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1930por Spek, Anthony L.“…Automated structure validation was introduced in chemical crystallography about 12 years ago as a tool to assist practitioners with the exponential growth in crystal structure analyses. …”
Publicado 2009
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1931“…This approach has been applied to address two questions: whether structures from structural genomics efforts reach the same level of quality as structures from traditional sources and whether the impact factor of the journal in which a structure is published correlates with structure quality. …”
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1932por Xiao, Chuan, Kuznetsov, Yurii G, Sun, Siyang, Hafenstein, Susan L, Kostyuchenko, Victor A, Chipman, Paul R, Suzan-Monti, Marie, Raoult, Didier, McPherson, Alexander, Rossmann, Michael G“…Mimivirus is the largest known virus whose genome and physical size are comparable to some small bacteria, blurring the boundary between a virus and a cell. Structural studies of Mimivirus have been difficult because of its size and long surface fibers. …”
Publicado 2009
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1933por Markley, John L., Aceti, David J., Bingman, Craig A., Fox, Brian G., Frederick, Ronnie O., Makino, Shin-ichi, Nichols, Karl W., Phillips, George N., Primm, John G., Sahu, Sarata C., Vojtik, Frank C., Volkman, Brian F., Wrobel, Russell L., Zolnai, Zsolt“…The Center for Eukaryotic Structural Genomics (CESG) is a “specialized” or “technology development” center supported by the Protein Structure Initiative (PSI). …”
Publicado 2009
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1934“…For each small sequence segment, there are only a few more likely substructures. We call them the ‘structural alphabet’ for this segment. Classical approaches such as ROSETTA used sequence profile and secondary structure information, to predict structural fragments. …”
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1935“…Even though nearly every human gene has at least one alternative splice form, very little is so far known about the structure and function of resulting protein products. …”
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1936
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1937por Ertl, Peter“…The review covers a history of web-based structure input, starting with simple text entry boxes and early molecule editors based on clickable maps, before moving to the current situation dominated by Java applets. …”
Publicado 2010
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1938“…At the centre of every evolutionary process is a population of reproducing individuals. The structure of that population affects evolutionary dynamics. …”
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1939por ten Broeke-Smits, Nicole J. P., Pronk, Tessa E., Jongerius, Ilse, Bruning, Oskar, Wittink, Floyd R., Breit, Timo M., van Strijp, Jos A. G., Fluit, Ad C., Boel, C. H. Edwin“…Knowledge of operon structures is crucial to fully understand the pathophysiology of infections. …”
Publicado 2010
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1940por Do, Thuy, Jolley, Keith A., Maiden, Martin C. J., Gilbert, Steven C., Clark, Douglas, Wade, William G., Beighton, David“…A multilocus sequence typing (MLST) scheme for S. oralis was developed and the resultant data analysed to examine the population structure of the species. Analysis of 113 isolates, confirmed as belonging to the S. oralis/mitis group by 16S rRNA gene sequencing, characterized the population as highly diverse and undergoing inter- and intra-species recombination with a probable clonal complex structure. …”
Publicado 2009
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