“…In this issue of EMBO Molecular Medicine, Iwai et al (2018) tackle targeting the splicing regulatory Cdc2‐like kinase (CLKs) family. …”
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“…As conventional antibiotics are running short, the remarkable progress in this field opens up the possibility of tailoring efficient enzybiotics to tackle the most menacing bacterial infections.…”
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“…Our security and performance analyses show that the proposed scheme can tackle the security and efficiency concerns in cloud computing.…”
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“…Tocotrienol, a member of the vitamin E family, can tackle many aspects of AD, such as oxidative stress, mitochondrial dysfunction and abnormal cholesterol synthesis. …”
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“…Since mycobacteriophages target a specific group of bacteria, which include Mycobacterium tuberculosis responsible for one of the leading causes of death worldwide, exploitation of the use of these lytic enzymes demands a special attention, as they may be an alternative to tackle multidrug resistant tuberculosis. This review focuses on the current knowledge of the function of lysis proteins encoded by mycobacteriophages and their potential applications, which may contribute to increasing the effectiveness of antimycobacterial therapy.…”
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“…Recently, several new strategies have emerged to tackle the ‘averaging problem’. In this review, we summarize recent advancements in our ability to characterize neuron-type specific and synapse-type specific proteomes and discuss strengths and limitations of these emerging analysis strategies.…”
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“…One solution that has been proposed to tackle this challenge is to develop a localized protocol on cancer diagnosis disclosure based on the culture and values of community members, and train healthcare team members to deliver the bad news using this protocol. …”
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“…In this Review and accompanying poster, we describe the main mechanisms of immune regulation of metastasis that have been reported to date, and present promising immunotherapeutic options that are currently available, or may become so in the near future, to tackle metastasis.…”
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“…Analytical tools must be endowed with high selectivity, sensitivity, and spatiotemporal resolution to tackle this task. On one hand, in vivo electroanalysis combined with miniature electrodes has evolved into a minimally invasive method for probing transient events during neural communication and metabolism. …”
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“…Despite general success of non-covalent imprinting for a large variety of templates, some groups of compounds remain difficult to tackle due to their structural complexity. In this study we investigate preparation of molecularly imprinted polymers that can bind sulfonamide compounds, which represent important drug candidates. …”
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“…Establishing strong institutions and guidance to tackle abuse when it occurs is both beneficial to the survivors and the continent at large.…”
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“…In this regard, nanoparticle-based systems offer new intriguing possibilities, provided that (i) the harsh and denaturating conditions typically used for nanoparticle synthesis are avoided or mitigated; and (ii) nanoparticle biocompatibility and degradation (for protein release) are optimized. Here, we tackle these issues by starting from a nanoparticle architecture already tested for small chemical compounds. …”
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“…Advances are discussed in depth, where the focus of this review is to tackle mainly solution state anion sensing utilizing quinoxaline‐based receptors using different spectroscopic techniques with reference to anion selectivity by colorimetric and fluorescence response. …”
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“…In this paper, we introduce a horizontally scalable distributed extract-transform-load system to tackle scientific data aggregation, transformation and enhancement for scientific data discovery and retrieval. …”
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“…On the other hand, research on data transmissions in IoT mainly focuses on networking without sufficiently considering the special requirements of the upper-layer applications, such as the data fusion process, that are consuming the transmitted data. In this paper, we tackle the problem of data transmission for data fusion in an IoT environment by proposing a distributed scheduling mechanism VD-CSMA in wireless sensor networks, which considers the values for data fusion, as well as the delay constraints of packets when determining their priority levels for transmission. …”
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“…Due to its epidemic trends among children and adults, there is an increasing interest in implementing new therapeutic interventions to tackle overweight and obesity. Activation of brown adipose tissue (BAT) represents today a promising strategy to enhance energy expenditure (EE) through heat production. …”
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“…This work focused on an approach to tackle the privacy and security issue of multimedia data/information in the internet of things domain. …”
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“…Discovery and development of new therapeutic options for the treatment of Mycobacterium tuberculosis (Mtb) infection are desperately needed to tackle the continuing global burden of this disease and the efficacy and cost limitations associated with current medicines. …”
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“…Further characterization of these host determinants may potentially offer novel insights to develop intervention strategies to tackle ongoing outbreaks.…”
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“…This is aggravated even further by the absence of portable and reliable methods for their determination in the field. A promising way to tackle these issues is the use of enzyme-based and miniaturized biosensors for their electrochemical detection. …”
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