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  1. 3761
    por Makrilakis, Konstantinos
    Publicado 2019
    “…Due to its multi-factorial pathophysiology, its treatment is varied and based upon a multitude of pharmacologic agents aiming to tackle the many aspects of the disease pathophysiology (increasing insulin availability [either through direct insulin administration or through agents that promote insulin secretion], improving sensitivity to insulin, delaying the delivery and absorption of carbohydrates from the gastrointestinal tract, or increasing urinary glucose excretion). …”
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    The Role of DPP-4 Inhibitors in the Treatment Algorithm of Type 2 Diabetes Mellitus: When to Select, What to Expect
  2. 3762
    “…In this work, we propose a fully-convolutional Siamese architecture to tackle this task, achieving state-of-the-art results on three publicly-released datasets, namely Pandora, High-Resolution Range-based Face Database (HRRFaceD), and CurtinFaces. …”
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    Driver Face Verification with Depth Maps
  3. 3763
    “…Such a novel animal model would facilitate the understanding of the complex interplay of different mechanisms that are common to obesity and ageing and help to devise strategies in future to tackle the growing burden of obesity and ageing.…”
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    ‘Obesageing’: Linking obesity & ageing
  4. 3764
    por Al-Musawi, Safa, Houbby, Nour
    Publicado 2019
    “…Offering entrepreneurship teaching in medical schools will not only diversify the skills of future health care professionals, but will also empower them with the right mindset to tackle the problems facing the health care system and sustain the NHS.…”
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    Addressing the void of entrepreneurship development amongst medical students in the UK
  5. 3765
    “…On this basis, we formulate the bandwidth-constrained traffic sensing (BCTS) problem, aiming at minimizing the estimation error based on the collected traffic data. To tackle the BCTS problem, we first propose the bandwidth-aware data collection (BDC) algorithm to select the optimal uploaded traffic data by evaluating the priority of each road segment covered by the MEC server. …”
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    Bandwidth-Aware Traffic Sensing in Vehicular Networks with Mobile Edge Computing
  6. 3766
    “…Real-time MRI-guided systems have been used to perform electroanatomic mapping and ablation in patients with atrial flutter, and there is interest in developing the technology to tackle more complex arrhythmias including atrial fibrillation and ventricular tachycardia. …”
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    Advances in Real-Time MRI–Guided Electrophysiology
  7. 3767
    “…Conventional geophones have problems such as a narrow spectral width, low sensitivity, and poor coupling with the tunnel wall. To tackle issues above, we propose a semi-automatic coupling geophone equipped with a piezoelectric sensor with a spectral range of 10–5000 Hz and a sensitivity of 2.8 V/g. …”
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    A Semi-Automatic Coupling Geophone for Tunnel Seismic Detection
  8. 3768
    “…The impact, however, of the drug-target residence time on in vivo efficacy remains controversial due to difficulties in experimentally determining the in vivo target occupancy during drug treatment. To tackle this problem, an in vivo displacement assay was developed using soluble epoxide hydrolase as a biological model. …”
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    Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways
  9. 3769
    “…Here we discuss this missed opportunity to encourage engagement and skill development of young scientists, and provide a case study of a student centric science journal aimed to tackle these challenges.…”
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    Extending the science fair project beyond the walls of the gymnasium with the Canadian Science Fair Journal
  10. 3770
    “…Current medical and surgical treatments are only supportive and poorly tackle the underlying problem of corneal anesthesia; hence, fail to provide a permanent cure. …”
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    Update On Cenegermin Eye Drops In The Treatment Of Neurotrophic Keratitis
  11. 3771
    “…The MS-CRMRC offers an accessible alternative to empower the research enterprise by developing knowledgeable skilled professionals to tackle this need.…”
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    2419: Clinical research management and regulatory compliance: A graduate distance learning model
  12. 3772
    “…The crucial problems of underwater swarm monitoring are communication and behavior coordination. To tackle these problems, we propose a wide area monitoring strategy that searches for static targets of interest simultaneously. …”
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    A Pheromone-Inspired Monitoring Strategy Using a Swarm of Underwater Robots
  13. 3773
    “…One of the strategies to tackle these infections is to replace the main vector agent, Ae. aegypti, with the ones incapable of transmitting the virus. …”
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    Mathematical analysis of a Wolbachia invasive model with imperfect maternal transmission and loss of Wolbachia infection
  14. 3774
    “…Major obstacles arise when short RNA sequences map to multiple locations in the genome, align to regions that are not annotated or underwent post-transcriptional changes which hamper accurate mapping. In order to tackle these issues, we present a novel profiling strategy that circumvents the need for read mapping to a reference genome by utilizing the actual read sequences to determine expression intensities. …”
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    DEUS: an R package for accurate small RNA profiling based on differential expression of unique sequences
  15. 3775
    “…While managing hepatitis C, we recommend a multidisciplinary approach to tackle cutaneous and other extrahepatic manifestations.…”
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    The Frequency of Cutaneous Manifestations in Hepatitis C: A Cross-sectional Study in a Tertiary Care Hospital in Pakistan
  16. 3776
    “…Quantification of health effects attributable to air pollution (PM(2.5)) is important in policy implications to tackle air pollution and associated health problems. …”
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    Nexus between Air Pollution and Neonatal Deaths: A Case of Asian Countries
  17. 3777
    “…Specific challenges identified were: Scope of adaptations modelled, Information on future adaptation, Collaboration to tackle novel challenges, Optimisation under progressive change with thresholds, and Responsibility given the sensitivity of future outcomes to initial choices under progressive change.…”
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    To what extent is climate change adaptation a novel challenge for agricultural modellers?
  18. 3778
    “…Drug screening models have a vital role in the development of novel antimycobacterial agents which are urgently needed to tackle drug-resistant tuberculosis (TB). We recently established the larvae of the insect Galleria mellonella (greater wax moth) as a novel infection model for the Mycobacterium tuberculosis complex. …”
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    Galleria mellonella: An Infection Model for Screening Compounds Against the Mycobacterium tuberculosis Complex
  19. 3779
    “…We consider the nontrivial problem of estimating the health cost repartition among different diseases in the common case where the patients may have multiple diseases. To tackle this problem, we propose to use an iterative proportional repartition (IPR) algorithm, a nonparametric method which is simple to understand and to implement, allowing (among other) to avoid negative cost estimates and to retrieve the total health cost by summing up the estimated costs of the different diseases. …”
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    Estimating Health Cost Repartition Among Diseases in the Presence of Multimorbidity
  20. 3780
    “…Then, to deal with nonlinear data in real scenarios, the‘kernelized version is also proposed. Moreover, to tackle the gross corruptions mixed in the query set, the proposed model is extended for robust ISM. …”
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    Exploring Inter-Instance Relationships within the Query Set for Robust Image Set Matching
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