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2901“…DISCUSSION: The present case constitutes an opportunity to revisit percutaneous and non-percutaneous strategies to tackle persistent coronary thrombus showing a contemporary approach to niche technologies such as laser angioplasty.…”
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2902“…That means large companies naturally have certain advantages, but the widely used financial indicators based on total volume or ratio may not reflect the company’s status well because they are also size-dependent. To tackle this problem, this paper proposes a new set of evaluation indices based on the deviations of the macroscopic variables from the scaling law to eliminate the size-dependent effect. …”
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2903“…We also discuss the strategies that can be used to tackle bacterial infections and propose an entente cordiale with the bacterial world so that instead of war and destruction of the ‘fierce enemy’ we can achieve a peaceful coexistence (the One Earth concept) between the human and the bacterial worlds. …”
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2904“…However, the current multiplexed protein imaging technologies suffer from low detection sensitivity, limited multiplexing capacity or technically demanding. To tackle these issues, here we report the development of a highly sensitive and multiplexed in situ protein profiling method using off-the-shelf antibodies. …”
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2905por Lan, Xiaohong, Boetje, Laura, Pelras, Théophile, Ye, Chongnan, Silvianti, Fitrilia, Loos, Katja“…To speed up the bond exchange, significant amounts of catalyst are used, which creates safety concerns. To tackle this issue, we report the synthesis of a lipoic acid-based vitrimer-like elastomer (LAVE) by combining (i) ring-opening polymerization (ROP) of lactones, (ii) lipoic acid modification of polylactones, and (iii) UV crosslinking. …”
Publicado 2023
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2906por Majzoobi, Mahsa, Wang, Ziyu, Teimouri, Shahla, Pematilleke, Nelum, Brennan, Charles Stephen, Farahnaky, Asgar“…This review article aims to collect recent information on developing nutrient-dense grains using a sustainable and natural process known as “sprouting or germination” and to discuss novel applications of sprouted grains to tackle malnutrition (specifically undernutrition). …”
Publicado 2023
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2907“…Conversely, multi-task learning (MTL) can predict multiple ADMET endpoints with fewer labels, but ensuring task synergy and highlighting key molecular substructures remain challenges. To tackle these issues, this work elaborates a multi-task graph learning framework for predicting multiple ADMET properties of drug-like small molecules (MTGL-ADMET) by holding a new paradigm of MTL, “one primary, multiple auxiliaries.” …”
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2908“…These findings have significant policy implications, underscoring the necessity for approaches that simultaneously tackle air pollution and foster financial innovation.…”
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2909“…In conclusion, we recommend that governments employ a targeted approach to tackle tax avoidance in specific enterprises or industries. …”
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2910“…Biofortification, a process of enriching nutrients in staple food crops is an effective method to tackle this malnutrition-associated disorder. Tomato (Solanum lycopersicum) is a globally consumed crop and therefore is a suitable candidate for biofortification. …”
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2911“…However, these therapies encounter multiple challenges in clinical practice, such as high immune-mediated toxicity, insufficient accumulation in cancer tissues, and undesired off-target reactions. To tackle these limitations and enhance bioavailability, polymer micelles present potential solutions by enabling precise drug delivery to the target site, thus amplifying the effectiveness of immunotherapy. …”
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2912por Benito-Gutiérrez, Èlia“…On the evolutionary road to vertebrates, amphioxus occupies a key position to tackle this exciting issue. Its “simple” nervous system basically consists of a dorsal nerve cord and a diffuse net of peripheral neurons, which contrasts greatly with the complexity of vertebrate nervous systems. …”
Publicado 2006
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2913“…Although computational approaches have been proposed for this purpose, there is no integrated and user-friendly software application that allows experimental biologists to tackle this problem in higher eukaryotes. We have previously reported a systematic, statistical model of mammalian transcriptional regulatory sequence analysis. …”
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2914Publicado 1993“…The c-fes protooncogene is expressed at high levels in the terminal stages of granulocytic differentiation, but so far no definite function has been attributed to the product of this oncogene. To tackle this problem, the c-fes protooncogene expression has been inhibited in HL60 cells, and fresh leukemic promyelocytes of acute promyelocytic leukemia have been induced to differentiate with retinoic acid (RA) and dimethylsulfoxide (DMSO). …”
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2915por Fiori, Simone“…Also, statistical modeling is useful when the amount of available data is enough to show relevant statistical features of the phenomenon underlying the data. We propose to tackle the problem of statistical modeling via a neural (nonlinear) system that is able to match its input-output statistic to the statistic of the available data sets. …”
Publicado 2007
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2916“…Images provided by conventional direct reconstruction methods usually bear ringing, streaking, and other leakage artifacts caused by discontinuous structures. In this paper, we tackle these problems by analyzing the principal point spread function (PSF) of non-Cartesian reconstruction and propose a leakage reduction reconstruction scheme based on discontinuity subtraction. …”
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2917“…This is in direct conflict with offers by the company to contribute to stronger international cooperation to tackle the illicit tobacco trade.…”
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2918por Brauer, S“…In Just health, Norman Daniels argues that under certain circumstances age rationing is prudent, and therefore a morally permissible strategy to tackle the problem of resource scarcity. Crucial to his argument is the distinction between two problem-settings of intergenerational equity: equity among age groups and equity among birth cohorts. …”
Publicado 2009
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2919por Xu, Yong, Jones, Juli E., Kohno, Daisuke, Williams, Kevin W., Lee, Charlotte E., Choi, Michelle J., Anderson, Jason G., Heisler, Lora K., Zigman, Jeffrey M., Lowell, Bradford B., Elmquist, Joel K.“…Drugs activating 5-hydroxytryptamine 2C receptors (5-HT(2C)Rs) potently suppress appetite, but the underlying mechanisms for these effects are not fully understood. To tackle this issue, we generated mice with global 5-HT(2C)R deficiency (2C null) and mice with 5-HT(2C)Rs re-expression only in pro-opiomelanocortin (POMC) neurons (2C/POMC mice). …”
Publicado 2008
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2920“…A number of solutions have been proposed. To tackle systemic barriers to healthcare provision integrated care models could be employed including co-location of physical and mental health services or the use of case managers or other staff to undertake a co-ordination or liaison role between services. …”
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