“…These modifications in lipid homeostasis were related to increased production of Aβ peptides as well as augmented levels of tau and phosphorylated tau in primary neuronal cultures. This suite of APOE4-associated anomalies in lipid homeostasis and neurotoxic protein levels may be related to the accrued risk for AD in APOE4 carriers and provides novel insights into potential strategies for therapeutic intervention.…”
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“…The experimental results on the CEC2014 benchmark function test suite show that the proposed algorithm has good performance in most test functions, and its optimization accuracy and convergence performance are also better than BFA, artificial fish swarm algorithm (AFSA), genetic algorithm (GA), and PSO algorithm, etc. …”
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“…The spatial arrangement and conformation of the three DAE ligands are directed by the surface chemistry of the molecular metal oxide precursor with exclusive ligation of the photo-active antiparallel rotamer to the polyoxometalate (POM) while the integrity of the assembly in solution has been verified by a suite of spectroscopic techniques. Electrocyclisation of the three DAEs occurs sequentially and has been investigated using a combination of steady-state and time-resolved spectroscopies with the discovery of a photochemical cascade whereby rapid photoinduced ring closure is followed by electron transfer from the ring-closed DAE to the POM in the latent donor–acceptor system on subsequent excitation. …”
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“…We demonstrate its utility for analyzing a suite of phenotypes, including motility, development/size, fecundity, and feeding, and establish the package as a platform upon which to build future custom phenotypic modules. …”
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“…Furthermore, animal models, widely used to bridge the gap between in vitro systems and the clinical scenario, do not allow the upper and lower airways to be studied in isolation. We have developed a suite of culture media reproducing key features of the upper and lower airways, for the study of bacterial adaptation and evolution in different respiratory environments. …”
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“…Characters such as suprastomatal sori and probasidia that germinate without dormancy are now known to represent a suite of adaptations that have been derived multiple times within Pucciniales, most likely in response to tropical climates.…”
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“…These data can be used in conjunction with other datasets that describe a suite of ecosystem functions in different land-use types under variable management.…”
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“…Here we discovered two C. acuminata cytochrome P450 monooxygenases that catalyze regio-specific 10- and 11-oxidations of camptothecin, and demonstrated combinatorial chemoenzymatic C-H functionalizations of the camptothecin scaffold using the new enzymes to produce a suite of anticancer drugs, including topotecan (Hycamtin®) and irinotecan (Camptosar®). …”
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“…Using the Pearl River Delta as the research area, this study constructed an optimized pixel-scale regression model based on NPP-VIIRS (The Visible Infrared Imaging Radiometer Suite on the Suomi National Polar-Orbiting Partnership spacecraft) nighttime light data and CO(2) emissions data at the district and county levels for 2017. …”
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“…Multiple taxonomy files are generated for classification of KEGG organisms and viruses, and the Brite hierarchy viewer is used for taxonomy mapping, a variant of Brite mapping in the new KEGG Mapper suite. The taxonomy mapping enables analysis of, for example, how functional links of genes in the pathway and physical links of genes on the chromosome are conserved among organism groups.…”
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“…To distinguish disease-causing OLF variants from benign OLF variants, we first characterized the most prevalent population-based variants using a suite of cellular and biophysical assays, and identified two variants with features of aggregation-prone familial disease variants. …”
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“…Retaining the connection to Synthetic Biology CAD, an extension of the Infobiotics Workbench Suite was considered, with potential for the integration of genetic regulatory models and/or chemical reaction networks through Next Generation Stochastic Simulator (NGSS) Gillespie algorithms. …”
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“…This paper sheds new light on a region of Europe–Neolithic Ireland–for which our knowledge is particularly restricted as evidence from both Ireland and Britain in this period has been so far patchy and inconclusive. Using a suite of methods and refined criteria for traction identification, we present new and robust data on a large faunal assemblage from Kilshane, Co. …”
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“…The IPRO is then compared with four state-of-the-art swarm evolutionary algorithms with various characteristics on the CEC 2013 test suite. Experimental results demonstrate the competitive advantages of IPRO in convergence precision and speed when solving function optimization problems.…”
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“…There is no one size fits all approach that suits all patients at all stages, hence flexibility and a suite of resources and strategies is optimal.…”
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“…To meet these challenges, we present pairtools – a flexible suite of tools for contact extraction from sequencing data. …”
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“…In this work, we carry out simulations using the AWSEM (Associative memory, Water mediated, Structure and Energy Model)-Suite force field along with the 3SPN.2C force field for DNA to predict the structure of hERα and study its dynamics when binding to DNA and coactivators. …”
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“…Drawing from optically adaptive multilayer skins within biological organisms, we report a multilayered millifluidic interface for achieving a comprehensive suite of independent optical responses in buildings. …”
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“…External validation was performed using MonolixSuite software, using prediction-based and simulation-based diagnostics. …”
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