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  1. 73181
    “…Accordingly, the aim of this article is to review the current state of the art of leptin in relation to AN to provide the theoretical basis for the initiation of clinical trials for treatment of this eating disorder.…”
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    Clinical Trials Required to Assess Potential Benefits and Side Effects of Treatment of Patients With Anorexia Nervosa With Recombinant Human Leptin
  2. 73182
    “…METHODS: We used WES data from the 1000 Genomes project to evaluate the impact of various methods of reference sample set selection on CNV calling performance of three chosen state-of-the-art tools: CODEX, CNVkit and exomeCopy. Two naive solutions (all samples as reference set and random selection) as well as two clustering methods (k-means and k nearest neighbours (kNN) with a variable number of clusters or group sizes) have been evaluated to discover the best performing sample selection method. …”
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    Comparison of kNN and k-means optimization methods of reference set selection for improved CNV callers performance
  3. 73183
    “…METHODS: We implemented community-based cross-sectional study on self-collection HR-HPV screening in conjunction with existing community outreach models for the distribution of antiretroviral therapy (ART) and the World Health Organization Expanded Program on Immunization (EPI) outreach in villages in rural Zimbabwe from January 2017 through May 2017. …”
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    Community-based self-collected human papillomavirus screening in rural Zimbabwe
  4. 73184
    “…This results in our method returning more bona fide regulatory modules than other state-of-the art approaches for clustering on graphs. CONCLUSIONS: Interestingly, we find that lncRNA network hubs tend to be significantly enriched in evolutionary conserved lncRNAs and enhancer-like functions. …”
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    Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis
  5. 73185
    por ZANOLETTI, E., MAZZONI, A., MARTINI, A., ABBRITTI, R.V., ALBERTINI, R., ALEXANDRE, E., BARO, V., BARTOLINI, S., BERNARDESCHI, D., BIVONA, R., BONALI, M., BORGHESI, I., BORSETTO, D., BOVO, R., BREUN, M., CALBUCCI, F., CARLSON, M.L., CARUSO, A., CAYÉ-THOMASEN, P., CAZZADOR, D., CHAMPAGNE, P.-O., COLANGELI, R., CONTE, G., D’AVELLA, D., DANESI, G., DEANTONIO, L., DENARO, L., DI BERARDINO, F., DRAGHI, R., EBNER, F.H., FAVARETTO, N., FERRI, G., FIORAVANTI, A., FROELICH, S., GIANNUZZI, A., GIRASOLI, L., GROSSARDT, B.R., GUIDI, M., HAGEN, R., HANAKITA, S., HARDY, D.G., IGLESIAS, V.C., JEFFERIES, S., JIA, H., KALAMARIDES, M., KANAAN, I.N., KRENGLI, M., LANDI, A., LAUDA, L., LEPERA, D., LIEBER, S., LLOYD, S.L.K., LOVATO, A., MACCARRONE, F., MACFARLANE, R., MAGNAN, J., MAGNONI, L., MARCHIONI, D., MARINELLI, J.P., MARIONI, G., MASTRONARDI, V., MATTHIES, C., MOFFAT, D.A., MUNARI, S., NARDONE, M., PARESCHI, R., PAVONE, C., PICCIRILLO, E., PIRAS, G., PRESUTTI, L., RESTIVO, G., REZNITSKY, M., ROCA, E., RUSSO, A., SANNA, M., SARTORI, L., SCHEICH, M., SHEHATA-DIELER, W., SOLOPERTO, D., SORRENTINO, F., STERKERS, O., TAIBAH, A., TATAGIBA, M., TEALDO, G., VLAD, D., WU, H., ZANETTI, D.
    Publicado 2019
    “…The aim of this work was attempting to report the state of the art of the lateral skull base surgery after 50 years of hard work and, above all, to raise questions on those issues which still need an answer, as to allow progress in knowledge through sharing of various experiences. …”
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    Surgery of the lateral skull base: a 50-year endeavour
  6. 73186
    “…Most participants (88.7%) in care were on ARV treatment (ART). Only about one-quarter of all HIV-infected participants were virally suppressed. …”
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    HIV testing and the HIV care continuum among sub-Saharan African men who have sex with men and transgender women screened for participation in HPTN 075
  7. 73187
    “…This multicentre, randomised, double-blind, placebo-controlled phase 2 clinical trial enroled between January 2014 and March 2015 HIV-1-infected patients under ART with plasma HIV RNA levels below 50 copies/mL and CD4 counts between 200 and 500 cells/μL. …”
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    HIV therapeutic vaccine enhances non-exhausted CD4(+) T cells in a randomised phase 2 trial
  8. 73188
    “…In this review, each approach to visual prostheses is described, including advantages and disadvantages as well as assessments of the current state of the art. Most of the work to-date has been targeting stimulation of (a) the retina, with three devices approved for general use and two more in clinical testing; (b) the lateral geniculate nucleus, with efforts still in the pre-clinical stage; and (c) the cortex, with three devices in clinical testing and none currently approved for general use despite the longest history of investigation of the three major approaches. …”
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    Contemporary approaches to visual prostheses
  9. 73189
    por Flowers, T. H., Smith, M. J., Brunton, J.
    Publicado 2019
    “…The cloths studied came from collections held at the Hunterian, University of Glasgow, the Economic Botany Collection, Royal Botanic Gardens Kew and the Centre for Textile Conservation and Technical Art History, University of Glasgow. HPLC analysis was carried out following a sequential extraction procedure to minimise changes to the colorants during extraction. …”
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    Colouring of Pacific barkcloths: identification of the brown, red and yellow colourants used in the decoration of historic Pacific barkcloths
  10. 73190
    “…As Youth Living With HIV/AIDS (YLWHA) continue to survive and live with HIV chronically due to effective Antiretroviral Therapy (ART), it is paramount to work toward maximising their psychosocial wellbeing. …”
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    Youth living with HIV/AIDS in secondary schools: perspectives of peer educators and patron teachers in Western Uganda on stressors and supports
  11. 73191
    “…Overall, in this work we present a set of ConvNet architectures for the prediction of compound activity from their Kekulé structure representations with state-of-the-art performance, that require no generation of compound descriptors or use of sophisticated image processing techniques. …”
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    KekuleScope: prediction of cancer cell line sensitivity and compound potency using convolutional neural networks trained on compound images
  12. 73192
    “…In this article, we present a new computational network, PropaNet, to investigate dynamics of TF networks from time-series transcriptome data using two state-of-the-art network analysis techniques, influence maximization and network propagation. …”
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    PropaNet: Time-Varying Condition-Specific Transcriptional Network Construction by Network Propagation
  13. 73193
    “…The risk for non-Hodgkin lymphoma (NHL) is markedly increased in persons living with human immunodeficiency virus (HIV) infection, and remains elevated in those on anti-retroviral therapy (cART). Both the loss of immunoregulation of Epstein-Barr virus (EBV) infected cells, as well as chronic B-cell activation, are believed to contribute to the genesis of AIDS-related NHL (AIDS-NHL). …”
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    Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL
  14. 73194
    “…It achieves an average area under the receiver operating characteristics curve of 0.840 and area under the precision–recall curve of 0.581 over 4184 GO functional categories, which are significantly higher than the state-of-the-art methods. We further validate the prediction results by analyzing the correlation between functional similarity, sequence similarity, expression similarity and structural similarity, as well as the consistency between the predicted functions and some well-studied functional features of isoform sequences. …”
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    DIFFUSE: predicting isoform functions from sequences and expression profiles via deep learning
  15. 73195
    “…In this review, the current state of the art about the use of collagen-based strategies, mainly as a coating material for the functionalization of vascular graft luminal surface, as a drug delivery system for the release of pro-endothelialization factors, and as physiologically relevant in vitro vascular models, and the future trend in this field of research will be presented and discussed.…”
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    Collagen-Based Tissue Engineering Strategies for Vascular Medicine
  16. 73196
    “…Also, the frequency of α4β7(+) cells was significantly lower in peripheral blood CD4(+) effector memory T cells of HIV-infected compared to healthy individuals and this reduced frequency did not recover in HIV patients on ART. Conversely, the frequency of peripheral blood naïve α4β7(+) CD4(+) T cells was significantly reduced under VDZ treatment. …”
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    Comparison of the integrin α4β7 expression pattern of memory T cell subsets in HIV infection and ulcerative colitis
  17. 73197
    “…Due to the sustained prevalence of human immunodeficiency virus (HIV)-1 associated neurocognitive disorders (HAND) in the post-combination antiretroviral therapy (cART) era, as well as the increased prevalence of older HIV-1 seropositive individuals, there is a critical need to develop adjunctive therapeutics targeted at preserving and/or restoring neurocognitive function. …”
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    Neurorestoration of Sustained Attention in a Model of HIV-1 Associated Neurocognitive Disorders
  18. 73198
    “…In this proof of concept we used state-of-the-art functional metagenomics analytical tools to explore previously reported datasets of bacteria found in male and female Ixodes ovatus, Ixodes persulcatus, and Amblyomma variegatum. …”
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    Sex-Specific Linkages Between Taxonomic and Functional Profiles of Tick Gut Microbiomes
  19. 73199
    por Song, Jingyan, Xiang, Shan, Sun, Zhengao
    Publicado 2019
    “…We implemented a large retrospective cohort study in a single assisted reproductive technology (ART) unit at a university-based hospital, including 1540 autologous FET cycles performed in freeze-all cycles. …”
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    Frozen embryo transfer at the cleavage stage can be performed within the first menstrual cycle following the freeze-all strategy without adversely affecting the live birth rate: A STROBE-compliant retrospective study
  20. 73200
    “…To address these challenges, we developed and validated state-of-the-art deep learning methods that identify patient outcomes from clinical notes without requiring hand-labeled training data. …”
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    Medical device surveillance with electronic health records
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