“…New biomarkers are needed for the classification of SjS, thus, we aimed to evaluate the added-value of lymphocyte subpopulations in discriminating SjS and non-Sjögren Sicca patients. Lymphocyte subsets from 62 SjS and 63 Sicca patients were characterized by flow cytometry. …”
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“…In humans, there are three subsets of monocytes, namely, CD14++CD16− (Mon1), CD14++CD16+ (Mon2), and CD14+CD16++ (Mon3). …”
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“…However, the cellular mechanisms that drive NKT17 subset specification, and how iNKT cells in general acquire their effector function prior to antigen encounter, remain largely unknown. …”
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“…We analyzed NK population subsets by unsupervised dimensional reduction techniques in blood samples from breast tumor (BC) patients and healthy donors (HD). …”
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“…To investigate the proportion of each immune cell subpopulation, an unsupervised clustering method was employed, and T-distributed stochastic neighbor embedding was used to visualize the distinctions between different immune cell subsets. RESULTS: Through CyTOF test, we identified 10 immune cell subsets in the corneal tissues. …”
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“…Our study aimed to analyze lymphocyte subsets and levels of circulating cytokines in patients with RA with progressive bone erosions. …”
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“…Mass cytometry identified changes in 15 T‐cell subsets, with higher numbers of proliferating, highly differentiated and cytotoxic cells and decreases in naïve T cells. …”
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“…Analysis of whole skin cell subsets and fibroblast subpopulations across stage and ANA subgroup were used to interpret potential cellular differences anchored by these subgroups. …”
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“…The results provide information about properties common and unique to subsets of the list and hence insights into the biology of the problem under investigation.…”
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“…CD4 T cells are phenotypically divided by the expression of high and low molecular weight isoforms of CD45, surface markers that are frequently used to identify “naive” (CD45R(high)) and “memory” (CD45R(low)) subsets. The latter subset responds rapidly in antigen recall assays but paradoxically has a short life span, a property that is difficult to reconcile with long-term memory. …”
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“…This is supported by associated phenotypic and functional studies that suggest that the “true” RT6(-)T-cell subset contains antigenically naive and/or autoreactive clonotypes, whereas the RT6(+) T-cell subset contains memory and/or regulatory cells. …”
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“…CONCLUSION: NF-κB globally regulates diverse gene programs that are organized in signal networks and pathways differing in cancer subsets with distinct p53 status. The concerted alterations in gene expression patterns reflect cross-talk among NF-κB and other pathways, which may provide a basis for molecular classifications and targeted therapeutics for heterogeneous subsets of head and neck or other cancers.…”
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“…In the reduced-density marker subsets the ranking of the methods was generally consistent. …”
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“…BACKGROUND: Dendritic cells (DC) linking innate and adaptive immune responses are present in human lungs, but the characterization of different subsets and their role in COPD pathogenesis remain to be elucidated. …”
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“…The mouse and human epithelial subset signatures were then subjected to Ingenuity Pathway Analysis (IPA) to identify conserved pathways. …”
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“…In two publicly available data sets and one new data set, our approach identified subset(s) of reference genes with smaller empirical variance of the normalizing factor than in subsets identified using previously published methods. …”
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“…The phenotypic analysis of blood B cell subsets can be used to understand these alterations. …”
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“…Accordingly, CSCs should comprise only a small subset of the tumor cells, which feeds tumor growth. …”
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“…However, their independent functional contributions in distinct CD8(+) T cell subsets are not well understood. In this study, CD8(+) T cells in human peripheral blood- and lung-derived lymphocytes were analyzed for CD28 and NKG2D expression and function. …”
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“…They are a heterogeneous population of specialized T lymphocytes composed of different subsets. DX5(+)NKT cells are characterized by expression of the NK cell marker DX5 in the context of CD3. …”
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