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  1. 3081
    “…Cardiac surgeons must bear in mind that this is a real problem that we must tackle. The purpose of this paper is to be a wake-up call to the surgical community by giving a brief overview of what PPM is, its incidence and impact on the outcomes. …”
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  2. 3082
    por Davey Smith, George
    Publicado 2019
    “…In the last third of the 20th century, etiological epidemiology within academia in high-income countries shifted its primary concern from attempting to tackle the apparent epidemic of noncommunicable diseases to an increasing focus on developing statistical and causal inference methodologies. …”
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  3. 3083
    “…Thus, there is an urgent need to find novel strategies in order to tackle this vital medical issue. One of the most pivotal causes of cancer initiation is the presence of reactive oxygen species (ROS) inside the body. …”
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  4. 3084
    por Ma, Xiaoshuang, Wu, Penghai
    Publicado 2019
    “…The proposed filtering framework consists of four main steps: (1) a prefiltering result of each image is obtained by a nonlocal weighted average using only the information of the corresponding time phase; (2) an adaptively temporal linear filter is employed to further suppress the speckle; (3) the final output of each patch is obtained by a guided filter using both the original speckled data and the filtering result of step 3; and (4) an aggregation step is used to tackle the multiple estimations problem for each pixel. …”
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  5. 3085
    “…We draw attention to the shortcomings in m/paternity leave rights in the EP and the lack of political will within the party groups to tackle this, which is further cementing exclusionary practices of the institution.…”
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  6. 3086
    “…Cellular therapy is enabling new approaches to tackle significant unmet needs in areas such as regenerative medicine and immunotherapy. …”
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  7. 3087
    “…The Government of Nepal (GoN) has taken some initiatives to tackle burgeoning problems such as antimicrobial resistance, highly pathogenic avian influenza and rabies using OH approach but there are several challenges at the level of implementation. …”
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  8. 3088
    “…In this review, we will tackle the existing evidence and caveats advocating for and against the target-derived NTF deprivation theory in glaucoma, whilst digging into associated therapy efforts.…”
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  9. 3089
    “…Numerous solutions have been proposed to tackle the problem of precise control of sensor(s) for multi-object detection and tracking, and, in this work, recent contributions towards the advancement in the domain are comprehensively reviewed. …”
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  10. 3090
    “…We focus on the time-varying nature of the Jensen performance measure α and the market systematic risk sensitivity β, as these parameters are essentially universal in asset pricing models. To tackle endogeneity and other specification errors, we rely on our robust instrumental variables (RIV) algorithm implemented via a GMM approach. …”
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  11. 3091
    “…In this paper, we investigate and analyze recent literature related to the use of blockchains to tackle issues found in modern healthcare information systems. …”
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  12. 3092
    “…Although many works aim to tackle the problem of facial expression recognition, and the discriminative power may be acceptable, current solutions have limited explicative power, which is insufficient for certain applications, such as facial rehabilitation. …”
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  13. 3093
    por Zhu, Xuan, Chen, Lijie, Liu, Ling, Niu, Xing
    Publicado 2019
    “…Progress in delineating the nature of this process offers an opportunity to develop clinical therapeutics to tackle resistance toward anticancer agents. Herein, we seek to provide a framework for the mechanistic underpinnings on the EMT-mediated acquisition of EGFR-TKI resistance, with a focus on NSCLC, and raise the question of what therapeutic strategies along this line should be pursued to optimize the efficacy in clinical practice.…”
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  14. 3094
    “…We conclude the review with some recommendations for ways future research can tackle these challenges to move the field forward.…”
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  15. 3095
    “…The respiratory chain has been proposed as an attractive target for the development of new therapies to tackle human fungal pathogens. This arises from the presence of fungal-specific electron transport chain components and links between respiration and the control of virulence traits in several pathogenic species. …”
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  16. 3096
    “…Vitamin E compounds, including different types of tocopherols and tocotrienols, have been considered as a treatment to tackle major cardiovascular outcomes in diabetic subjects, but often with conflicting or even negative results. …”
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  17. 3097
    “…As a pilot study, the CSMP utilizes a mixed-methods design to tackle a lack of previous evidence and form a well-rounded perspective, using a randomized controlled trial with pre, post and 3-month follow-up assessments and focus group discussions. …”
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  18. 3098
    “…In the present work, an easily implementable method is introduced to effectively tackle these drawbacks. Instead of fitting the drop-profile itself, the polynomial fitting is applied to the difference between the drop profile and the circumcircle, independently for both sides of the drop. …”
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  19. 3099
    por Orellana, Laura
    Publicado 2019
    “…Here we briefly survey current in silico methods to tackle large conformational changes, reviewing recent examples of cross-validation of experiments and computational predictions, which show how the integration of different scale simulations with biological information is already starting to break the barriers between the in silico, in vitro, and in vivo worlds, shedding new light onto complex biological problems inaccessible so far.…”
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  20. 3100
    por Hernández, Isaac, Vecchi, Davide
    Publicado 2019
    “…Our main research question is to tackle the foundational problem posed by the dynamics of biotic entrenchment characterising multi-species partnerships for the closure of constraints interpretation, namely, to understand for which biological system (i.e., the partners taken individually or the partnership as the encompassing system) closure of constraints is realised. …”
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