“…RESULTS: Our extensions to the STADEN package provide the following functionality to facilitate microsatellite (and also minisatellite) marker design: The new modules (i) integrate the state-of-the-art tandem repeat detection and analysis software PHOBOS into workflows, (ii) provide two separate repeat detection steps – with different search criteria – one for masking repetitive regions during assembly of sequencing reads and the other for designing repeat-flanking primers for MS candidate loci, (iii) incorporate the widely used primer design program PRIMER3 into STADEN workflows, enabling the interactive design and visualization of flanking primers for microsatellites, and (iv) provide the functionality to find optimal locus- and primer pair combinations for multiplex primer design. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Meta-analysis with 95% confidence showed that, despite similar implantation rates, fresh double-embryo transfer had a 1.64 to 2.60 times greater ongoing pregnancy rate and 1.44 to 2.42 times greater live birth rate than single-embryo transfer in a population suitable for ART treatment.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…No trends were seen for education level, family income, distance travelled to clinic, time since diagnosis, or time on ART. CONCLUSION: Regular attendance for follow up was statistically significant for 100% lifetime adherence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Our proposed methods MKLdiv-dc and MKLdiv-conv are able to achieve state-of-the-art performance on the SCOP PDB-40D benchmark dataset for protein fold prediction and provide useful insights into the relative significance of informative data sources. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Median costs per admission of diagnostic and therapeutic services (laboratory investigations, radiology, intravenous fluids and blood, and non-ART medications) were higher in the HAART group compared with the no-HAART group (US$190 versus US$111; p = 0.001), but the more expensive non-curative costs (overhead, capital, and clinical staff) were not significantly different (US$1199 versus US$1128; p = 0.525). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Tai Chi is a traditional Chinese martial art which combines slow and gentle movements with mental focus. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…This new strategy that integrates expression profiling, genetics and novel computational biology approaches provides for improved efficiency in characterization and modeling of microRNA functions in cancer as compared to the state of art and is applicable to the investigation of microRNA functions in other biological processes and diseases.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: The objective was to assess the current state of the art in the presentation of online comparative health care information and to compare how the integration of different information types is dealt with on websites. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Further research is needed to assess this approach in populations with widely available HIV treatment (ART).…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We performed sensitivity analyses on HIV prevalence and incidence, cost estimates, and the transmission benefits of ART. “Current practice” produced LEs of 242.82 quality-adjusted life months (QALM) among HIV-infected persons and 268.77 QALM in the general population. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We showed that it correctly predicts known interactions from proteomes of different organisms and is more accurate and precise at proteome scanning compared with published state-of-the-art predictors.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Best reported values of sensitivity (85%), specificity (100%), and precision (98%) for predicting X4-capable HIV-1 virus, overall accuracy (97%), Matthew's correlation coefficient (89%), balanced error rate (0.08), and ROC area (0.97) all reach critical thresholds, suggesting that the models outperform six other state-of-the-art methods and come closer to competing with phenotype assays. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: Our novel heuristic gives birth to a state of the art program, sMCL-WMR, that is capable of detecting weak motifs in data sets with a large number of strings. sMCL-WMR is orders of magnitude faster than its predecessor MCL-WMR and is capable of solving previously unsolved synthetic motif recognition problems. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: We have demonstrated the superiority and stability of our algorithms by performing comprehensive experimental comparisons with nine state-of-the-art algorithms on six high-dimensional heterogeneous profiles under cross validations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The aim of this study was to test seven previously published image-input methods in state-of-the-art high resolution PET brain images. Images were obtained with a High Resolution Research Tomograph plus a resolution-recovery reconstruction algorithm using two different radioligands with different radiometabolite fractions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: When DNA contamination was avoided and state-of-the-art highly sensitive HPV DNA detection assays were used, we found no evidence that HPV was associated with lung cancer in a representative Western population. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: In this hospital-based cross-sectional study, 93 known HIV positive females attending a pre-ART registration clinic and 1106 HIV negative females attending a Reproductive and Child Health Care Clinic were subjected to study. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The Anduril framework allows rapid integration of heterogeneous data with state-of-the-art computational methods and existing knowledge in bio-databases. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Single-genome sequencing (SGS) of full-length RT was carried out on sequential samples from an HIV-infected individual enrolled in ART rollout. The emergence of Q151M MDR occurred in the order A62V, V75I, and finally Q151M on the same genome at 4, 17 and 37 months after initiation of therapy, respectively. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: CD4(+) T-lymphocyte count (CD4 count) is a standard method used to monitor HIV-infected patients during anti-retroviral therapy (ART). The World Health Organization (WHO) has pointed out or recommended that a handheld, point-of-care, reliable, and affordable CD4 count platform is urgently needed in resource-scarce settings. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso