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1421
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1422Publicado 1992“…We have recently described a novel cDNA, SR13 (Welcher, A. A., U. Suter, M. De Leon, G. J. Snipes, and E. M. …”
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1423
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1424“…Similarly, 11 percent, 14 percent, and 70 percent, respectively, had CA125 levels above 35 U/ml (low cut-off), and less than 1.9 percent, 1.2 percent, and 49 percent had levels above a 200 U/ml (high cut-off). Ideally, the higher UGF and CA125 cut-offs should be used for diagnostic applications, like differentiation of a benign from a malignant pelvic mass (false-positive rate: UGF, less than 1.1 percent; CA125, 1.2 percent), but raising the cut-offs diminishes sensitivities for malignancy (UGF, 59 percent; CA125, 49 percent). …”
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1425por Lee, Yohan, Scheck, Adrienne C, Cloughesy, Timothy F, Lai, Albert, Dong, Jun, Farooqi, Haumith K, Liau, Linda M, Horvath, Steve, Mischel, Paul S, Nelson, Stanley F“…METHODS: We collected 267 GBM CEL files and normalized them relative to other microarrays of the same Affymetrix platform. 377 probesets on U133A and U133 Plus 2.0 arrays were used in a gene voting strategy with 177 probesets of matching genes on older U95Av2 arrays. …”
Publicado 2008
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1426
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1427“…The long D stem includes unique A14:U21 and G15:C20a pairs. The D-loop:T-loop interactions include the base pairs G18:U55 and U16:U59, and a unique base triple, U20:G19:C56. …”
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1428por Pearce, C L, Near, A M, Van Den Berg, D J, Ramus, S J, Gentry-Maharaj, A, Menon, U, Gayther, S A, Anderson, A R, Edlund, C K, Wu, A H, Chen, X, Beesley, J, Webb, P M, Holt, S K, Chen, C, Doherty, J A, Rossing, M A, Whittemore, A S, McGuire, V, DiCioccio, R A, Goodman, M T, Lurie, G, Carney, M E, Wilkens, L R, Ness, R B, Moysich, K B, Edwards, R, Jennison, E, Kjaer, S K, Hogdall, E, Hogdall, C K, Goode, E L, Sellers, T A, Vierkant, R A, Cunningham, J M, Schildkraut, J M, Berchuck, A, Moorman, P G, Iversen, E S, Cramer, D W, Terry, K L, Vitonis, A F, Titus-Ernstoff, L, Song, H, Pharoah, P D P, Spurdle, A B, Anton-Culver, H, Ziogas, A, Brewster, W, Galitovskiy, V, Chenevix-Trench, GEnlace del recurso
Publicado 2009
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1429
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1430por Liu, Yuchuan, Pixley, Robin, Fusaro, Mario, Godoy, Gustavo, Kim, Erin, Bromberg, Michael E., Colman, Robert W.“…These novel data indicate that HKa and D5 inhibit migration and invasion of human prostate cancer cells via a EGFR/uPAR pathway, suggesting the therapeutic potential of HKa and D5 to decrease metastasis of human prostate cancer.…”
Publicado 2009
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1431por Tsai, Kuen-Jer, Yang, Chun-Hung, Fang, Yen-Hsin, Cho, Kuan-Hung, Chien, Wei-Lin, Wang, Wei-Ting, Wu, Tzu-Wei, Lin, Ching-Po, Fu, Wen-Mei, Shen, Che-Kun James“…TDP-43 has also been identified as the major constituent of the neuronal cytoplasmic inclusions (NCIs) that are characteristic of a range of neurodegenerative diseases, including the frontotemporal lobar degeneration with ubiquitin(+) inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). We have generated a FTLD-U mouse model (CaMKII-TDP-43 Tg) in which TDP-43 is transgenically overexpressed in the forebrain resulting in phenotypic characteristics mimicking those of FTLD-U. …”
Publicado 2010
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1432
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1433
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1434por Peng, Roger D., Bobb, Jennifer F., Tebaldi, Claudia, McDaniel, Larry, Bell, Michelle L., Dominici, Francesca“…OBJECTIVES: We estimated the future excess mortality attributable to heat waves under global climate change for a major U.S. city. METHODS: We used a database comprising daily data from 1987 through 2005 on mortality from all nonaccidental causes, ambient levels of particulate matter and ozone, temperature, and dew point temperature for the city of Chicago, Illinois. …”
Publicado 2011
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1435por Annavarajula, S. K., Murty, K. V. D., Prayaga, A., Das, U., Desai, M., Narain, C. A.Enlace del recurso
Publicado 2011
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1436“…Gefitinib treatment did not alter the number of EGFR or HER2 expressed in tumor cell lines A431, U343, SKOV3 and SKBR3. Real-time binding traces were further analyzed in a novel tool, Interaction Map, which deciphered the different components of the measured interaction and supports EGF binding to multiple binding sites. …”
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1437por Edwards, John, Malaurie, Emilie, Kondrashov, Alexander, Long, Jed, de Moor, Cornelia H., Searle, Mark S., Emsley, Jonas“…A construct (T187) containing both binding domains (RRM1 and RRM2) was systematically studied for interaction with tandem UGU RNA binding sites with different length linker sequences UGU(U)(x)UGU where x = 1–7. A single U spacer results in interactions only with RRM1, demonstrating both steric constraints in accommodating both RRMs simultaneously at adjacent sites, and also subtle differences in binding affinities between RRMs. …”
Publicado 2011
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1438“…Because most plant miRNAs have a 5′U, AGO1 plays many essential roles in miRNA-mediated regulation of development and stress responses. …”
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1439por Croizier, Sophie, Amiot, Clotilde, Chen, Xiaoping, Presse, Françoise, Nahon, Jean-Louis, Wu, Jane Y., Fellmann, Dominique, Risold, Pierre-Yves“…However, these ascending and descending projections originate from distinct sub-populations expressing or not “Cocaine-and-Amphetamine-Regulated-Transcript” (CART) peptide. Using a BrdU approach, MCH cell bodies are among the very first generated in the hypothalamus, within a longitudinal cell cord made of earliest delaminating neuroblasts in the diencephalon and extending from the chiasmatic region to the ventral midbrain. …”
Publicado 2011
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1440