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13501por Kaufmann, Kristian W., Lemmon, Gordon H., DeLuca, Samuel L., Sheehan, Jonathan H., Meiler, Jens“…We provide a brief review of the six most frequent research problems tackled with Rosetta. For each of these six tasks, we provide a tutorial that illustrates a basic Rosetta protocol. …”
Publicado 2010
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13502por Chen, Bin, Dong, Xiao, Jiao, Dazhi, Wang, Huijun, Zhu, Qian, Ding, Ying, Wild, David J“…Initiatives such as Bio2RDF and LODD have tackled the problem of linking biological data and drug data respectively using RDF. …”
Publicado 2010
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13503por Cappallo-Obermann, Heike, von Kopylow, Kathrein, Schulze, Wolfgang, Spiess, Andrej-Nikolai“…We investigated this question by microarray analysis in which we had to eliminate the ‘germ cell effect’, i.e., the dominating effect of germ cell transcripts due to the quantitative difference in germ cell composition in samples with/without YCMD. This problem was tackled by selecting 26 samples from an initial cohort of 34 samples by their homogeneity in respect to cellular composition as obtained from gene expression clustering. …”
Publicado 2010
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13504por Tavassoli, Ali Akbar, Gharipour, Mojgan, Khosravi, Alireza, Kelishadi, Roya, Siadat, Zahra Dana, Bahonar, Ahmad, Sadri, Gholam Hosein, Sadeghi, Masoumeh, Rabiei, Katayoun, Sajjadi, Firouzeh, Zarfeshani, Sonia, Eshrati, Babak, Shirani, Shahin, Sarrafzadegan, Nizal“…Such gender differences should be considered for culturally-appropriate interventional strategies to be implemented at the population level for tackling obesity and associated cardiometabolic risk factors.…”
Publicado 2010
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13505“…Furthermore, with the rapid expansion of the indications for minimal access surgery in emergency situations, these rare emergencies are increasingly tackled using a laparoscopic approach leading to swift patient recovery and discharge. …”
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13506por Allender, Steven, Nichols, Melanie, Foulkes, Chad, Reynolds, Rebecca, Waters, Elizabeth, King, Lesley, Gill, Tim, Armstrong, Rebecca, Swinburn, Boyd“…The core aims of the CO-OPS Collaboration are to: identify and analyse the lessons learned from a range of community-based initiatives aimed at tackling obesity, and; to identify the elements that make community-based obesity prevention initiatives successful and share the knowledge gained with other communities. …”
Publicado 2011
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13507“…It is thus a key issue for interpreting short and long term evolutionary patterns to identify whether main directions of phenotypic variance indeed constitute direction of facilitated evolution, and whether this is favored by developmental processes preferably generating certain phenotypes. We tackled these questions by a morphometric quantification of the directions of variance, compared to the direction of evolution of the first upper and lower molars of wild continental and insular house mice. …”
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13508por Molyneux, David, Hallaj, Zuhair, Keusch, Gerald T, McManus, Donald P, Ngowi, Helena, Cleaveland, Sarah, Ramos-Jimenez, Pilar, Gotuzzo, Eduardo, Kar, Kamal, Sanchez, Ana, Garba, Amadou, Carabin, Helene, Bassili, Amal, Chaignat, Claire L, Meslin, Francois-Xavier, Abushama, Hind M, Willingham, Arve L, Kioy, Deborah“…This implementation deficit is attributable to several factors but one often overlooked is the specific difficulty in tackling diseases that involve both people and animals - the zoonoses. …”
Publicado 2011
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13509por Nguyen, Quang Ngoc, Pham, Son Thai, Do, Loi Doan, Nguyen, Viet Lan, Wall, Stig, Weinehall, Lars, Bonita, Ruth, Byass, Peter“…Multiple CVDRFs were common in Vietnamese adults with different clustering patterns across sex/age groups. Tackling any single risk factor would not be efficient.…”
Publicado 2012
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13510por Jang, Hyeongap, Lim, Jun-Tae, Oh, Juhwan, Lee, Seon-Young, Kim, Yong-Ik, Lee, Jin-Seok“…CONCLUSIONS: The result of the multi-level analysis for the regional variables suggests that social distance for mental illness are not only determined by individual factors but also influenced by the surroundings so that it could be tackled sufficiently with appropriate considering of the relevant regional context with individual characteristics.…”
Publicado 2012
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13511“…There is therefore raising interest in nutrition research to characterize the molecular foundations of the gut microbial–mammalian cross talk at both physiological and biochemical pathway levels. Tackling these challenges can be achieved through systems biology approaches, such as metabolomics, to underpin the highly complex metabolic exchanges between diverse biological compartments, including organs, systemic biofluids, and microbial symbionts. …”
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13512“…Important epidemiological descriptions have informed us on the causes and distribution of NCDs and their risk factors, including the non-health determinants (poverty, education, employment, etc) and health systems assessments, have shown the inadequacies in tackling NCDs. Several global efforts and publications have provided guidance in shaping the research agenda. …”
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13513“…CONCLUSIONS: The manuscript discusses the basic usage issues and other barriers which are to be tackled before technology-based approaches to mental care can be successfully rolled out and their true value appraised.…”
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13514por Ernst, Alexandra, Botzung, Anne, Gounot, Daniel, Sellal, François, Blanc, Frédéric, de Seze, Jerome, Manning, Liliann“…This preliminary study tackles the assessment and treatment of autobiographical memory (AbM) in relapsing-remitting multiple sclerosis (RR-MS) patients. …”
Publicado 2012
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13515por Mracek, Philipp, Santoriello, Cristina, Idda, M. Laura, Pagano, Cristina, Ben-Moshe, Zohar, Gothilf, Yoav, Vallone, Daniela, Foulkes, Nicholas S.“…However, is the combined regulation by E- and D-boxes a general feature for all light-induced gene expression? We have tackled this question by examining the regulation of additional light-inducible genes. …”
Publicado 2012
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13516por Walzer, Chris, Kowalczyk, Christine, Alexander, Jake M., Baur, Bruno, Bogliani, Giuseppe, Brun, Jean-Jacques, Füreder, Leopold, Guth, Marie-Odile, Haller, Ruedi, Holderegger, Rolf, Kohler, Yann, Kueffer, Christoph, Righetti, Antonio, Spaar, Reto, Sutherland, William J., Ullrich-Schneider, Aurelia, Vanpeene-Bruhier, Sylvie N., Scheurer, Thomas“…We suggest new approaches in tackling the issue of an ecological continuum in the Alps by analysing and classifying the characteristics of the resulting questions in a non-prioritized form as well as in a visual conceptualisation of the inter-dependencies among these questions. …”
Publicado 2013
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13517“…These concerns may be tackled with the development of HIV-2 vaccine as a natural control of HIV-1 that has been found in ancestors of HIV-2 i.e. …”
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13518por Korjonen, Helena“…OBJECTIVES: Develop a website, the OLC, which supports those people who work on promoting a healthy weight and tackling obesity. Research shows that original networks where sharing of information and peer interaction take place create solutions to current public health challenges. …”
Publicado 2011
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13519“…Although a number of studies have tackled the problem, no analysis has definitively explained the reason for this trend. …”
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13520“…In particular, interrogating the context-dependent variability of FOXO-interaction networks could predict the clinical potential of cellular-stress response genes and aging regulators for tackling brain and peripheral pathology in neurodegenerative disease. …”
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