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2461por Mackie, Sarah Louise, Pease, Colin Thomas, Fukuba, Eiji, Harris, Emma, Emery, Paul, Hodgson, Richard, Freeston, Jane, McGonagle, Dennis“…IL-6 levels ≥16.8 pg/mL had 86% sensitivity and 86% specificity for the extracapsular MRI pattern. CONCLUSIONS: A subset of patients with rheumatologist-diagnosed PMR had a characteristic, extracapsular pattern of MRI inflammation, associated with elevated IL-6/CRP and with complete patient-reported glucocorticoid responsiveness.…”
Publicado 2015
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2462por Magnusson, Maria K, Brynjólfsson, Siggeir F, Dige, Anders, Uronen-Hansson, Heli, Börjesson, Lars G., Bengtsson, Jonas L., Gudjonsson, Sigurdur, Öhman, Lena, Agnholt, Jørgen, Sjövall, Henrik, Agace, William W, Wick, Mary JoEnlace del recurso
Publicado 2015
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2463por Onyema, Oscar Okwudiri, Decoster, Lore, Njemini, Rose, Forti, Louis Nuvagah, Bautmans, Ivan, De Waele, Marc, Mets, Tony“…BACKGROUND: Shifts in CD8+ T-cell subsets that are hallmarks of immunosenescence are observed in ageing and in conditions of chronic immune stimulation. …”
Publicado 2015
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2464por Guasti, Luigina, Maresca, Andrea Maria, Schembri, Laura, Rasini, Emanuela, Dentali, Francesco, Squizzato, Alessandro, Klersy, Catherine, Robustelli Test, Laura, Mongiardi, Christian, Campiotti, Leonardo, Ageno, Walter, Grandi, Anna Maria, Cosentino, Marco, Marino, Franca“…A potential immuno-modulation by statin treatment is not achieved through a normalization in peripheral CD4 + cell subsets.…”
Publicado 2016
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2465por Lundberg, Kristina, Rydnert, Frida, Broos, Sissela, Andersson, Morgan, Greiff, Lennart, Lindstedt, Malin“…The modifications in phenotype and occurrence of specific DC subsets observed during AIT suggest an altered capacity of DC subsets to interact with allergens, which can be part of the mechanisms by which AIT induces allergen tolerance.…”
Publicado 2016
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2466por Holloway, Kimberly R., Sinha, Vidya C., Bu, Wen, Toneff, Michael, Dong, Jie, Peng, Yi, Li, Yi“…The contribution of the initiating oncogenic mutation to tumor phenotype remains controversial, largely due to the technical difficulties in delivering genetic alterations into well-defined subsets of mammary epithelial cells. To examine how different initiating oncogenes drive tumor phenotype, we somatically delivered two oncogenes (ErbB2, PyMT) into a narrow and distinct subset of the mouse mammary epithelium defined by the expression of the progenitor marker keratin 6a (Krt6a), and compared the phenotypes of the resulting mammary tumors. …”
Publicado 2016
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2467por Würsch, Daniela, Ormsby, Christopher E., Romero-Rodríguez, Dámaris P., Olvera-García, Gustavo, Zúñiga, Joaquín, Jiang, Wei, Pérez-Patrigeon, Santiago, Espinosa, Enrique“…The frequencies of the activated phenotypes %CD38(+) Ki67(−) and %CD38(+) Ki67(+) of the CXCR5(−) CXCR3(−) CCR4(+) (“pre-Th2”) central memory (T(CM)) cell subset clustered together, comprising a significant negative correlate of total circulating CD4(+) T cell counts and a positive correlate of viral load in multivariate analysis. …”
Publicado 2016
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2468por DeMaster, Laura K., Liu, Xiaohe, VanBelzen, D. Jake, Trinité, Benjamin, Zheng, Lingjie, Agosto, Luis M., Migueles, Stephen A., Connors, Mark, Sambucetti, Lidia, Levy, David N., Pasternak, Alexander O., O'Doherty, Una“…Gag(+) CD4(−) cells can also be detected in suppressed patients, suggesting that a subset of infected cells express proteins during ART. …”
Publicado 2016
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2469por Jones, R. Brad, Mueller, Stefanie, O’Connor, Rachel, Rimpel, Katherine, Sloan, Derek D., Karel, Dan, Wong, Hing C., Jeng, Emily K., Thomas, Allison S., Whitney, James B., Lim, So-Yon, Kovacs, Colin, Benko, Erika, Karandish, Sara, Huang, Szu-Han, Buzon, Maria J., Lichterfeld, Mathias, Irrinki, Alivelu, Murry, Jeffrey P., Tsai, Angela, Yu, Helen, Geleziunas, Romas, Trocha, Alicja, Ostrowski, Mario A., Irvine, Darrell J., Walker, Bruce D.Enlace del recurso
Publicado 2016
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2471por Ye, Sheng-Long, Chen, Xiaoping, Yang, Jiamei, Bie, Ping, Zhang, Shuijun, Liu, Fengyong, Liu, Luming, Zhou, Jie, Dou, Kefeng, Hao, Chunyi, Shao, Guoliang, Xia, Qiang, Chen, Yajin, Yang, Jijin, Deng, Xiaxing, Liu, Yunpeng, Yuan, Yunfei, Fu, Zhiren, Nakajima, Keiko, Yip, Christina S.M., Lu, Zhengguang“…We report data from the final analysis of the Chinese subset of the GIDEON (the Global Investigation of therapeutic DEcisions in hepatocellular carcinoma and Of its treatment with sorafeNib) study, which evaluated the safety and efficacy of sorafenib in Child-Pugh A, B and C patients with unresectable hepatocellular carcinoma (uHCC) in real-life clinical practice. …”
Publicado 2015
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2472por Samid, May Abd Al, Chaudhary, Belal, Khaled, Yazan S., Ammori, Basil J., Elkord, Eyad“…Regulatory T cells (Tregs) comprise numerous heterogeneous subsets with distinct phenotypic and functional features. …”
Publicado 2016
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2473por Fukumura, Kazuhiro, Wakabayashi, Shunichi, Kataoka, Naoyuki, Sakamoto, Hiroshi, Suzuki, Yutaka, Nakai, Kenta, Mayeda, Akila, Inoue, Kunio“…Taken together, we conclude that the EJC core assembled on pre-mRNA is critical for efficient and faithful splicing of a specific subset of short introns in mitotic cell cycle-related genes.…”
Publicado 2016
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2474por Bücklein, Veit, Adunka, Tina, Mendler, Anna N., Issels, Rolf, Subklewe, Marion, Schmollinger, Jan C., Noessner, Elfriede“…Furthermore, altered NK cell subset composition with reduced proportions of CD56(dim) cells could be demonstrated, increasing from 1st- to 2nd-line patients. 2nd-line patients additionally displayed significantly reduced expression of receptors (NKG2D), mediators (CD3ζ), and effectors (perforin) of NK cell activation. …”
Publicado 2016
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2475por Bell, Andrew S., Bradley, Joseph, Everett, Jeremy R., Loesel, Jens, McLoughlin, David, Mills, James, Peakman, Marie-Claire, Sharp, Robert E., Williams, Christine, Zhu, Hongyao“…Previously, we described a novel form of subset screening: plate-based diversity subset (PBDS) screening, in which the screening subset is constructed by plate selection (rather than individual compound cherry-picking), using algorithms that select for compound quality and chemical diversity on a plate basis. …”
Publicado 2016
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2476por Ikebuchi, Ryoyo, Teraguchi, Shunsuke, Vandenbon, Alexis, Honda, Tetsuya, Shand, Francis H. W., Nakanishi, Yasutaka, Watanabe, Takeshi, Tomura, Michio“…Single-cell profiling revealed that CD43(+) CCR5(+) Tregs represented the main subset within the Il10/Gzmb-expressing cell population in the dLN. …”
Publicado 2016
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2477por Lopez-Sejas, Nelson, Campos, Carmen, Hassouneh, Fakhri, Sanchez-Correa, Beatriz, Tarazona, Raquel, Pera, Alejandra, Solana, Rafael“…T-bet and Eomes are differentially expressed on NK cell subsets, and their expression is affected by CMV latent infection and aging.…”
Publicado 2016
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2478por Foltz, Jennifer A., Somanchi, Srinivas S., Yang, Yanwen, Aquino-Lopez, Arianexys, Bishop, Erin E., Lee, Dean A.“…In conclusion, we have identified and characterized canine NK cells, including an NKp46(−) subset of canine and human NK cells, using a novel anti-canine NKp46 antibody, and report robust ex vivo expansion of canine NK cells sufficient for adoptive immunotherapy.…”
Publicado 2016
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2479“…The variable importance feature is used to analyze and select optimal subsets of time-series MODIS imagery for efficient land cover mapping, and the outlier identification feature is utilized for transferring sample data available from one year to an adjacent year for supervised classification modelling. …”
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2480por Bottai, Giulia, Raschioni, Carlotta, Losurdo, Agnese, Di Tommaso, Luca, Tinterri, Corrado, Torrisi, Rosalba, Reis-Filho, Jorge S., Roncalli, Massimo, Sotiriou, Christos, Santoro, Armando, Mantovani, Alberto, Loi, Sherene, Santarpia, Libero“…CONCLUSIONS: Overall, our data indicate that the evaluation of stromal TILs remains the most reliable immune prognostic marker in TNBC, and support the clinical evaluation of anti-PD-1/PD-L1 and anti-LAG-3 in a subset of patients with TNBC who have concurrent expression of both checkpoint receptors. …”
Publicado 2016
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