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  1. 13201
    “…Collectively, our results reveal why non-cleavage site mutations have far-reaching implications outside of Gag proteolysis, with important consequences for drugging Gag maturation intermediates and tackling protease inhibitor resistance.…”
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    The impact of Gag non-cleavage site mutations on HIV-1 viral fitness from integrative modelling and simulations
  2. 13202
    “…This paper provides an overview of the therapeutic option for BCBM that is currently available and outlines potential new approaches for tackling these deadly secondary tumours.…”
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    Treatment strategies for breast cancer brain metastases
  3. 13203
    “…This commentary spells out the complexity of issues that need to be tackled to design and implement food systems that improve diets, nutrition, and health in an equitable fashion, while simultaneously respecting planetary boundaries. …”
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    Transforming Food Systems: The Missing Pieces Needed to Make Them Work
  4. 13204
    “…Managed forests are a key component of strategies aimed at tackling the climate and biodiversity crises. Tapping this potential requires a better understanding of the complex, simultaneous effects of forest management on biodiversity, carbon stocks and productivity. …”
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    Biodiversity response to forest management intensity, carbon stocks and net primary production in temperate montane forests
  5. 13205
    “…Such an understanding will provide significant benefits for tackling the ubiquitous problem of biofilm contamination in food, water and medical areas.…”
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    Interactions of plasma-activated water with biofilms: inactivation, dispersal effects and mechanisms of action
  6. 13206
    “…There are a varying number of challenges encountered during developing the most effective vaccines, and measures for tackling such challenges will assist in fast pace development of vaccines. …”
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    Targets and strategies for vaccine development against SARS-CoV-2
  7. 13207
    por Li, Hao, Sun, Jianwu
    Publicado 2021
    “…The unique electronic structure of 3C-SiC tackles the challenge associated with low selectivity of photocatalytic CO(2) reduction to C(1) compounds. …”
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    Highly Selective Photocatalytic CO(2) Reduction to CH(4) by Ball-Milled Cubic Silicon Carbide Nanoparticles under Visible-Light Irradiation
  8. 13208
    “…SUMMARY: SVD is the leading cause of VCI and is associated with substantial morbidity. Tackling cardiovascular risk factors is currently the most effective approach to prevent cognitive decline in the elderly. …”
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    Cerebral small vessel disease and vascular cognitive impairment: from diagnosis to management
  9. 13209
    por Wang, Yensheng, Kong, Yifei, Wu, Mei X.
    Publicado 2021
    “…This unpleasant and sometimes fatal allergic disease has been tackled vigorously by allergen-specific immunotherapy over a century, but the progress made so far is far from satisfactory for some allergies. …”
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    Innovative Systems to Deliver Allergen Powder for Epicutaneous Immunotherapy
  10. 13210
    por Lewis, Armanda, Stoyanovich, Julia
    Publicado 2021
    “…In this paper we recount a recent experience in developing and teaching a technical course focused on responsible data science, which tackles the issues of ethics in AI, legal compliance, data quality, algorithmic fairness and diversity, transparency of data and algorithms, privacy, and data protection. …”
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    Teaching Responsible Data Science: Charting New Pedagogical Territory
  11. 13211
    “…Nevertheless, the degradation rate and hydrogen release of MBIs in the body have to be tackled for practical applications. In the present study, we present a metal–organic framework (MOF) nanoplates to reduce the degradation rate of AZ91 magnesium alloy. …”
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    Controlled biodegradation of magnesium alloy in physiological environment by metal organic framework nanocomposite coatings
  12. 13212
    “…The highly nonlinear system is tackled numerically is addressed by the bvp4c built-in function of the MATLAB procedure. …”
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    Nonlinear radiative Maxwell nanofluid flow in a Darcy–Forchheimer permeable media over a stretching cylinder with chemical reaction and bioconvection
  13. 13213
    “…These evidences highlight the importance of ensuring that glycans are considered when tackling this disease, particularly in the development of vaccines, therapeutic strategies and serological testing.…”
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    Glycosylation is a key in SARS-CoV-2 infection
  14. 13214
    “…Homonuclear correlations, however, are of limited spectral resolution, and usually incapable of tackling relatively large homopolymers with repeating structures like RNAs. …”
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    3D Heteronuclear Magnetization Transfers for the Establishment of Secondary Structures in SARS-CoV-2-Derived RNAs
  15. 13215
    “…Reflecting on the reciprocal relationships between multiple domains, levels of scale and related social contextual factors known to impact on wellbeing, our GENIAL framework may provide a foundation for a transdisciplinary science of wellbeing that has the potential to promote the wellbeing of individuals while also playing a key role in tackling major societal challenges.…”
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    Moving Beyond Disciplinary Silos Towards a Transdisciplinary Model of Wellbeing: An Invited Review
  16. 13216
    “…Challenges remain to be tackled, among them institutionalization and quality of results. …”
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    Cuentas de salud del pasado al presente para una aritmética política()
  17. 13217
    “…Concerns with AMR have resulted in multiple initiatives internationally, nationally and regionally to enhance appropriate antibiotic utilization across sectors to reduce AMR, with the overuse of antibiotics exacerbated by the COVID-19 pandemic. Effectively tackling AMR is crucial for all countries. Principally a narrative review of ongoing activities across sectors was undertaken to improve antimicrobial use and address issues with vaccines including COVID-19. …”
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    Strategies to Improve Antimicrobial Utilization with a Special Focus on Developing Countries
  18. 13218
    “…The effect of mask‐wearing on face recognition in a collaborative environment is currently a sensitive yet understudied issue. Recent reports have tackled this by using face images with synthetic mask‐like face occlusions without exclusively assessing how representative they are of real face masks. …”
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    Extended evaluation of the effect of real and simulated masks on face recognition performance
  19. 13219
    “…Since the identification of the first COVID-19 cases in November 2019, the World Health Organization (WHO) has played a crucial role in tackling the country-level pandemic preparedness and patient management protocols. …”
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    SARS-CoV-2 Viral Shedding and Transmission Dynamics: Implications of WHO COVID-19 Discharge Guidelines
  20. 13220
    “…The present review summarizes some of the most promising developments in this field and discusses issues that need to be considered for the effective translation of this knowledge to improve therapies for tackling snakebite envenoming.…”
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    The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming
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