“…Due to the pressures imposed by climate change, the European Union (EU) has been forced to design several initiatives (the Common Agricultural Policy, the European Green Deal, Farm to Fork) to tackle the climate crisis and ensure food security. …”
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“…Recently, growing interest in building predictive models of complexes mediated by Proteolysis Targeting Chimeras (PROTACs) has led to the application of state-of-the-art computational techniques to tackle this problem. However, repurposing existing tools to carry out protein-protein docking and linker conformer generation independently results in extensive sampling of structures incompatible with PROTAC-mediated complex formation. …”
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“…Here we employ the Molecular Transformer, a state-of-the-art model for reaction prediction and single-step retrosynthesis, to tackle this problem. We train the model on the US patents dataset (USPTO) and test it on Reaxys to demonstrate its out-of-distribution generalization capabilities. …”
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“…Among the many tested targets to tackle this virus, its protease enzyme (PR) was proven to be an attractive option that brought about numerous research publications and ten FDA-approved drugs to inhibit the PR activity. …”
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“…Next, we review several methods developed to tackle specific challenges that arise from the characteristics of CMR data. …”
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“…In addition, to better tackle the clinical challenges in endodontics, efforts are needed to improve the bioactivity of bioceramics, particularly to enhance their antimicrobial activity and mechanical properties and reduce their setting time and solubility.…”
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“…In recent years, advances in science and technology have improved our quality of life, enabling us to tackle diseases and increase human life expectancy. …”
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“…These molecules could contribute to the development of new efficient antidiabetic medicines targeting β-cells, which would tackle the progression of the disease.…”
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“…The ubiquitous and widely conserved microbial fatty acid biosynthesis pathway, called FAS-II system, represents a potential target to tackle antimicrobial resistance. This pathway has been extensively studied, and eleven proteins have been described. …”
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“…This article presents a modern approach (builds on two core ideas: abductive thinking and density-sharpening principle) and practical guidelines to tackle these issues in a systematic manner. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10203-023-00390-5.…”
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“…Harnessing the knowledge of iron metabolism may aid in the discovery of new molecular targets and in the development of new drugs that tackle MS and other diseases that share similar pathophysiology.…”
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“…Individualised strategies are needed in lower HDI regions to tackle inequalities.…”
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“…Moreover, MiCrowd addresses the following important challenges: (1) privacy issues, (2) communication costs, and (3) extreme resource constraints on MCUs. To tackle those challenges, we designed a lightweight crowd-counting deep neural network, named MiCrowdNet, which enables on-MCU inferences. …”
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“…The ability to appropriately tackle the problem of resistance requires surveillance from all territories, including resource limited settings. …”
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“…Simultaneously, the synthetic toolbox to tackle the “COF trilemma” has been diversified to include topochemical linkage transformations and post-synthetic stabilization strategies. …”
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“…Various stakeholders' perspectives are also included, providing insight into opportunities and challenges of working with the private sector in this effort. As countries tackle the setbacks brought by COVID-19 and move towards reaching the End TB targets, partnerships such as these can strengthen the foundations of health systems.…”
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“…[Image: see text] Although various spectroscopic methods have been developed to capture ion-concentration profile changes, it is still difficult to visualize the ion-concentration profile and surface topographical changes simultaneously during the charging/discharging of lithium-ion batteries (LIBs). To tackle this issue, we have developed an operando scanning ion conductance microscopy (SICM) method that can directly visualize an ion-concentration profile and surface topography using a SICM nanopipette while controlling the sample potential or current with a potentiostat for characterizing the polarization state during charging/discharging. …”
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“…With years of effort, these three methods compose an expanding vibrational bioimaging toolbox to tackle specific bioimaging needs, benefiting many biological investigations with rich information in both label-free and labeling manners. …”
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“…The channel selection algorithm based on matching as well as the power allocation algorithm based on water injection are developed to tackle the problem. Both theoretical analysis and experimental simulation verify that our method has superior performance in system throughput and spectrum efficiency.…”
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“…Because of acute and chronic undesirable effects frequently associated with conventional cytotoxic chemotherapy, consolidation chemotherapy is not feasible, especially for elderly patients, which has attracted a growing body of research to attempt to tackle this problem. Immunotherapies for acute myeloid leukemia, including immune checkpoint inhibitors, monoclonal antibodies, dendritic cell (DC) vaccines, together with T-cell therapy based on engineered antigen receptor have been developed recently. …”
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