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20801por Dhakal, Santosh, Loube, Jeffrey, Misplon, Julia A., Lo, Chia-Yun, Creisher, Patrick S., Mulka, Kathleen R., Deshpande, Sharvari, Mitzner, Wayne, Klein, Sabra L., Epstein, Suzanne L.“…After IAV challenge, A/NP-rAd-vaccinated mice experienced significantly less morbidity, had lower pulmonary virus titers, and developed less pulmonary inflammation than unvaccinated or B/NP-rAd-vaccinated mice. …”
Publicado 2021
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20802por Andrade, Cherley Borba Vieira, Monteiro, Victoria Regina de Siqueira, Coelho, Sharton Vinicius Antunes, Gomes, Hanailly Ribeiro, Sousa, Ronny Paiva Campos, Nascimento, Veronica Muller de Oliveira, Bloise, Flavia Fonseca, Matthews, Stephen Giles, Bloise, Enrrico, Arruda, Luciana Barros, Ortiga-Carvalho, Tania Maria“…Low (10(3) PFU-ZIKV(PE243); low ZIKV) and high (5x10(7) PFU-ZIKV(PE243); high ZIKV) virus titers were injected into immunocompetent (ICompetent C57BL/6) and immunocompromised (ICompromised A129) mice at gestational day (GD) 12.5 for tissue collection at GD18.5 (term). …”
Publicado 2021
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20803por Piredda, Ivana, Ponti, Maria Nicoletta, Piras, Angela, Palmas, Bruna, Pintore, Pierangela, Pedditzi, Aureliana, Chisu, Valentina“…In addition, kidney homogenates from rodents collected from the same study area were also analyzed by culture-based and real-time PCR-based testing methods. Higher antibody titers were observed against Leptospira Icterohaemmorrhagiae, which is believed to be responsible for the majority of severe cases of leptospirosis in humans. …”
Publicado 2021
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20804“…Three hybridoma cell lines, 2D7, 3C2, and 4A10, were filtered, and their mAbs corresponded to an IgG1 isotype with a κ light chain. The mAbs titers were between (2.56 to 5.12) × 10(2) in supernatants and (1.28 to 5.12) × 10(5) in the ascites. …”
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20805por Ye, Xunyan, Iwuchukwu, Obinna P., Avadhanula, Vasanthi, Aideyan, Letisha O., McBride, Trevor J., Henke, David M., Patel, Kirtida D., Piedra, Felipe-Andres, Angelo, Laura S., Shah, Dimpy P., Chemaly, Roy F., Piedra, Pedro A.“…We measured (1) humoral IgG and mucosal IgA binding antibody levels to multiple RSV proteins (F, G, N, P, and M2-1) by Western blot (WB); (2) neutralizing antibody (Nt Ab) titers by microneutralization assay; and (3) palivizumab-like antibody (PLA) concentrations by an ELISA-based competitive binding assay developed in the lab. …”
Publicado 2021
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20806por Esperança‐Martins, Miguel, Gonçalves, Lisa, Soares‐Pinho, Inês, Gomes, Andreia, Serrano, Marta, Blankenhaus, Birte, Figueiredo‐Campos, Patrícia, Catarina‐Marques, Ana, Castro‐Barbosa, Ana, Cardoso, Ana, Antunes‐Meireles, Pedro, Atalaia‐Barbacena, Henrique, Gaspar, Pedro, Howell‐Monteiro, Patrícia, Pais‐de‐Lacerda, António, Mota, Catarina, Veldhoen, Marc“…All IgG, IgM, IgA, and total Ig antibody titers were significantly lower in patients with cancer compared with those without. …”
Publicado 2021
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20807por Yoon, Jee Hee, Shin, Min-ho, Kim, Hee Nam, Choi, Wonsuk, Park, Ji Yong, Hong, A Ram, Kim, Hee Kyung, Kang, Ho-Cheol“…In patients with GD, the A/G or G/G genotype group demonstrated higher TBII titer (20.6±20.5 vs. 28.0±25.8, P=0.044) and longer treatment duration (39.0±40.4 months vs. 62.4±65.0 months, P=0.003) compared to the A/A genotype group. …”
Publicado 2021
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20808por Malshe, Nandini, Patnaik, Suprabha K., Lalwani, Sanjay, Suryawanshi, Pradeep, Kulkarni, Ruta, Mhaske, Suhas, Mishra, Akhilesh Chandra, Arankalle, Vidya“…. ~ 75% IgG-positives exhibited neutralization potential with mean PRNT titers of 42.4 ± 24 (SARS-CoV-2-RNA+) and 72.3 ± 46.7 (SARS-CoV-2 RNA-negative); higher in the latter (p < 0.05). …”
Publicado 2021
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20809por Kotraiah, Vinayaka, Phares, Timothy W., Terry, Frances E., Hindocha, Pooja, Silk, Sarah E., Nielsen, Carolyn M., Moise, Leonard, Tucker, Kenneth D., Ashfield, Rebecca, Martin, William D., De Groot, Anne S., Draper, Simon J., Gutierrez, Gabriel M., Noe, Amy R.“…Recent development efforts with non-redundant, conserved blood stage antigens suggest both high antibody titer and rapid antibody binding kinetics are important efficacy factors. …”
Publicado 2021
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20810por Maeda, Kenji, Amano, Masayuki, Uemura, Yukari, Tsuchiya, Kiyoto, Matsushima, Tomoko, Noda, Kenta, Shimizu, Yosuke, Fujiwara, Asuka, Takamatsu, Yuki, Ichikawa, Yasuko, Nishimura, Hidehiro, Kinoshita, Mari, Matsumoto, Shota, Gatanaga, Hiroyuki, Yoshimura, Kazuhisa, Oka, Shin-ichi, Mikami, Ayako, Sugiura, Wataru, Sato, Toshiyuki, Yoshida, Tomokazu, Shimada, Shinya, Mitsuya, Hiroaki“…Correlates of BNT162b2-elicited SARS-CoV-2-neutralizing activity (50% neutralization titer: NT(50); assessed using infectious virions and live target cells) with SARS-CoV-2-S1-binding-IgG and -IgM levels, adverse effects (AEs), ages, and genders were examined. …”
Publicado 2021
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20811por van Haaren, M. M., McCoy, L. E., Torres, J. L., Lee, W., Cottrell, C. A., Copps, J. L., van der Woude, P., Yasmeen, A., de Taeye, S. W., Torrents de la Peña, A., Moore, J. P., Burton, D. R., Klasse, P. J., Ward, A. B., Sanders, R. W., van Gils, M. J.“…Four rabbits that were immunized three times with AMC008 trimer developed robust autologous and sporadic low-titer heterologous neutralizing responses. Seventeen AMC008 trimer-reactive MAbs were isolated using antigen-specific single B-cell sorting. …”
Publicado 2021
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20812por Wang, Xing, Wang, Dedao, Ding, Ning, Mi, Lan, Yu, Hui, Wu, Meng, Feng, Feier, Hu, Luni, Zhang, Yime, Zhong, Chao, Ye, Yingying, Li, Jiao, Fang, Wei, Shi, Yunfei, Deng, Lijuan, Ying, Zhitao, Song, Yuqin, Zhu, Jun“…Methods: Cell proliferation, cell cycle and apoptosis were analyzed by CellTiter-Glo Luminescent Cell Viability Assay and flow cytometry. …”
Publicado 2021
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20813por Holley, Joe, Sumner, Rebecca P., Lant, Sian, Ribeca, Paolo, Ulaeto, David, Maluquer de Motes, Carlos“…This process correlates with A26 association with the MV surface protein A27 and exclusion of F13, thus reducing EV titers. Thus, MV maturation is controlled by the abundance of the viral A26 protein, independently of other factors, and is rate limiting for EV production. …”
Publicado 2021
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20814“…The viability of the cells after treatment with varying concentrations of the drugs (E, D, and P) either alone or in combinations with M was determined using the CellTiter Glow assay after 72 h, and the combination index for each was calculated using Compusyn by the Chou–Talalay method. …”
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20815por Kastelic, Marjan, Pšeničnik, Igor, Gregurić Gračner, Gordana, Čebulj Kadunc, Nina, Lindtner Knific, Renata, Slavec, Brigita, Krapež, Uroš, Vergles Rataj, Aleksandra, Zorman Rojs, Olga, Pulko, Barbara, Rajšp, Maša, Mlakar Hrženjak, Nina, Dovč, Alenka“…Blood samples were collected, and HI antibody titers against paramyxoviruses before and 25 days after vaccination were determined. …”
Publicado 2021
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20816por Maraqa, Beesan, Basha, Walid, Khayyat, Rasha, Abdul-Hadi, Abdul-Rahman, Jabareen, Jurouh, Al-Shakhra, Kamal, Al-Kaila, Mai, Nazzal, Zaher“…IgM, IgG, and IgA-specific antibody titers were measured using ELISA. The overall prevalence (with 95% confidence intervals [CIs]) of SARS-CoV-2 total antibodies and specific antibodies were estimated. …”
Publicado 2021
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20817por Shiliaev, Nikita, Lukash, Tetyana, Palchevska, Oksana, Crossman, David K., Green, Todd J., Crowley, Michael R., Frolova, Elena I., Frolov, Ilya“…These viral adaptations result in higher affinity of viral particles to heparin, dramatic increase in plaque sizes, more efficient viral spread, higher infectious titers, and 2 orders of magnitude higher infectivity. …”
Publicado 2021
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20818por Kaur, Sandeep, Kumari, Anila, Kumari Negi, Anjana, Galav, Vikas, Thakur, Shikha, Agrawal, Manish, Sharma, Vandana“…All these new advances are aimed at creating a suitable housing system for therapeutic bacteriophage preparations while targeting the multiple issues of phage therapy i.e., improving phage stability and titers, improving in-vivo retention times, acting as suitable delivery systems for sustained release at target site of infection, improved penetration into biofilms and protection from immune cell attack. …”
Publicado 2021
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20819por Endale, Adugna, Medhin, Girmay, Darfiro, Koyamo, Kebede, Nigatu, Legesse, Mengistu“…It was found that preexisting immunity due to vaccination or prior flavivirus exposure to antigenetically related species enhanced the cross-reactive antibody titer. CONCLUSION: This review found the highest cross-reaction between DENV and non-DENV flaviviruses, especially yellow fever virus, and the least between chikungunya virus and DENV. …”
Publicado 2021
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20820por Michael, Husheem, Paim, Francine C., Langel, Stephanie N., Miyazaki, Ayako, Fischer, David D., Chepngeno, Juliet, Amimo, Joshua, Deblais, Loic, Rajashekara, Gireesh, Saif, Linda J., Vlasova, Anastasia N.“…Cipro given in therapeutic doses for a short term reduced serum and intestinal total and HRV-specific antibody titers, while EcN treatment alleviated this effect. …”
Publicado 2021
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