“…PATIENTS AND METHODS: The study covered 138 adult patients. All patients were subjected to echocardiography evaluation after acute myocardial infarction during the period of follow up for 5 years. …”
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“…Overall, there was no statistical association between MDM2 SNP309 and prostate cancer risk for the allele contrast, the GG genotype, the recessive genetic model, the dominant genetic model, and prostate cancer risk in all subjects (OR = 0.96, 95% CI 0.87–1.05, P = 0.36; OR = 0.93, 95% CI 0.75–1.15, P = 0.50; OR = 1.00, 95% CI 0.87–1.15, P = 0.99; OR = 0.93, 95% CI 0.80–1.07, P = 0.30), and between MDM2 SNP309 and bladder cancer risk (the allele contrast: OR = 1.06, 95% CI 0.89–1.27, P = 0.50; the GG genotype: OR = 1.12, 95% CI 0.79–1.61, P = 0.52; the dominant genetic model: OR = 1.03, 95% CI 0.83–1.28, P = 0.78; the recessive genetic model: OR = 1.12, 95% CI 0.84–1.49, P = 0.45). …”
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“…Such future metabolic signatures will: (1) provide predictive, prognostic, diagnostic, and surrogate markers of diverse disease states; (2) inform on underlying molecular mechanisms of diseases; (3) allow for sub-classification of diseases, and stratification of patients based on metabolic pathways impacted; (4) reveal biomarkers for drug response phenotypes, providing an effective means to predict variation in a subject’s response to treatment (pharmacometabolomics); (5) define a metabotype for each specific genotype, offering a functional read-out for genetic variants: (6) provide a means to monitor response and recurrence of diseases, such as cancers: (7) describe the molecular landscape in human performance applications and extreme environments. …”
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“…Using a composite collection of 8871 clinically used drugs and well-annotated pharmacological compounds (including the LOPAC library, the FDA Approved Drug Library, the NIH Clinical Collection, the New Prestwick Chemical Library, the US Drug Collection, the International Drug Collection, the ‘Killer Plates’ collection and a small custom collection of PLP-dependent enzyme inhibitors), we conducted an in vitro screen in order to identify inhibitors for CBS using a primary 7-azido-4-methylcoumarin (AzMc) screen to detect CBS-derived hydrogen sulfide (H(2)S) production. Initial hits were subjected to counterscreens using the methylene blue assay (a secondary assay to measure H(2)S production) and were assessed for their ability to quench the H(2)S signal produced by the H(2)S donor compound GYY4137. …”
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“…LIMITATIONS REASONS FOR CAUTION: The study included only subjects with reduced total spermatozoa counts. Thus, these findings cannot be automatically applied to all male factor infertility cases. …”
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“…METHODS: The air-dried roots of Anethum sowa L. were subjected to hydro-distillation to yield the essential oil. …”
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“…Most studies (98%, 1041/1064) had results posted to one or more public registers, including all studies subject to FDAAA (Food and Drug Administration Amendments Act) requirements for posting to www.clinicaltrials.gov. …”
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“…The proposed method for testing the device efficiency employs a biofeedback from the subject by recording the biopotentials evoked by the laser stimulus at related distant SLB sites. …”
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“…The instrument’s specificity is also subject to spectrum bias and may change with variations in the proportion of “low-risk” patients seen in other centers. …”
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“…METHODS: One hundred thirty-nine subjects (99 female/40 male) with a mean age of 16.9±2.0 years old (range: 13-25 y/o) underwent ACLR with either a HS autograft (n=79) or a BTB autograft (n=60) and were released to return to pivoting/cutting sport. …”
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“…Most were male, had asymptomatic HIV infection, with median HIV-1 RNA 4.4–4.5 log(10) c/mL. The proportion of subjects with HIV-1 RNA <50 c/mL at W24 was 97% for the BIC arm and 94% for the DTG arm, and at W48 was 97% and 91%, respectively (Table). …”
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“…Secondly, we examined strength gain variations when performing multi-joint or isolation exercises, and probed for a potential relationship between weekly set number and stage of subjects’ training (trained versus untrained). METHODS: Computerised searches were performed on PubMed, MEDLINE, SWETSWISE, EMBASE and SPORTDiscus™ using the terms ‘strength training’, ‘resistance training’, ‘single sets’, ‘multiple sets’ and ‘volume’. …”
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“…METHODS: We evaluated VCE-003.2 in an in vivo [mice subjected to unilateral intrastriatal injections of lipopolysaccharide (LPS)] model of PD, as well as in in vitro (LPS-exposed BV2 cells and M-213 cells treated with conditioned media generated from LPS-exposed BV2 cells) cellular models. …”
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“…STUDY DESIGN, SIZE, DURATION: This double-blind randomized controlled trial (RCT) included 159 participants between April 2007 and June 2014. Subjects were randomly allocated to either CC (n = 79) or letrozole (n = 80) in a 1:1 ratio. …”
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“…Domain 4 (Behaviour) had the strongest association with Domain 5, whilst Domain 1 (Nutrition) had the weakest association with Domain 5, implying that the panellists considered commonly applied nutritional interventions to have less of a bearing on subjective mental state than commonly applied behavioural restrictions. …”
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“…RNA was extracted from decidual tissue and subjected to Illumina HT-12v4.0 BeadChip expression microarrays (TNL, n = 11; TL, n = 8; PTNL, n = 7; PTL, n = 10). …”
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“…In 36.8% of the friendship groups described, parent participants indicated that the majority of the members became transgender-identified. Parents reported subjective declines in their AYAs’ mental health (47.2%) and in parent-child relationships (57.3%) since the AYA “came out” and that AYAs expressed a range of behaviors that included: expressing distrust of non-transgender people (22.7%); stopping spending time with non-transgender friends (25.0%); trying to isolate themselves from their families (49.4%), and only trusting information about gender dysphoria from transgender sources (46.6%). …”
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“…Training on study insulin pump and continuous glucose monitoring took place over a 4-week run-in period. Eligible subjects were randomly assigned using central randomisation software. …”
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“…Of the 185 females, 36 (19.5%) came up with positive cultures, while 25 (12.6%) of the 199 males had significant bacteriuria, and the largest number of study subjects were below the age of 3 years, and the largest positive culture was obtained from this age group, accounting for 35 (57.4%.) out of 61 positive cultures. …”
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“…Confirmatory objectives were to evaluate humoral response rate to RZV and to compare humoral immune responses to RZV and PL at month 2 excluding either subjects with chronic lymphocytic leukemia and non-Hodgkin B-cell lymphoma (NHBCL), or only those with NHBCL. …”
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