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  1. 101
    “…However, fragmentation of axial elements alone was not a good indicator of cell demise. Cleaved PARP-1 and TUNEL staining were not necessarily coincident, showing that TUNEL is not a reliable marker of apoptosis in oocytes. …”
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    Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one
  2. 102
    “…The number of total and TUNEL-positive osteocytes, and the average ratio of TUNEL-positive cells were calculated and analyzed according to the cause. …”
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    Apoptosis in the Osteonecrosis of the Femoral Head
  3. 103
    “…BAPTA-AM blocked increased TUNEL reactivity, superoxide and H(2)O(2) formation, while Trolox also blocked increased TUNEL reactivity increased after pFUS. mtTEMPOL allowed H(2)O(2) formation and did not block increased TUNEL reactivity after pFUS. …”
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    Cytosolic Ca(2+) transients during pulsed focused ultrasound generate reactive oxygen species and cause DNA damage in tumor cells
  4. 104
    “…The number of regenerating neurites was counted after 7 days of culture, followed by performing TUNEL and DAPI staining. The ratio of TUNEL-positive cells to the number of DAPI-stained nuclei was calculated. …”
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    Combination of Neuroprotective and Regenerative Agents for AGE-Induced Retinal Degeneration: In Vitro Study
  5. 105
    “…At 4 h after the treatment, many damaged cells were already observed in the colonic epithelium, and they were positive by TUNEL staining. At 8 h, the number of TUNEL‐positive cells was largest. …”
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    Early Alterations of Apoptosis and Cell Proliferation in Azoxymethane‐initiated Rat Colonic Epithelium
  6. 106
    “…Cells characterized by chromatin condensation were TUNEL‐positive in both treated and untreated cases with the exception of the MMC‐treated WiDr case, in which many TUNEL‐positive cells were observed without cytomorphological changes. …”
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    The TdT‐mediated dUTP Nick End Labeling Assay Precisely Assesses the DNA Damage in Human Tumor Xenografts
  7. 107
    “…We investigated the use of the polyphenol-rich, high-antioxidant-capacity fruit acai as a treatment for elevated sperm DNA fragmentation (>16%), measured by terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL). Following ≥ 74 days of treatment, we observed a significant decrease in sperm DNA fragmentation (−17.0% ± 2.5%) to 11.9 ± 1.7% (0–37%), with a 68.6% success rate (defined as post-treatment TUNEL < 16%). …”
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    Mitigating the Effects of Oxidative Sperm DNA Damage
  8. 108
    “…Stomach tissue was also evaluated using the TUNEL assay. RESULTS: In vitro, increased concentrations of MB led to higher TUNEL scores. …”
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    In vitro and in vivo phototoxicity on gastric mucosa induced by methylene blue
  9. 109
    “…Time course of the RIPK1 expression was similar to that of apoptosis detected by TUNEL. Interestingly, the increased expression of RIPK1 was rarely observed in the TUNEL-positive cells. …”
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    Changes in Expression of Receptor-Interacting Protein Kinase 1 in Secondary Neural Tissue Damage Following Spinal Cord Injury
  10. 110
    “…Sperm DNA fragmentation was studied using the TUNEL assay. The patients were split into four groups based on male age and sperm DNA fragmentation, as follows: Group 1: ≤39 years and TUNEL assay ≤20%; Group 2: ≤39 years and TUNEL assay >20%; Group 3: ≥40 years and TUNEL assay ≤20%; and Group 4: ≥40 years and TUNEL assay >20%. …”
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    Sperm DNA fragmentation and male age: results of in vitro fertilization treatments
  11. 111
    “…CONCLUSIONS: CC-3 and TUNEL levels within dermal appendages align with burn depth classification by H&E staining, wherein appendages graded as necrotic had higher levels of CC-3 and lower levels of TUNEL. …”
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    74 Secondary Immunohistochemical Analysis of Viable Cells as Determined by Hematoxylin and Eosin Staining
  12. 112
    “…Ki67 labelling index and TUNEL levels were directly correlated both at baseline and surgery (Spearman's r=0.51, P<0.0001). …”
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    The effect of metformin on apoptosis in a breast cancer presurgical trial
  13. 113
    “…TUNEL staining was located mostly in the deeper stroma and in few cases the peripheral stroma. …”
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    Keratocyte loss in corneal infection through apoptosis: a histologic study of 59 cases
  14. 114
    “…There were more TUNEL-positive cells ratio in the MTX 150 mg/kg group than in the MTX 5 mg/kg group. …”
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    Effect of methotrexate on rostral migratory stream in newborn rats
  15. 115
    “…By day 2, fibronectin and TUNEL staining diminished and a distinct acellular zone was present in the region of previously TUNEL-positive cells. …”
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    Keratocyte Apoptosis and Not Myofibroblast Differentiation Mark the Graft/Host Interface at Early Time-Points Post-DSAEK in a Cat Model
  16. 116
    “…In the dMGB, TUNEL was statistically significant elevated 24 h postexposure. …”
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    Time course of cell death due to acoustic overstimulation in the mouse medial geniculate body and primary auditory cortex
  17. 117
    “…At 2 and 4 weeks after injury, muscles were examined histologically and apoptosis was measured using TUNEL assay and PCR array for a range of apoptotic genes. …”
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    Anti-apoptotic effect of adipose tissue-derived stromal vascular fraction in denervated rat muscle
  18. 118
    “…Compared with sham-operated group (sham group), TUNEL-positive cells, MDA, and level of CaM activity increased in ischemia-reperfusion group (I/R group) and PCr preconditioning group (PCr group); compared with I/R group, TUNEL-positive cells, MDA content, and level of CaM activity decreased in PCr group. …”
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    Phosphocreatine Preconditioning Attenuates Apoptosis in Ischemia-Reperfusion Injury of Rat Brain
  19. 119
    “…In addition, a double-labeling experiment with TUNEL staining and immunofluorescence revealed the co-localization of nuclear AIF-positive and TUNEL-labeled cells. …”
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    Differential expression of apoptosis-related factors induces the age-related apoptosis of the gracilis muscle in humans
  20. 120
    “…To determine whether cleaved caspase‐3 expression in these glial cells was associated with apoptosis, a TUNEL assay was completed. TUNEL staining was negligible in all groups and did not mirror the pattern of caspase‐3 labeling. …”
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    Astrocytes and radial glia‐like cells, but not neurons, display a nonapoptotic increase in caspase‐3 expression following exercise
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