41, P = 0.021), although the statistical significance of the difference was lost after false discovery rate correction (q > 0.05). …”
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    The association of FKBP5 gene methylation, adolescents’ sex, and depressive symptoms among Chinese adolescents: a nested case-control study
  7. 361127
    “…Recruitment was stopped as statistical assumptions were not met. The median age was 52; 21 (58%) patients had triple-negative disease, 28 (78%) visceral involvement, and 27 (75%) ≥ 2 metastatic locations. …”
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    Pembrolizumab in combination with gemcitabine for patients with HER2-negative advanced breast cancer: GEICAM/2015–04 (PANGEA-Breast) study
  8. 361128
    “…RESULTS: The general clinical and imaging features of the groups of patients with simple and complex fractures, namely, sex, age, the lesion site, living or working environment, eccentric growth patterns, Campanacci grading system, and duration of symptoms before treatment, showed varying degrees of differences, but with no statistical significance (p > 0.05). The incidence rate of surrounding soft tissue mass was 35.2% (32/91) in the group with simple fractures, whereas it was 87.2% (34/39) in the group with complex fractures, which showed a significant difference (p < 0.05). …”
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    Mid-term results of giant cell tumours with pathologic fractures around the knee: a multicentre retrospective study
  9. 361129
    “…Enacted sex work stigma and anticipated HIV stigma were not statistically associated with environmental QoL. CONCLUSIONS: This study highlights the need to consider the impact of multiple stigmas on FSW’s non-HIV related clinical outcomes, including safety and physical well-being. …”
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    HIV- and sex work-related stigmas and quality of life of female sex workers living with HIV in South Africa: a cross-sectional study
  10. 361130
    “…CONCLUSIONS: Although the addition of denosumab to csDMARDs did not find statistically significant improvements in bone erosion after 6 months of treatment, numerical improvements in these parameters suggest that the addition of denosumab to csDMARDs may be effective in inhibiting the progression of bone erosion and improving bone micro-architecture. …”
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    Inhibition of bone erosion, determined by high-resolution peripheral quantitative computed tomography (HR-pQCT), in rheumatoid arthritis patients receiving a conventional synthetic disease-modifying anti-rheumatic drug (csDMARD) plus denosumab vs csDMARD therapy alone: an open-label, randomized, parallel-group study
  11. 361131
    “…In intent-to-treat analyses, CHFS scores were 1.2 points lower (95% CI − 2.8 to 0.3) for intervention compared to usual care 3 months post-randomization and 0.1 points lower (95% CI − 1.8 to 1.6 points) 6 months post-randomization. There were no statistically significant differences in other outcomes. …”
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    Randomized controlled trial of an internet-based self-guided hand exercise program to improve hand function in people with systemic sclerosis: the Scleroderma Patient-centered Intervention Network Hand Exercise Program (SPIN-HAND) trial
  12. 361132
    “…The strength of the association was done using adjusted hazard ratio (AHR) with 95% confidence intervals. Statistical significance was declared at p value < 0.05. …”
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    Predictors of time to recovery from uncomplicated severe acute malnutrition among 6–59 months children treated in out patient treatment in health posts of Nagele Arsi district: a retrospective cohort study
  13. 361133
    “…After adjustment, there was no statistically significant difference between the groups regarding post-operative physical exams. …”
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    Comparison of two different types of hybrid Tibial fixations for anterior cruciate ligament reconstruction: a prospective comparative cohort study
  14. 361134
    “…Data were pooled using a random-effects model. All statistical analyses were performed using Stata 17. …”
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    The effectiveness of eHealth interventions on moderate-to-vigorous intensity physical activity among cardiac rehabilitation participants: a systematic review and meta-analysis
  15. 361135
    “…The primary outcome is mental QOL; statistical criteria for superiority is defined as a 4-point difference between groups at post-treatment. …”
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    Finding My Way-Advanced: can a web-based psychosocial intervention improve the mental quality of life for women with metastatic breast cancer vs attention-control? Study protocol of a randomised controlled trial
  16. 361136
    “…Joint activity was weakly associated with RD at baseline at the patient-level (Pearson’s coefficients: range 0.12–0.18), but strongly associated at the individual joint-level, with a higher probability of tender/swollen joints to associate with higher JSN/erosion scores: all 42 analysed joints showed statistical significance at the 0.05 level (unadjusted) for the relationship between joint tenderness (yes/no) and its JSN score, all but one for tenderness and bone erosion scores, and all but 2 for swollen and JSN scores and for swollen and bone erosion score. …”
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    Quantification of pre-existing radiographic damage and its relationship with joint activity and long-term clinical outcomes with secukinumab therapy in patients with psoriatic arthritis
  17. 361137
    “…The mean age of dead patients (71.17 ± 14.44 years) was statistically significant higher than recovered patients (58.25 ± 16.52 years). …”
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    Interpretable generalized neural additive models for mortality prediction of COVID-19 hospitalized patients in Hamadan, Iran
  18. 361138
    “…We adopted disease-free survival (DFS) as the primary outcome for maximum statistical power and recurrence rate and overall survival (OS) as secondary outcomes. …”
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    Survival outcomes of stage I colorectal cancer: development and validation of the ACEPLY model using two prospective cohorts
  19. 361139
    “…All the subjects were in the disaster area and experienced the rainstorm personally, with normal intelligence. The statistical results showed that 25.37% people had experienced at least three rainstorm-related stresses, nearly 20.26% people had post-traumatic stress disorder (PTSD) symptoms, and 39.3%, 53.92% and 65.83% people had depression, anxiety and stress symptoms, respectively. …”
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    Psychological challenges and related factors of ordinary residents after “7.20” heavy rainstorm disaster in Zhengzhou: a cross-sectional survey and study
  20. 361140
    “…Although the five models predicted NDs events, the discriminative ability was superior using TabTransformer (Uno’s C-statistic (coefficient (95% confidence intervals)) 0.757 (0.702, 0.805). …”
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    Machine learning for predicting neurodegenerative diseases in the general older population: a cohort study
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