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  1. 20921
    “…The efficacy of 4sM2 was evaluated by determining survival rates, body weights and residual lung viral titers. Our studies demonstrate that the survival of mice immunized with 4sM2 was significantly higher (80–100% survival) than that of unimmunized mice (0% survival). …”
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    Heterosubtypic protective immunity against widely divergent influenza subtypes induced by fusion protein 4sM2 in BALB/c mice
  2. 20922
    “…Additionally we see allelic correlation with autoantibody titers for PTPN22 SNP rs2476601 and anti-citrullinated enolase peptide antibodies in carriers of HLA-DRB1*04 (Mann Whitney test P = 0.02) and between CDK6 SNP rs42041 and anti-CCP in non-carriers of HLA-DRB1*04 (Mann Whitney test P = 0.02). …”
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    Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis
  3. 20923
    “…KD-287 fulfilled the non-inferiority criteria for seroconversion rate (SCR) and geometric mean titer (GMT) of the neutralizing antibody, which were the primary endpoints, at 4 weeks after the third vaccination (95% CI: −1.00, 3.10 for the SCR difference and 10.8, 17.6 for the GMT ratio). …”
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    Safety and immunogenicity of a freeze-dried, Vero cell culture-derived, inactivated Japanese encephalitis vaccine (KD-287, ENCEVAC®) versus a mouse brain-derived inactivated Japanese encephalitis vaccine in children: a phase III, multicenter, double-blinded, randomized trial
  4. 20924
    “…RESULTS: Current HIV therapies reduce viral load during treatment but titers rebound after treatment is discontinued. We devised a new drug that has a long lasting effect after viral load reduction. …”
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    Long lasting control of viral rebound with a new drug ABX464 targeting Rev – mediated viral RNA biogenesis
  5. 20925
    “…In vivo, SIVmac239Opt replicated to high peak titers with an average of 1.2 × 10(8) viral RNA copies/ml at day 12 following intrarectal challenge, reaching set-point viremia of 1.2 × 10(6) viral RNA copies/ml by day 28. …”
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    Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides
  6. 20926
    “…In contrast, the highest Gag-specific antibody titers were seen in the AS(H) group. Mucosal antibody responses were sporadic. …”
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    First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus–Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens
  7. 20927
    “…At least, 99.6% of HPV‐16/18‐vaccines remained seropositive for anti‐HPV‐16/18 antibodies; anti‐HPV‐16 and ‐18 geometric mean titers were 1271.1 EU/mL (1135.8–1422.6) and 710.0 EU/ml (628.6–801.9), respectively. …”
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    Efficacy, immunogenicity, and safety of the HPV‐16/18 AS04‐adjuvanted vaccine in Chinese women aged 18–25 years: event‐triggered analysis of a randomized controlled trial
  8. 20928
    “…RESULTS: DNA Aβ42 trimer immunization led to high titer antibody responses in the nonhuman primate (NHP) model. …”
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    Evaluation of a DNA Aβ42 vaccine in adult rhesus monkeys (Macaca mulatta): antibody kinetics and immune profile after intradermal immunization with full-length DNA Aβ42 trimer
  9. 20929
    “…We recently engineered a single-cycle virus deleted in glycoprotein-D (ΔgD-2) that induces high-titer antibodies (Abs) that are non-neutralizing but activate the Fc receptor (FcR) to elicit antibody-dependent cellular cytotoxicity (ADCC). …”
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    Maternal Immunization with a Single-Cycle Herpes Simplex Virus (HSV) Candidate Vaccine, ΔgD-2, Protects Neonatal Mice from Lethal Viral Challenge
  10. 20930
    “…In accordance with a Th1 response high antigen-specific IgG2c titers were detected in the majority of surviving C57BL/6 mice. …”
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    Comparative analysis of humoral immune responses and pathologies of BALB/c and C57BL/6 wildtype mice experimentally infected with a highly virulent Rodentibacter pneumotropicus (Pasteurella pneumotropica) strain
  11. 20931
    por Costa-Pereira, Christiane, Campi-Azevedo, Ana Carolina, Coelho-dos-Reis, Jordana Grazziela, Peruhype-Magalhães, Vanessa, Araújo, Márcio Sobreira Silva, do Vale Antonelli, Lis Ribeiro, Fonseca, Cristina Toscano, Lemos, Jandira Aparecida, Malaquias, Luiz Cosme Cote, de Souza Gomes, Matheus, Rodrigues Amaral, Laurence, Rios, Maria, Chancey, Caren, Persi, Harold Richard, Pereira, Jorge Marcelo, de Sousa Maia, Maria de Lourdes, Freire, Marcos da Silva, Martins, Reinaldo de Menezes, Homma, Akira, Simões, Marisol, Yamamura, Anna Yoshida, Farias, Roberto Henrique Guedes, Romano, Alessandro Pecego Martins, Domingues, Carla Magda, Tauil, Pedro Luiz, Vasconcelos, Pedro Fernando Costa, Caldas, Iramaya Rodrigues, Camacho, Luiz Antônio, Teixeira-Carvalho, Andrea, Martins-Filho, Olindo Assis
    Publicado 2018
    “…Together with the PRNT titers, the top-two biomarkers led to a resultant memory status observed in 80% and 51% of volunteers in PV(day30-45) and PV(year1-9), contrasting with 0% and 29% found in NV(day0) and PV(year10-11), respectively. …”
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    Multi-parameter approach to evaluate the timing of memory status after 17DD-YF primary vaccination
  12. 20932
    “…Using this engineered strain, we demonstrated a high 2,3-BDO titer (81.0 g L(−1)) in a fed-batch fermentation using a high concentration of glucose as the sole carbon source. …”
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    A pyruvate carbon flux tugging strategy for increasing 2,3-butanediol production and reducing ethanol subgeneration in the yeast Saccharomyces cerevisiae
  13. 20933
    “…Remarkably, CD49d(high) CD4(+) T cells specifically helped B-1 cells, but not follicular memory B cells (CD27(+) CD43(−)CD1c(−)) or marginal zone B cells (CD27(+)CD43(−)CD1c(+)), produce IgM and IgG antibodies. In parallel, the titer of human anti-blood group A IgM was positively correlated with the frequency of CD49d(high) CD4(+) T cells. …”
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    Identification of Human B-1 Helper T Cells With a Th1-Like Memory Phenotype and High Integrin CD49d Expression
  14. 20934
    “…Similar neutralizing titers were observed between regimens, with a trend towards increased response frequencies in 4 mg DNA-IIV3. …”
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    DNA vaccine priming for seasonal influenza vaccine in children and adolescents 6 to 17 years of age: A phase 1 randomized clinical trial
  15. 20935
    “…Positive Predictive Values, Negative Predictive Values, sensitivity and specificity were also calculated relative to vaccination against Hepatitis B, comparing anti-HBs titers to vaccination reports. RESULTS: Most reported previous hospitalization (55%), occupational injuries (54%), sharing of personal items (45.8%), alcohol consumption (77.2%), multiple sexual partners in previous 12 months (39.8%), and no condom use during sexual intercourse in last 12 months (46.5%). …”
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    Epidemiology of HIV, syphilis, and hepatitis B and C among manual cane cutters in low-income regions of Brazil
  16. 20936
    “…Seroconversion rates were 98% for VBG and 95% for NVBG (P = 0.15). Median yellow fever titers were 320 (IQR 160, 640) in both groups post-vaccination. …”
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    2286. Revisiting Immune Interference: Evaluation of Immune Response to Yellow Fever Vaccine at Various Time Points Following Live-Attenuated Influenza Vaccination
  17. 20937
    “…Co-administration of rgp140/GLA-AF with HIV-MVA did not impact the frequency of binding antibody responses against subtype B gp160, C gp140 or E gp120 antigens (95%, 99%, 79%, respectively), but significantly enhanced the magnitude against subtype B gp160 (2700 versus 300, p<0.001) and subtype C gp140 (24300 versus 2700, p<0.001) Env protein. At relatively low titers, neutralizing antibody responses using the TZM-bl assay were more frequent in vaccinees given adjuvanted protein boost. …”
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    Optimizing the immunogenicity of HIV prime-boost DNA-MVA-rgp140/GLA vaccines in a phase II randomized factorial trial design
  18. 20938
    “…METHODS: In vitro cell proliferation was analyzed using Cell Titer-Glo Luminescent Cell Viability Assay. Induction of apoptosis and cell cycle arrest were measured by flow cytometry. …”
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    Combination of Enzastaurin and Ibrutinib synergistically induces anti-tumor effects in diffuse large B cell lymphoma
  19. 20939
    “…Twenty-one of 28 children (75%) achieved a 3-fold increase in post-vaccination TV IgG levels, whereas only 3% achieved a 4-fold increase in PPV IgG post vaccination, mainly due to high baseline PPV IgG titers. When we classified children according to their response to TV as responders or non-responders and compared this with the well-known clinical warning signs of the Jeffrey Modell Foundation. …”
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    Measurement of Typhim Vi IgG as a Diagnostic Tool to Determine Anti-polysaccharide Antibody Production Deficiency in Children
  20. 20940
    “…By subsequent fermentation evaluation, a mutant RS3 with significantly improved lysine production capacity was selected. The final titer, yield and total amount of lysine produced by RS3 in a 5-L batch fermentation reached 155.0 ± 1.4 g/L, 0.59 ± 0.02 g lysine/g glucose, and 605.6 ± 23.5 g, with improvements of 14.8%, 9.3%, and 16.7%, respectively. …”
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    GREACE-assisted adaptive laboratory evolution in endpoint fermentation broth enhances lysine production by Escherichia coli
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