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Mostrando 1,081 - 1,100 Resultados de 3,321 Para Buscar '"t.A.T.u."', tiempo de consulta: 1.44s Limitar resultados
  1. 1081
    “…The mutation mechanism had previously been shown to depend upon transcription initiation, suggesting that a mutator factor was loaded on an RNA polymerase initiating at the promoter and causing mutations during elongation (Peters, A., and U. Storb. 1996. Immunity. 4:57–65). To further elucidate this process we have created an artificial substrate consisting of alternating EcoRV and PvuII restriction enzyme sites (EPS) located within the variable (V) region of an Ig transgene. …”
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    A Hypermutable Insert in an Immunoglobulin Transgene Contains Hotspots of Somatic Mutation and Sequences Predicting Highly Stable Structures in the RNA Transcript
  2. 1082
    “…The low nPTB expression was due to the high proportion of codons with A or U at the third codon position, which are suboptimal in human mRNAs. …”
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    Expression of Human nPTB Is Limited by Extreme Suboptimal Codon Content
  3. 1083
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    Characterisation of the GRAF gene promoter and its methylation in patients with acute myeloid leukaemia and myelodysplastic syndrome
  4. 1084
    “…PCR detected ompW and toxR gene regions but not the ctxA, ompU, omp K and TCP gene regions. Although the organisms lacked flagellae on scanning electron microscopy, they possessed the Vibrio flagellin flaA gene. …”
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    Fatal bacteremia due to immotile Vibrio cholerae serogroup O21 in Vientiane, Laos – a case report
  5. 1085
    “…METHODS: Two markers, a dinucleotide polymorphism in exon 2 and a functional uVNTR on the promoter of the MAOA gene, were used to study the genetic association in 108 unrelated patients with BPD and 103 healthy controls. …”
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    Association analysis of monoamine oxidase A gene and bipolar affective disorder in Han Chinese
  6. 1086
    “…The brain magnetic resonance imaging (MRI) showed abnormally high signal intensities in the white matter tract, including a subcortical U fiber on the T2-weighted and fluid attenuated inversion recovery (FLAIR) image. …”
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    Identification of Proteolipid Protein 1 Gene Duplication by Multiplex Ligation-Dependent Probe Amplification: First Report of Genetically Confirmed Family of Pelizaeus-Merzbacher Disease in Korea
  7. 1087
    “…We have favored a major G-quadruplex form by a judicious U-for-T substitution in the sequence and determined the folding topology of this form. …”
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    A novel chair-type G-quadruplex formed by a Bombyx mori telomeric sequence
  8. 1088
    “…Phylogenetic analyses revealed a strict restriction at position 39 of the aptamer that prevents the G39–C65 and A39–U65 combinations, and mutational studies indicate that aptamers with these sequence combinations are impaired for ligand binding. …”
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    Riboswitch structure: an internal residue mimicking the purine ligand
  9. 1089
    “…Antitermination was abolished when Tϕ was mutated to lack a C + U stretch, but restored when abortive transcript sequence was additionally modified to complement the mutation in Tϕ, both in vitro and in vivo. …”
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    Tiny abortive initiation transcripts exert antitermination activity on an RNA hairpin-dependent intrinsic terminator
  10. 1090
    “…Moreover, we have identified a poly(U) polymerase, PUP-2, which regulates the stability of LIN-28 blockaded let-7 pre-miRNA, and contributes to lin-28 dependent regulation of let-7 during development. …”
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    LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans
  11. 1091
    “…The biological effect of a selection of the modified aptamers was tested by a thrombin time assay and showed that most of the UNA-modified TBAs possess anticoagulant properties, and that the construct with a UNA-U monomer in position 7 is a highly potent inhibitor of fibrin-clot formation.…”
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    Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer
  12. 1092
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    Genetic Characteristics, Coreceptor Usage Potential and Evolution of Nigerian HIV-1 Subtype G and CRF02_AG Isolates
  13. 1093
    “…More than 40000 samples, profiled by Affymetrix U133A or U133plus2 platforms in many different laboratories across the world, were collected from public resources and combined into two large data sets, helping the identification of cancer outliers that are over-expressed in only a subset of patients. …”
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    GENT: Gene Expression Database of Normal and Tumor Tissues
  14. 1094
    “…The antileukemia potential of BJO was investigated in human acute myeloid leukemia cell lines (AML) U937 and HL-60 in vitro and in a mouse U937 xenograft tumor model. BJO induced AML cell apoptosis through activation of caspase-8 and modulation of apoptosis-related proteins. …”
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    Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
  15. 1095
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    Distinct Proteasome Subpopulations in the Alveolar Space of Patients with the Acute Respiratory Distress Syndrome
  16. 1096
    “…To clarify this, we produced a congenic strain carrying MHC class II ‘a' and ‘u' haplotypes on the Komeda diabetes-prone (KDP) genetic background. …”
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    Role of major histocompatibility complex class II in the development of autoimmune type 1 diabetes and thyroiditis in rats
  17. 1097
    “…In addition, the antibody to PRPF40A precipitated U2 snRNPs from nuclear extracts, indicating that PRPF40A associates with U2 snRNPs.…”
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    Functional mammalian spliceosomal complex E contains SMN complex proteins in addition to U1 and U2 snRNPs
  18. 1098
    “…We show for seven human cell lines that about half of the genome is divided in domains that display a characteristic U-shaped replication timing profile with early initiation zones at borders and late replication at centers. …”
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    Replication Fork Polarity Gradients Revealed by Megabase-Sized U-Shaped Replication Timing Domains in Human Cell Lines
  19. 1099
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    Preferential Fas-mediated apoptotic execution at G(1) phase: the resistance of mitotic cells to the cell death
  20. 1100
    “…We previously showed that highly functional siRNAs possessed the following characteristics: A or U residues at nucleotide position 1 measured from the 5′ terminal, four to seven A/Us in positions 1–7, and G or C residues at position 19. …”
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    Thermodynamic Control of Small RNA-Mediated Gene Silencing
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