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1121por Alnami, Barak, Kragskow, Jon G. C., Staab, Jakob K., Skelton, Jonathan M., Chilton, Nicholas F.“…However, this study, like many others, was predicated on an idealized C(3)-symmetric structural model, which may not be representative of the dynamic structure in solution at the single-molecule level. …”
Publicado 2023
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1122“…A symmetry mode analysis yields 47 symmetrically distinct patterns of octahedral tilting in hybrid organic–inorganic layered perovskites that adopt the n = 1 Ruddlesden–Popper (RP) structure. The crystal structures of compounds belonging to this family are compared with the predictions of the symmetry analysis. …”
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1123“…The bias in protein structure and function space resulting from experimental limitations and targeting of particular functional classes of proteins by structural biologists has long been recognized, but never continuously quantified. …”
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1124“…These distinctive secondary structure patterns can be used to represent a protein for visual inspection and in vector-based protein structure comparison. …”
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1125“…BACKGROUND: The structure of proteins may change as a result of the inherent flexibility of some protein regions. …”
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1126por Peters, Brandon, Moad, Charles, Youn, Eunseog, Buffington, Kris, Heiland, Randy, Mooney, Sean“…BACKGROUND: Understanding protein function from its structure is a challenging problem. Sequence based approaches for finding homology have broad use for annotation of both structure and function. 3D structural information of protein domains and their interactions provide a complementary view to structure function relationships to sequence information. …”
Publicado 2006
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1127“…Protein tertiary structure plays an essential role in deciphering protein functions, especially protein structural properties, including domains, active sites and post-translational modifications. …”
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1128“…A comparison of the structure-induction (involving rat and mouse Ah receptor binding) and structure-toxicity (in vivo guinea pig toxicity) relationships suggests that two receptors with structurally distinct binding properties may be involved. …”
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1129“…BACKGROUND: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. …”
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1130“…BACKGROUND: Structural genomics initiatives were established with the aim of solving protein structures on a large-scale. …”
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1131“…Our motif discovery method employs structural alphabet encoding to convert 3D structures to the corresponding 1D structural letter sequences, where the Mg(2+)-structural motifs are identified as recurring structural patterns. …”
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1132“…QSCOP is a quantitative structural classification of proteins which distinguishes itself from other classifications by two essential properties: (i) QSCOP is concurrent with the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Data Bank and (ii) QSCOP covers the widely used SCOP classification with layers of quantitative structural information. …”
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1133Primary structure of diphtheria toxin fragment B: structural similarities with lipid-binding domainsPublicado 1980“…In contrast, the hydrophilic C-terminal 8,000-dalton region of fragment B (PI = 53.8%) does not show structural similarity with lipid- associating domains.…”
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1134Publicado 1985“…To provide information useful for the design of a pilus vaccine effective for the prevention of both meningococcal and gonococcal disease, the electron microscopic morphology of meningococcal pili and the structural and antigenic relationships of meningococcal pili to gonococcal pili were investigated. …”
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1135“…RESULTS: Phylogenies were reconstructed from protein 3D structural data. The phylogenetic trees were used to infer ancestral structures with a consensus method. …”
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1136por Ward, R. Matthew, Erdin, Serkan, Tran, Tuan A., Kristensen, David M., Lisewski, Andreas Martin, Lichtarge, Olivier“…Because the number of protein structures with unknown function is mushrooming, however, we asked here whether such comparisons could be improved by focusing narrowly on the key functional features of protein structures, as defined by the Evolutionary Trace (ET). …”
Publicado 2008
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1137“…SARSA is a web tool that can be used to align two or more RNA tertiary structures. The basic idea behind SARSA is that we use the vector quantization approach to derive a structural alphabet (SA) of 23 nucleotide conformations, via which we transform RNA 3D structures into 1D sequences of SA letters and then utilize classical sequence alignment methods to compare these 1D SA-encoded sequences and determine their structural similarities. …”
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1138por Hvidsten, Torgeir R., Lægreid, Astrid, Kryshtafovych, Andriy, Andersson, Gunnar, Fidelis, Krzysztof, Komorowski, Jan“…BACKGROUND: Sequence similarity to characterized proteins provides testable functional hypotheses for less than 50% of the proteins identified by genome sequencing projects. With structural genomics it is believed that structural similarities may give functional hypotheses for many of the remaining proteins. …”
Publicado 2009
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1140por Soisson, Stephen M, Patel, Sangita B, Abeywickrema, Pravien D, Byrne, Noel J, Diehl, Ronald E, Hall, Dawn L, Ford, Rachael E, Reid, John C, Rickert, Keith W, Shipman, Jennifer M, Sharma, Sujata, Lumb, Kevin J“…BACKGROUND: The unique S28 family of proteases is comprised of the carboxypeptidase PRCP and the aminopeptidase DPP7. The structural basis of the different substrate specificities of the two enzymes is not understood nor has the structure of the S28 fold been described. …”
Publicado 2010
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