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3381por Kannan, Natarajan, Taylor, Susan S, Zhai, Yufeng, Venter, J. Craig, Manning, Gerard“…This diverse superfamily serves as a model for further structural and functional analysis of enzyme evolution.…”
Publicado 2007
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3382“…Furthermore, the recent structure of an H/ACA complex has revealed the organization of a complete sRNP. …”
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3383“…RESULTS: Using fold recognition, we have identified highly confident computational 3D structural assignments for 21 Mimivirus ORFans. In addition, highly confident functional predictions for 6 of these ORFans were derived by analyzing the conservation of functional motifs between the predicted structures and proteins of known function. …”
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3384por Prendergast, James GD, Campbell, Harry, Gilbert, Nick, Dunlop, Malcolm G, Bickmore, Wendy A, Semple, Colin AM“…The higher-order organisation of chromosomes has often been invoked to explain such phenomena but previously there has been insufficient data on chromosome structure to investigate this rigorously. Using the results of a recent genome-wide analysis of open and closed human chromatin structures we have investigated the global association between divergence, selection and chromatin structure for the first time. …”
Publicado 2007
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3385“…We present here a fine example which points out the interest of MED-SuMo approach for functional structural annotation.…”
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3386“…We propose a model of evolving biological complexity in which environmentally-selected gains or losses of PCI methylation respectively favor positive or negative selection, thus polarizing PCI+ gene structures around a genomic core of ancestral PCI- genes.…”
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3387“…Several classical structure comparison methods are employed; five randomization methods are implemented to generate control sequences; sub-optimal predicted structures can be optionally utilized to mitigate the uncertainty of secondary structure prediction. …”
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3388“…RESULTS: We analysed and compared the structural alignments obtained by different methods using three sets of pairs of structurally related proteins. …”
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3389por Cummings, W. Jason, Yabuki, Munehisa, Ordinario, Ellen C, Bednarski, David W, Quay, Simon, Maizels, Nancy“…Homology-directed repair is a powerful mechanism for maintaining and altering genomic structure. We asked how chromatin structure contributes to the use of homologous sequences as donors for repair using the chicken B cell line DT40 as a model. …”
Publicado 2007
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3390“…BACKGROUND: Many algorithms exist for protein structural alignment, based on internal protein coordinates or on explicit superposition of the structures. …”
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3391
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3392“…In the present work the electronic structures of aflatoxins B(1), G(1), 4-20 dehydro B(1) and of versicolorin A have been determined by the simple Hückel molecular orbital method using a computer, in order to see whether the correlation between electronic structure and biological activity is applicable to these compounds also. …”
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3393
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3394“…Such correlations, involving only bulk molecular properties indicate that the chemical nature of the alkyl substituents need not be the sole determinants of carcinogenic activity. These structure-activity relationships can be used to estimate carcinogenic activity with some degree of confidence.…”
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3395por Prlić, Andreas, Down, Thomas A, Kulesha, Eugene, Finn, Robert D, Kähäri, Andreas, Hubbard, Tim JP“…These provide new commands to share alignments, three dimensional molecular structure data, add the possibility for registration and discovery of DAS servers, and provide a convention how to provide different types of data plots. …”
Publicado 2007
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3396
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3397
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3398por Algaba, F., Mikuz, G., Boccon-Gibod, L., Trias, I., Arce, Y., Montironi, R., Egevad, L., Scarpelli, M., Lopez-Beltran, A.“…The purpose of this paper is to present an overview of the pseudoneoplasic entities arising in the testis and paratesticular structures; emphasis is placed on how the practicing pathologist may distinguish benign mimickers and pseudotumors from true neoplasia. …”
Publicado 2007
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3399“…These include circular permuted protein structures, and the more general cases of non-cyclic permutations between similar structures, which are related by non-topological rearrangement beyond circular permutation. …”
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3400por Nakamura, Fumihiko, Osborn, Teresia M., Hartemink, Christopher A., Hartwig, John H., Stossel, Thomas P.“…We generated a library of FLNa fragments to examine their F-actin binding to define the structural properties of FLNa that enable its various functions. …”
Publicado 2007
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