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  1. 15761
    “…BACKGROUND: Diagnostics of the human ageing process may help predict future healthcare needs or guide preventative measures for tackling diseases of older age. We take a transcriptomics approach to build the first reproducible multi-tissue RNA expression signature by gene-chip profiling tissue from sedentary normal subjects who reached 65 years of age in good health. …”
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    A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
  2. 15762
    “…CONCLUSIONS: Notch inhibitors may have potential in sensitizing breast cancer cells to chemotherapeutics and therefore in tackling chemoresistance. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12885-015-1625-y) contains supplementary material, which is available to authorized users.…”
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    Chemotherapy induces Notch1-dependent MRP1 up-regulation, inhibition of which sensitizes breast cancer cells to chemotherapy
  3. 15763
    “…If effective, the proposed intervention would provide both researchers and practitioners in this field with a platform on which to develop similar intervention programmes for tackling the repercussions of an unhealthy lifestyle. …”
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    Metabolic risk management, physical exercise and lifestyle counselling in low-active adults: controlled randomized trial (BELLUGAT)
  4. 15764
    “…CONCLUSIONS: Excess BMI is associated with substantially shorter healthy and chronic disease-free life expectancy, suggesting that tackling obesity would increase years lived in good health in populations.…”
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    Body mass index as a predictor of healthy and disease-free life expectancy between ages 50 and 75: a multicohort study
  5. 15765
    “…Moreover, elucidating biological mechanisms driving the induced disease resistance and influencing these observable disease phenotypes has never been systematically tackled, eliciting the need for an efficient model to characterize completely the gene target under consideration. …”
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    A post-gene silencing bioinformatics protocol for plant-defence gene validation and underlying process identification: case study of the Arabidopsis thaliana NPR1
  6. 15766
    “…Furthermore, mild-to-moderate depression-specific factors need to be tackled in any physical activity initiative, via psychological treatments such as Cognitive Behavioural Therapy. …”
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    A scoping study of interventions to increase the uptake of physical activity (PA) amongst individuals with mild-to-moderate depression (MMD)
  7. 15767
    “…Finally, a ready-to-use evaluation framework to deploy in Studies Within A Trial as well as an explanatory retention framework will be developed for identifying and tackling modifiable issues to improve trial retention. …”
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    Systematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol
  8. 15768
    “…In addition, the findings demonstrated the intricate and complex relations between the elements, which further affirms the need for a systems thinking approach to tackling health systems challenges.…”
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    Elements for harnessing participatory action research to strengthen health managers’ capacity: a critical interpretative synthesis
  9. 15769
    “…Phytoremediation involving the synergism of legume and rhizobia provides a useful technique in tackling this issue with cost-effective, environmentally friendly, and easy-to-use features under adverse soil conditions. …”
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    Inoculation of Sinorhizobium saheli YH1 Leads to Reduced Metal Uptake for Leucaena leucocephala Grown in Mine Tailings and Metal-Polluted Soils
  10. 15770
    “…CONCLUSION: The European Youth Tackling Obesity-Kids, SM and peer-led intervention, effectively increased physical activity hours/week in girls, but was not effective in improving the percentage of children who consumed the recommended fruit. …”
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    Impact of a youth-led social marketing intervention run by adolescents to encourage healthy lifestyles among younger school peers (EYTO-Kids project): a parallel-cluster randomised controlled pilot study
  11. 15771
    “…This work also suggests that tackling EV molecular alterations secreted into interstitial fluids can provide an alternative, non-invasive approach for investigating 3D tissue behaviors at the molecular precision. …”
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    3D cell culture stimulates the secretion of in vivo like extracellular vesicles
  12. 15772
    “…BACKGROUND: Over-testing of patients is a significant problem in clinical medicine that can be tackled by education. Clinical reasoning learning (CRL) is a potentially relevant method for teaching test ordering and interpretation. …”
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    Interactive whiteboard use in clinical reasoning sessions to teach diagnostic test ordering and interpretation to undergraduate medical students
  13. 15773
    “…Therefore, the prior focus might be raising awareness among parents concerning overweight in children aged 4 to 12 years and, thereby, stressing the potential supporting role of primary care professionals in tackling the overweight of their child.…”
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    Discussing overweight in children during a regular consultation in general practice: a qualitative study
  14. 15774
    “…Deep learning (DL) has been shown to be effective in developing diabetic retinopathy (DR) algorithms, possibly tackling financial and manpower challenges hindering implementation of DR screening. …”
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    Technical and imaging factors influencing performance of deep learning systems for diabetic retinopathy
  15. 15775
    “…CHWs perceived a high burden of ear and hearing disorders in their community and recognised the role they could play in tackling that burden. Potential barriers identified included a lack of equipment, training, and supervision of CHWs; logistical, financial, or psychological barriers to community participation; and the widespread use of traditional medicine. …”
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    Exploring perceptions, barriers, and enablers for delivery of primary ear and hearing care by community health workers: a photovoice study in Mukono District, Uganda
  16. 15776
    “…Many HIV clinics share staff and logistics with infectious disease facilities, which are now on the frontline in tackling COVID-19. Therefore, this study investigated the impact of the current pandemic situation on HIV care and continuity of antiretroviral treatment (ART) supplies in CEE countries. …”
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    HIV care in times of the COVID-19 crisis — Where are we now in Central and Eastern Europe?
  17. 15777
    “…Perceived barriers to MHPSS programme implementation were consistent with the previous studies and need to be tackled with a structured plan of action.…”
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    Assessment of the knowledge, attitudes, and practices (KAP) among UNRWA* health staff in Jordan concerning mental health programme pre-implementation: a cross-sectional study
  18. 15778
    “…The project underscores the efficiency of this rapid diagnostic assay in tackling several challenges in pediatric TB diagnosis, identifies opportunities for further interventions as well as brings to light scope for effective engagement with healthcare providers. …”
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    Upfront Xpert MTB/RIF for diagnosis of pediatric TB—Does it work? Experience from India
  19. 15779
    “…Understanding the prescribing pattern of antibiotics is crucial to tackling irrational prescription. Yet, comprehensive studies regarding the prescribing pattern of antibiotics among inpatients and the need for an Antibiotic Stewardship Program (ASP) are lacking in Ethiopia. …”
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    Prescribing Pattern of Antibiotics Using WHO Prescribing Indicators Among Inpatients in Ethiopia: A Need for Antibiotic Stewardship Program
  20. 15780
    “…These shortcomings and challenges were tackled by seeking support from peers and senior medical students as a way of coping with the anxiety and stress. …”
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    Perceptions and processes influencing the transition of medical students from pre-clinical to clinical training
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