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  1. 383681
    “…Thus, we utilized Aβ(1–42) as a test subject to perform our study. The production of monomer Aβ(1–42) and their high-molecular oligomer accumulations in neural cells were detected by immunofluorescence assay, ELISA, or Western blot assay. …”
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    Effects and mechanism of Aβ(1−42) on EV-A71 replication
  2. 383682
    “…Furthermore, pTau was compared between negative and positive subject groups for each individual criterion of frailty. …”
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    Potential association between frailty and pTau in community-dwelling older adults
  3. 383683
    “…In particular, there is enormous heterogeneity in cognitive, behavioural and developmental impairments that is complex and can change naturally over time; there is a lack of standardised instruments for evaluating these outcomes in developmental and epileptic encephalopathies, with a reliance on subjective evaluations by proxy (caregivers); and treatment regimes are complex involving multiple ASMs as well as other drugs. …”
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    Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies
  4. 383684
    “…The ICU cohort included 447 subjects, of which 25% (n = 110) were treated pre-4-OLE switch and 75% (n = 337) were post-switch. …”
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    Hospital change to mixed lipid emulsion from soybean oil-based lipid emulsion for parenteral nutrition in hospitalized and critically ill adults improves outcomes: a pre–post-comparative study
  5. 383685
    “…SE-associated subtype-specific upregulated tumor-dependent genes, which were revealed as members of SE-driven core transcriptional regulatory network of G3-MB, were then subjected to functional validation and mechanistic investigation. …”
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    Dissecting super-enhancer driven transcriptional dependencies reveals novel therapeutic strategies and targets for group 3 subtype medulloblastoma
  6. 383686
    “…However, our findings must be interpreted carefully due to declared limitations, e.g., the self-reported assessments which are subject to sources of error and bias or that the dataset used to gauge meeting a guidelines (1994–1996) was made later (2016). …”
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    Trajectories of 24-h movement guidelines from middle adolescence to adulthood on depression and suicidal ideation: a 22-year follow-up study
  7. 383687
    “…The effectiveness against COVID-19 infection of fully vaccinated subjects during the alpha and delta period was respectively 88.20% (CI95% 87.60–99.78) and 59.31% (CI95% 57.91–60.67), against hospitalisation 93.89% (CI95% 92.67–94.90) and 88.32% (CI95% 86.50–89.90) and against death 93.83% (CI95% 91.65–95.45) and 85.91 (CI95% 79.98–90.09). …”
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    Covid-19 vaccination programme effectiveness against SARS-CoV-2 related infections, hospital admissions and deaths in the Apulia region of Italy: a one-year retrospective cohort study
  8. 383688
    “…Our work differs from antecedent studies exploring the same subject in the combination of octapeptide descriptors and method used. …”
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    Prediction of HIV-1 protease cleavage site from octapeptide sequence information using selected classifiers and hybrid descriptors
  9. 383689
    “…BACKGROUND: The utility of dipstick proteinuria for predicting microalbuminuria in non-diabetic lifestyle-related diseases compared with the urine protein-to-creatinine ratio (uPCR) and the effect of dipstick proteinuria on the cut-off value (CO) and accuracy of uPCR are unclear. METHODS: The subjects included Japanese patients ≥ 18 years old with lifestyle-related diseases who had an estimated glomerular filtration rate of ≥ 15 ml/min/1.73 m(2) and uPCR of < 0.5 g/gCr at initiation. …”
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    A comparison of the utility of the urine dipstick and urine protein-to-creatinine ratio for predicting microalbuminuria in patients with non-diabetic lifestyle-related diseases -a comparison with diabetes
  10. 383690
    “…Whereas LV function was modelled realistically using catheter measurements conducted on the same subject than the MR imaging, RV function was based on representative literature values for healthy and PAH rats with RV overload. …”
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    Assessment of left ventricular mechanics in right ventricular overload using in silico rat models
  11. 383691
    “…Combining ML feature selection with DL allows the identification of distinct factors in a unique ASIAN population for better mortality prediction than relying solely on an expert recommendation as it is a very subjective approach. Continuous validation on population-specific algorithms using DL and ML is needed before implementing in a real clinical setting. …”
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    Investigating performance of deep learning and machine learning risk stratification of Asian in-hospital patients after ST-elevation myocardial infarction
  12. 383692
    “…METHODS: The study population included 14,378 participants aged 30–60 years (8272 women) from three population-based cohort studies, including Atherosclerosis Risk in Communities, Multi-Ethnic Study of Atherosclerosis, and Tehran Lipid and Glucose Study. Subjects were classified into six categories based on the approximately three-year changes in FPG status: (1) normal FPG (NFG) to NFG (reference category); (2) NFG to impaired fasting glucose (IFG) (i.e., 126 > FPG ≥ 100 mg/dl); (3) NFG to T2DM; (4) IFG to NFG; (5) IFG to IFG; (6) IFG to T2DM. …”
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    Changes in Fasting plasma glucose status and risk of mortality events in individuals without diabetes over two decades of Follow-up: a pooled cohort analysis
  13. 383693
    “…MATERIAL AND METHODS: Eighteen eligible patients (F: 3, M: 15) were subjected to (90)Y therapy. (99m)Tc-MAA (111-222 MBq) was injected into the targeted liver, followed by whole-body scan (WBS) with peak-window at 140 keV (15% width) and one down-scatter window. …”
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    Simplification of dosimetry in (90)Y-radioembolization therapy by dual planar images
  14. 383694
    “…Survey studies were considered eligible if they investigated cervical cancer screening adherence among general women, with data on sample size, the number of adherent subjects, and/or adherence rate. Random-effects were used to pool the odds ratios (ORs) of associated factors of adherence. …”
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    Associated factors and global adherence of cervical cancer screening in 2019: a systematic analysis and modelling study
  15. 383695
    “…The secondary objectives were to assess the safety and tolerability of NMN supplementation, next to the evaluation of clinical efficacy by measuring physical performance (six-minute walking test), blood biological age (Aging.Ai 3.0 calculator), Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), and subjective general health assessment [36-Item Short Form Survey Instrument (SF-36)]. …”
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    The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial
  16. 383696
    “…When LINE-1 methylation was dichotomized as < 55% versus ≥ 55%, interaction with HPV16 emerged: compared with hypermethylated HPV16-positive patients, subjects with hypomethylated HPV16-negative OPSCC reported an adjusted higher risk of death (HR 4.83, 95% CI 2.24–10.38) and progression (HR 4.54, 95% CI 2.18–9.48). …”
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    LINE-1 hypomethylation is associated with poor outcomes in locoregionally advanced oropharyngeal cancer
  17. 383697
    “…CONCLUSION: Dans la législation française, la télé-otoscopie est un acte médical qui relève soit de la télé-expertise (avis asynchrone) soit d’un acte de téléconsultation (avis synchrone). L’évaluation subjective et objective de la fonction auditive du patient est aujourd’hui possible à distance à condition de respecter les précautions listées.…”
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    Téléconsultation médicale en audiologie. Conseils de bonnes pratiques de la Société française d’audiologie (SFA) et de la Société française d’ORL et de chirurgie cervico-faciale (SFORL)()
  18. 383698
    “…METHODS: We included 39,746 IHD patients from the regional Heart Registry that had been subjected to a coronary angiography between 2006 and 2017 with confirmed coronary artery disease. …”
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    PMHnet-alpha: development and validation of a neural network based discrete-time survival model for mortality prediction in ischemic heart disease
  19. 383699
    “…In multivariate analysis, for each additional evidence-based medicine training hour there was an increase of 0.28 points (95% CI 0.15–0.42) in primary outcome and in the change intrasubject each year of increase in age was associated with an improvement of 0.37 points and being a woman was associated with a 6.10-point reduction. 48 of the 104 subjects in the intervention group (46.2%, 95% CI: 36.5–55.8%) used the games during the month of the study. …”
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    Effectiveness of a game-based educational strategy e-EDUCAGUIA for implementing antimicrobial clinical practice guidelines in family medicine residents in Spain: a randomized clinical trial by cluster
  20. 383700
    “…A multidisciplinary network must be guaranteed to the affected subjects, to ensure adequate care and improve the quality of life for patients and their families.…”
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    Congenital syphilis in a preterm newborn with gastrointestinal disorders and postnatal growth restriction
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