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  1. 69081
    “…Recently, oral CLA also has been shown to increase testosterone (T) biosynthesis, which is known to diminish traumatic brain injury (TBI)-induced neuropathology and reduce deficits induced by stroke in adult rats. To test the impact of CLA on cognitive recovery following a TBI, 5–6 month old male Sprague Dawley rats received a focal injury (craniectomy + controlled cortical impact (CCI; n = 17)) or Sham injury (craniectomy alone; n = 12) and were injected with 25 mg/kg body weight of Clarinol(®) G-80 (80% CLA in safflower oil; n = 16) or saline (n = 13) every 48 h for 4 weeks. …”
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    Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury
  2. 69082
    “…Lastly, examination of similar traits in a sample of female twins (TwinsUK, n = 2,902), adjusting for age and BMI, allowed independent replication of the findings and exploration of the influence of additive genetic (A) factors and shared (C) and non-shared (E) environmental factors predisposing to co-occurring chronic widespread pain (CWP) and cardiovascular disease (hypertension, angina, stroke, heart attack, elevated cholesterol, angioplasty or bypass surgery). …”
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    Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study
  3. 69083
    “…There were significant reductions in LV end systolic diameter (3.4 ± 0.2 vs. 3.09 ± 0.3 cm, P = 0.002), LV posterior wall thickness (0.99 ± 0.1 vs. 0.9 ± 0.1 cm, P = 0.013), relative wall thickness (0.4 ± 0.06 vs. 0.36 ± 0.05, P = 0.027) estimated filling pressure (E/E' ratio 6.08 ± 1.87 vs. 5.01 ± 0.82, P = 0.006) and proportion of participants with LV concentric remodeling (30.8% vs. 7.8%, P = 0.035), and significant increases in LV ejection fraction (60.8 ± 3 vs. 68.3 ± 4%, P < 0.001), fractional shortening (31.6 ± 4.5 vs. 39.9 ± 5%, P < 0.001), cardiac output (4.3 ± 0.7 vs. 6.1 ± 1L·min(−1), P < 0.001), and stroke volume (74.6 ± 11 vs. 96.3 ± 13.5 ml, P < 0.001). …”
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    Acute cardiac functional and mechanical responses to isometric exercise in prehypertensive males
  4. 69084
    por Ho, Jean K., Nation, Daniel A.
    Publicado 2017
    “…BACKGROUND: Prior work suggests that some but not all antihypertensive treatments may benefit cognition and risk for Alzheimer’s disease, independent of stroke. Angiotensin II receptor blockers (ARBs) have been highlighted as one antihypertensive drug class that may confer greatest benefit. …”
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    Memory is preserved in older adults taking AT1 receptor blockers
  5. 69085
    por Yan, Ruohua, Li, Wei, Yin, Lu, Wang, Yang, Bo, Jian, Liu, Lisheng, Liu, Bing, Hu, Bo, Chen, Chunming, Guo, Jin, Zhang, Hongye, Chen, Hui, Li, Jian, Li, Juan, Yang, Jun, Wang, Kean, Zhang, Li, Deng, Qing, Ren, Bing, Chen, Tao, Xu, Tao, Wang, Wei, Zhao, Wenhua, Chang, Xiaohong, Cheng, Xiaoru, He, Xinye, Hou, Xixin, Wang, Xingyu, Bai, Xiulin, Zhao, Xiuwen, Liu, Xu, Jia, Xuan, Sun, Yi, Zhai, Yi, Li, Dong, Chen, Di, Jin, Hui, Tian, Jiwen, Ma, Yumin, Li, Yindong, He, Chao, You, Kai, Zhang, Songjian, Tian, Xiuzhen, Xu, Xu, Di, Jinling, Wu, Jianquan, Wang, Mei, Zhou, Qiang, Zhang, Shiying, Han, Aiying, Cao, Minzhi, Wu, Jianfang, Jiang, Weiping, Qiang, Deren, Qin, Jing, Qian, Shan, Shi, Suyi, Zhou, Yihong, Qian, Zhenzhen, Liu, Zhengrong, Dong, Changlin, Wan, Ming, Li, Jun, Tang, Jinhua, Mo, Yongzhen, Bian, Rongwen, Lou, Qinglin, Lei, Rensheng, Hu, Lihua, Xiong, Shuwei, Zhong, Yan, Li, Ning, Tang, Xincheng, Ye, Shuli, Liu, Yu, Li, Chunyi, Li, Yujin, Fu, Minfan, Wang, Qiuyuan, Fu, Xiaoli, Xing, Xiaojie, Guo, Baoxia, Feng, Huilian, Xu, Lihui, Yang, Yuqing, Ma, Haibin, Wu, Ruiqi, Wang, Yali, Ma, Xiaolan, Liu, Hongze, Ma, Yurong, Liao, Xiaoyang, Yuan, Bo, Zhao, Qian, Xu, Guofan, He, Hui, Liu, Jiankang, Wang, Xin, Chen, Ming, Deng, Wenqing, Lu, Fanghong, Liu, Zhendong, Zhang, Hua, Sun, Shangwen, Wang, Shujian, Zhao, Yingxin, Diao, Yutao, Shi, Xuezheng, Ren, Debin, Wei, Chuanrui, Zhang, Liangqing, Wang, Jufang, Fan, Lianghou, Liu, Guoqin, Hou, Yan, Wu, Cuiying, Ma, Guilan, Wei, Hua, Wang, Junying, Bao, Xiongfei, Tang, Yue, Liu, Tianlu, Zhi, Yahong, Zhang, Peng, Wang, Ailing, Wang, Huijuan, Liu, Jianna, Liu, Qinzhou, Wang, Rong, Wu, Jianguo, Aili, Aideer, Wula, Ayoufumiti, Bula, Aibi, Yang, Dongmei, Wen, Qian, Xiao, Yize, Shi, Qingping, Shao, Ying, He, Jing, Li, Kehua, Bai, Wuba, Yang, Jinkui, Jiang, Yunchun, Liu, Huaxing, Yang, Shunyun
    Publicado 2017
    “…By contrast, the prevalence of total cardiovascular disease (stroke, ischemic heart disease, and other heart diseases that led to hospitalization) was lower in high‐ and middle‐income regions than in low‐income regions (7.46%, 7.42%, and 8.36%, respectively, P (trend)=0.0064). …”
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    Cardiovascular Diseases and Risk‐Factor Burden in Urban and Rural Communities in High‐, Middle‐, and Low‐Income Regions of China: A Large Community‐Based Epidemiological Study
  6. 69086
    “…Multimorbidity was measured as the simultaneous presence of two or more of the nine chronic conditions including angina pectoris, arthritis, asthma, chronic lung disease, diabetes mellitus, hypertension, stroke, depression, and vision impairment. Multivariable logistic regression models were fitted to test for associations between overweight/obesity and prevalence of non communicable multimorbidity after adjusting for age, sex, rural/urban residence, education, marital status, occupation, household wealth, tobacco smoking, alcohol drinking, fruits and vegetable intake and health insurance status. …”
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    Association Between Body Mass index and Prevalence of Multimorbidity in Low-and Middle-income Countries: A Cross-Sectional Study
  7. 69087
    “…Between 2007 and 2014, JLA partnerships of patients, carers and health professionals agreed on important treatment research questions (priorities) in a range of health conditions, such as Type 1 diabetes, eczema and stroke. We were interested in how much these JLA PSP priorities were similar to treatments undergoing evaluation and research over the same time span. …”
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    Patients’, clinicians’ and the research communities’ priorities for treatment research: there is an important mismatch
  8. 69088
    “…To facilitate interpretation of these data, several ratios have been developed, including pulmonary vascular permeability index (defined as EVLW/(0.25*GEDV)) and global ejection fraction ((4*stroke volume)/GEDV). PVPI and GEF have been associated to the aetiology of pulmonary oedema and systolic cardiac function, respectively. …”
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    Comparison of pulmonary vascular permeability index PVPI and global ejection fraction GEF derived from jugular and femoral indicator injection using the PiCCO-2 device: A prospective observational study
  9. 69089
    “…Fewer plasma plus standard care participants had serious adverse events compared with standard care alone recipients (nine [20%] of 46 vs 20 [38%] of 52, p=0·041), the most frequent of which were acute respiratory distress syndrome (one [2%] vs two [4%] patients) and stroke (one [2%] vs two [4%] patients). INTERPRETATION: Although there was no significant effect of plasma treatment on the primary endpoint, the treatment seemed safe and well tolerated. …”
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    Immune plasma for the treatment of severe influenza: an open-label, multicentre, phase 2 randomised study
  10. 69090
    “…When scaled to 10-mg/dL higher levels of HDL cholesterol, the CETP genetic score was not associated with occlusive CVD (18 550 events; odds ratio [OR], 0.98; 95% CI, 0.91-1.06), major coronary events (5767 events; OR, 1.08; 95% CI, 0.95-1.22), myocardial infarction (3118 events; OR, 1.14; 95% CI, 0.97-1.35), ischemic stroke (13 759 events; OR, 0.94; 95% CI, 0.86-1.02), intracerebral hemorrhage (6532 events; OR, 0.94; 95% CI, 0.83-1.06), or other vascular diseases or carotid plaque. …”
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    Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults
  11. 69091
    “…Rates of all-cause death (HR 0.69, 95% CI 0.27–1.73, P = 0.43) and stroke (HR 0.69, 95% CI 0.10–4.89, P = 0.71) were similar. …”
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    Clinical outcomes of state-of-the-art percutaneous coronary revascularization in patients with de novo three vessel disease: 1-year results of the SYNTAX II study
  12. 69092
    “…The left ventricular ejection fraction, stroke volume, cardiac output, and left ventricular fractional shortening were calculated. …”
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    Tongxinluo Improves Apolipoprotein E-Deficient Mouse Heart Function
  13. 69093
    “…The primary outcome is time to first occurrence of CV death, non-fatal myocardial infarction, or non-fatal stroke. The key secondary outcome is a composite of time to first sustained occurrence of end-stage kidney disease, ≥ 40% decrease in estimated glomerular filtration rate (eGFR) from baseline, or renal death. …”
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    Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA(®)): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk
  14. 69094
    “…The increasing MPO level and MPO/HDL-C, MPO/apoAI ratios can differentiate the SCAD patients at the risk of acute coronary syndrome (ACAD) and stroke.…”
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    Myeloperoxidase level and inflammatory markers and lipid and lipoprotein parameters in stable coronary artery disease
  15. 69095
    “…This trial reported the time to first occurrence of any event from the composite of cardiovascular death, MI and stroke as the primary outcome (hazard ratio 0.84 ticagrelor 60 mg BID vs. placebo, 95% confidence interval 0.74–0.95). …”
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    Ticagrelor for Secondary Prevention of Atherothrombotic Events After Myocardial Infarction: An Evidence Review Group Perspective of a NICE Single Technology Appraisal
  16. 69096
    “…The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, or unstable angina requiring emergency hospitalization. …”
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    High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial
  17. 69097
    Publicado 2018
    “…We used Cox regression models to assess the relevance of diabetes (any type) to occlusive vascular mortality (ischaemic heart disease, ischaemic stroke, or other atherosclerotic deaths) by age, sex, and other major vascular risk factors, and to assess whether the associations of blood pressure, total cholesterol, and body-mass index (BMI) to occlusive vascular mortality are modified by diabetes. …”
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    Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies
  18. 69098
    “…BACKGROUND: Left atrial appendage morphology has been proved to be an important predictor of left atrial thrombus (LAT) and left atrial spontaneous echo contrast (LASEC) and stroke in patients with non-valvular atrial fibrillation (NVAF). …”
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    Predictive value of left atrial appendage lobes on left atrial thrombus or spontaneous echo contrast in patients with non-valvular atrial fibrillation
  19. 69099
    “…We stratified the findings by age, sex, and vascular risk factors, and validated them in trials of aspirin in secondary prevention of stroke. Additionally, we assessed whether any weight or height dependence was evident for the effect of aspirin on 20-year risk of colorectal cancer or any in-trial cancer. …”
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    Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials
  20. 69100
    “…We extracted individual-level data on prevalent cardiometabolic diseases (coronary heart disease, stroke, or diabetes [without differentiation by diabetes type]) at baseline. …”
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    Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study
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