“…Background: This paper assesses obesity- and smoking-related incremental healthcare costs for the employees and dependents of a large U.S. employer. Objectives: Unlike previous studies, this study evaluates the distributional effects of obesity and smoking on healthcare cost distribution using a recently developed econometric framework: the unconditional quantile regression (UQR). …”
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“…The results show that the work safety information disclosure of listed companies in high-risk industries has a positive impact on corporate financial performance, safety performance and social reputation; unabsorbed slack resources have a positive U-shaped regulatory effect on work safety information disclosure and enterprise social reputation; The shareholding ratio of institutional investors has an inverted U-shaped regulatory effect on the positive relationship between work safety information disclosure and enterprise social reputation. …”
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“…In this study, we confirm that small datasets of BOs can be segmented with a light U-Net method almost as accurately as with the original method.…”
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“…It highlights different approaches, such as destructive and non-destructive processes, to be adopted to estimate the torsional parameters of a ferrocement “U” wrapped beam. The destructive method is the experimental determination of parameters, which is absolutely necessary. …”
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“…MTL network is implemented as a shared U-net encoder between the classification and the segmentation tasks. …”
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“…To obtain better detection accuracy, k-means++ clustering algorithm, a BiFPN-based feature fusion network, the convolutional block attention module (CBAM), and a CIoU loss function were proposed to improve the YOLOv5s model, and an attentional multi-scale cascaded feature fusion-based YOLOv5s model (AMCFF-YOLOv5s) was subsequently developed. …”
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“…We then provide the structural basis of this function with a high-resolution cryo-EM structure of nsP1 in complex with the unconventional cap-1 substrate RNA m(7)GpppA(m)U. We show that the 5′ppRNA species generated by decapping can trigger retinoic acid–inducible gene I–mediated interferon response. …”
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“…A membrane-tethered plasminogen activator inhibitor-1, which has the same binding site in vitronectin as uPAR, replicated uPAR-induced changes. A direct uPAR–vitronectin interaction is thus both required and sufficient to initiate downstream changes in cell morphology, migration, and signal transduction. …”
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“…Modelling of GIR1 based on new biochemical and mutational data shows an extended substrate domain containing a GoU pair distinct from the nucleophilic residue that dock onto a catalytic core showing a different topology from that of group I ribozymes. …”
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“…One group was treated with botulinum toxin-A 10 U by multiple submucosal gastric injections, while the second group was injected with saline. …”
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“…Furthermore, unlike intended gene silencing (RNA interference), off-target effect was completely abolished by introduction of a G:U pair into the seed duplex, and this loss in activity was completely recovered by a second mutation regenerating Watson–Crick pairing, indicating that seed duplex Watson–Crick pairing is also essential for off-target gene silencing. …”
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“…All 44 isolates were identified as O1 El Tor Ogawa, positive for various toxigenic and pathogenic genes viz. ace, ctxB, hlyA, ompU, ompW, rfbO1, rtx, tcpA, toxR and zot. Nucleotide sequencing revealed the presence of cholera toxin B of classical biotype in all the El Tor isolates, suggesting infection of isolates by classical CTXΦ. …”
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“…The genomes of commonly used variants of human cytomegalovirus (HCMV) strains Towne and AD169 each contain a substantial mutation in which a region (U(L)/b′) at the right end of the long unique region has been replaced by an inverted duplication of a region from the left end of the genome. …”
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“…This did not occur when splicing was inhibited with U2 snRNA AMO or the U2 snRNP inactivating drug, spliceostatin A, unless U1 AMO was also included. We further show that U1 snRNA-pre-mRNA base pairing was required to suppress PCPA from nearby cryptic PASs located in introns. …”
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“…The TFT/A pair was not cleaved by MUG, while the other pairs, namely, 5FU/A, 5FU/G, BrdU/A, BrdU/G, and TFT/G, were easily cleaved from each synthesized DNA. …”
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“…Here, using the regenerating adult zebrafish caudal fin as a model, we have demonstrated an involvement of the circadian clock in timing cell proliferation following injury. Using a BrdU incorporation assay with a short labeling period, we reveal high amplitude daily rhythms in S-phase in the epidermal cell layer of the fin under normal conditions. …”
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