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  1. 1901
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    Why complicate an important task? An orderly display of the limb leads in the 12-lead electrocardiogram and its implications for recognition of acute coronary syndrome
  2. 1902
    por Je, Mikyung, Kim, Hayeon, Son, Hyeon S.
    Publicado 2019
    “…RESULTS: Analysis of nucleotide composition indicated that AfuPmV-1 had the highest GC content among analyzed mycoviruses and relative synonymous codon usage analysis indicated that all of the codons preferred by AfuPmV-1 ended with C or G, while codons ending with A or U were not observed. Moreover, the effective number of codons, the codon adaptation index, and correspondence analysis showed that AfuPmV-1 had greater codon preference compared with other mycoviruses and that AfuPmV-1 had relatively high adaptability to humans and fungi. …”
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    Analysis of the codon usage pattern of the RdRP gene of mycovirus infecting Aspergillus spp.
  3. 1903
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    Vilnius Declaration on chronic respiratory diseases: multisectoral care pathways embedding guided self-management, mHealth and air pollution in chronic respiratory diseases
  4. 1904
    “…Second, this network was applied to the remaining slides to create the reference standard used to train a second U-Net on H&E. Our system accurately segmented both intact glands and individual tumour epithelial cells. …”
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    Epithelium segmentation using deep learning in H&E-stained prostate specimens with immunohistochemistry as reference standard
  5. 1905
    “…Six distinct maternal lineages (H11a1, U4d2, J1c15, U6a1a1, T2b, and N1a3a) with different phylogenetic background were identified, pointing out the heterogeneous genetic aspect of the analyzed medieval group. …”
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    Mitochondrial ancestry of medieval individuals carelessly interred in a multiple burial from southeastern Romania
  6. 1906
    “…Further, the orthotopic GBM was successfully resected in small animals guided by the NIR-II FLI. By using a small uPAR targeting NIR-II probe, FLI allows us to specifically image and detect GBM. …”
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    Molecular Targeted NIR-II Probe for Image-Guided Brain Tumor Surgery
  7. 1907
    “…Depletion of TDP-43, in contrast, shifted the localization of these C/D scaRNAs, mainly into the nucleolus, as well as destabilizing scaRNA2, and reduced the site-specific 2′-O-methylation of U1 and U2 snRNAs, including at 70A in U1 snRNA and, 19G, 25G, 47U and 61C in U2 snRNA. …”
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    TDP-43 regulates site-specific 2′-O-methylation of U1 and U2 snRNAs via controlling the Cajal body localization of a subset of C/D scaRNAs
  8. 1908
    “…Lineage tracing analysis with a BrdU-labeled neonatal piglet showed that the proportion of BrdU-labeled cells in conducting airways decreased over the 90-day period of lung maturation. …”
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    Phenotypic Analysis of BrdU Label-Retaining Cells during the Maturation of Conducting Airway Epithelium in a Porcine Lung
  9. 1909
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    Use of bioengineered human commensal gut bacteria‐derived microvesicles for mucosal plague vaccine delivery and immunization
  10. 1910
    “…Women with 5+ births had greater risk of CHD (1.29, 1.10–1.52) and hospitalized MI (1.38, 1.13–1.69), after adjustment for baseline characteristics and breastfeeding. Conclusions: In a diverse U.S. cohort, a history of 5+ live births is associated with CHD risk, specifically, MI, independent of breastfeeding. …”
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    The Association Between Parity and Subsequent Cardiovascular Disease in Women: The Atherosclerosis Risk in Communities Study
  11. 1911
    “…Moreover, AOA-induced cellular senescence in WI38 cells is associated with elevated protein levels of p53, p21(CIP1) and p16(INK4A) and decreased Rb protein level, which was blocked by αKG supplementation. In p16(INK4A)-deficient U2OS human osteosarcoma cells and p16(INK4A)-knockdown WI38 cells, AOA exposure also induced similar effects on cell proliferation, and protein level of P-Rb-S807/811 and Rb. …”
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    Blockage of glutamine-dependent anaplerosis affects mTORC1/2 activity and ultimately leads to cellular senescence-like response
  12. 1912
    “…Conversely, waist circumference, glucose and triglycerides in isolation were not associated with mortality (p>0.05). CONCLUSION: In a large U.S. population, different combinations of MetS components vary substantially in their associations with all-cause mortality. …”
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    Age- and sex- specific all-cause mortality risk greatest in metabolic syndrome combinations with elevated blood pressure from 7 U.S. cohorts
  13. 1913
    “…Therefore, we evaluated the association of positive affect and CVH in a diverse U.S. population of Hispanics/Latinos with CKD. …”
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    The association of positive affect and cardiovascular health in Hispanics/Latinos with chronic kidney disease: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)
  14. 1914
    “…An early and progressive elevation of urinary SerpinA3 (uSerpinA3) was observed during the AKI to CKD transition together with SerpinA3 relocation from the cytoplasm to the apical tubular membrane in the rat kidney. uSerpinA3/alpha-1-antichymotrypsin was significantly increased in patients with CKD secondary to focal and segmental glomerulosclerosis (FSGS), ANCA associated vasculitis (AAV) and proliferative class III and IV lupus nephritis (LN). uSerpinA3 levels were independently and positively associated with renal fibrosis. …”
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    SerpinA3 in the Early Recognition of Acute Kidney Injury to Chronic Kidney Disease (CKD) transition in the rat and its Potentiality in the Recognition of Patients with CKD
  15. 1915
    “…The methylation of TPSA catalyzed by Rv0560c was subsequently confirmed by LC-MS. Therefore, TPSA as a GlmU acetyltransferase activity inhibitor may offer a structural basis for new anti-tuberculosis drugs. …”
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    The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c
  16. 1916
    “…CLINICALTRIALS.GOV REGISTRY: Name: Obesity and Type 2 Diabetes, Bariatric Surgery Effects on Brain Function URL: https://clinicaltrials.gov/ct2/show/NCT02137070 NCT Identifier: Other Study ID Numbers: 201400034-N 1R01DK099334–01A1 (U.S. NIH Grant/Contract)…”
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    Neurocognitive deficits in a Class II and Class-III obesity cohort: contributions of type-2 diabetes and other comorbidities
  17. 1917
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    Gastric neuroendocrine neoplasias: manifestations and comparative outcomes
  18. 1918
    “…A total of 39 were assigned to injection into the bladder wall of 100 U BTX-A with MB (in 9.5 ml normal saline + 0.5 ml MB), and 41 were assigned to BTX-A 100 U alone (in 10 ml normal saline). Cystoscopy with a submucosal injection of the solution was performed systematically, including the bladder triangle. …”
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    Application of methylene blue as an improvement of the injection technique of botulinum toxin A in the treatment of refractory idiopathic overactive bladder: prospective, single-blind (patient-blind), randomized trial
  19. 1919
    “…Age-stratified analyses showed DBP had no independent effect on stroke admissions among the older patient subgroup (≥60 years of age), but the younger subgroup showed a clear U-shaped relationship. Intensive blood pressure reduction may lead to unintended consequences of higher healthcare utilization because of increased cardiovascular morbidity, and this merits future prospective studies. …”
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    Diastolic Blood Pressure J-Curve Phenomenon in a Tertiary-Care Hypertension Clinic
  20. 1920
    “…The temperature-dependent evolution of Raman active in-plane (3)E(g) phonon, which strongly couples to the polar-active out-of-the-plane A(2u) phonon mode in the high-temperature paraelectric state, exhibits a deviation in Raman shift from the expectation of the pseudospin−phonon model that is widely used to model many insulating FEs. …”
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    Raman interrogation of the ferroelectric phase transition in polar metal LiOsO(3)
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