“…To illustrate their use, we applied the methods to low-coverage sequencing data from human populations of East Asian and European ancestries and show that the implemented selection statistics can control the false positive rate and that they identify the same signatures of selection from low-coverage sequencing data as state-of-the-art software using high quality called genotypes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…To further our understanding of neuromodulation therapies, there is a critical need for novel methodological approaches using state-of-the-art neuroscience tools to study neuromodulation therapy in preclinical models of disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In addition, the state of the art of the pharmaceutical industry has experienced stagnation in the past 30years, which has pushed pathogenic infections to get one step ahead, resulting in the development of resistance to existing treatments. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…TB and HIV patients were treatment naïve while TB/HIV patients were both ART naïve and experienced but not yet started TB therapy. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: This large-scale, population-based cohort study did not show that use of statins was associated with a reduced risk of acute exacerbations in patients with COPD using state-of-the-art pharmacoepidemiologic approaches. The findings emphasize the importance of applying appropriate methodology in exploring statin effectiveness in real-world settings.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS AND RESULTS: A total of 373 patients hospitalized for HF [mean age 74.8 (±12.1) years; 118 (31.6%) women] were retrieved from the HeARt and brain failure inVESTigation trial (HARVEST‐Malmö). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Through experimental verification, our method outperforms state-of-the-art PPI prediction models.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: There is no clear clinical conclusion on whether assisted reproductive technology (ART) increases maternal and child risk and affects infant birth and development. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: COMETA (Clinical-epidemiOlogical prograM of studying psychosocial risk factors in cardiological practice in patiEnts with arterial hyperTension and ischemic heArt disease) is a multicenter cross-sectional study performed in 30 big cities of Russia with two to five out-patient clinics per city randomly selected and two to five general practitioners (GPs) per an out-patient clinic. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Moreover, only for three of these 24 instances, the optimal solution is known, leading the authors of a state-of-the-art heuristic to conclude “HarwellBoeing instances are actually a challenge for modern heuristic methods”. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…When applied to the problem of imputing missing data in single-cell RNAseq data, the Graph Feature Auto-Encoder utilizing our new graph convolution layer called FeatGraphConv outperformed a state-of-the-art imputation method that does not use protein interaction information, showing the benefit of integrating biological networks and omics data with our proposed approach. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Our results indicate that the proposed srBERT(my) model, pre-trained with abstracts of articles and a generated vocabulary, achieved state-of-the-art performance in both classification and relation-extraction tasks; for the first task, it achieved an accuracy of 94.35% (89.38%), F1 score of 66.12 (78.64), and area under the receiver operating characteristic curve of 0.77 (0.9) on the original and (generated) datasets, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In comparison to current state-of-the-art methodologies, the proposed model performed well. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Modest changes were observed baseline to follow-up: among all participants, any condomless anal intercourse past 3 months (74.6%–66.7%, P = 0.064); among HIV-negative participants (N = 82) HIV testing past 6 months (80.7%–87.2%, P = 0.166); among HIV-positive participants (N = 34) receiving HIV primary care past 6 months (64.5%–78.8%, P = 0.139), and adherent to ART past 30 days (22.6%–28.1%, P = 0.712). 86% would be willing to refer a friend to the app, and 65% found the app to be personally relevant. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Convolutional neural networks (CNNs) are the state-of-the-art image segmentation technique, but require large annotated datasets for training. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Pretreatment drug resistance (PDR) can limit the effectiveness of HIV antiretroviral therapy (ART). The aim of this study was to assess the prevalence of PDR among HIV-positive individuals that initiated antiretroviral therapy in 2014–2020 in southwestern China. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The estimation pipeline combines state-of-the-art techniques with new approaches to estimating the target’s unknown properties across all phases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The developed guideline provides state-of-the-art information and presents the conclusions and recommendations of the consensus panel regarding these issues. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…While MRD quantification from bone marrow prior to HSCT remains the state of the art, heavily pre-treated patients may benefit from additional staging, such as using (18)F-fluorodeoxyglucose positron emission tomography/computed tomography to detect focal residues of disease. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Aortic root dimensions were measured using state-of-the-art cardiac ultrasound, including the aortic annulus, sinus of Valsalva, sinotubular junction (STJ), and ascending aorta, in diastole and systole. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso