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  1. 73821
    “…The main analytical challenge for studying variation in MUPs, even for state-of-the-art proteomics techniques, is their high degree of amino acid sequence homology. …”
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    Regulation of highly homologous major urinary proteins in house mice quantified with label-free proteomic methods
  2. 73822
    “…There was significant difference on risk of composite outcome between patients who were initiated with Tenofovir containing ART regimen compared with zidovudine after controlling for NNRTI drug combinations.…”
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    Modeling Outcomes of First-Line Antiretroviral Therapy and Rate of CD4 Counts Change among a Cohort of HIV/AIDS Patients in Ethiopia: A Retrospective Cohort Study
  3. 73823
    “…Experiments show that the proposed method improves results over 4 state-of-the-art methods. In addition, we simulated cases for new drugs and targets to see how our method would perform in predicting their interactions. …”
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    Drug-target interaction prediction via class imbalance-aware ensemble learning
  4. 73824
    “…CONCLUSIONS: Besides demonstrating that the current state of the art clinical PET/CT systems have the same lesion detection ability, the study demonstrates how sensitive scan time can be to detecting small lesions which have a relatively small contrast uptake in the range of just 2:1. …”
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    Minimum lesion detectability as a measure of PET system performance
  5. 73825
    “…CONCLUSION: In the present study, we demonstrated the use of a complex 3D tetraculture system together with a state-of-the-art aerosol exposure equipment to study the effects of in vivo relevant doses of DEPM on endothelial cells in vitro. …”
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    Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter
  6. 73826
    “…To conclude, in this preliminary work, we have implemented state-of-the-art automatic segmentation and SSA methods, and we have shown how they could improve our understanding of ventricular kinetics by visually and potentially quantitatively highlighting aspects that are usually not picked up by traditional approaches.…”
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    Investigating Cardiac Motion Patterns Using Synthetic High-Resolution 3D Cardiovascular Magnetic Resonance Images and Statistical Shape Analysis
  7. 73827
    “…In the final model (157 cases), adjusted for age, previous episode of CM, ART use, type of antifungal treatment, raised intracranial pressure, frequency of therapeutic lumbar punctures, baseline fungal burden and treatment period, the factors associated with early mycological clearance were: Amphotericin B deoxycholate plus fluconazole as combination therapy (RR, 1.56; 95% CI, 1.14–2.14); severe baseline intracranial pressure (≥35 cm H(2)O) (RR, 0.57; 95% CI, 0.33–0.99); and baseline fungal burden over 4.5 log(10) CFU/mL (RR, 0.61 95% CI: 0.39–0.95). …”
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    Factors associated with early mycological clearance in HIV-associated cryptococcal meningitis
  8. 73828
    “…CONCLUSION: State-of-the-art phosphoproteomics approaches focusing on single cell analysis have the potential to better understand oncogenic signaling in heterogeneous cell populations including rare, yet highly malignant CSC. …”
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    Understanding cell signaling in cancer stem cells for targeted therapy – can phosphoproteomics help to reveal the secrets?
  9. 73829
    “…RESULTS: Most policies were widely implemented in both HDSS (free testing, free antiretroviral treatment (ART), WHO first-line regimen as standard, Option B+). …”
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    HIV policy implementation in two health and demographic surveillance sites in Uganda: findings from a national policy review, health facility surveys and key informant interviews
  10. 73830
    “…The persistence of this bias despite state-of-the-art pharmacoepidemiologic methods calls into question the ability of claims data to address confounding in studies of BBs in patients with COPD.…”
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    Evidence of potential bias in a comparison of β blockers and calcium channel blockers in patients with chronic obstructive pulmonary disease and acute coronary syndrome: results of a multinational study
  11. 73831
    “…The CD processed L1000 signatures are served through a state-of-the-art web-based search engine application called L1000CDS(2). …”
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    L1000CDS(2): LINCS L1000 characteristic direction signatures search engine
  12. 73832
    “…CONCLUSIONS: The dMAGA-FCM(D) is compared with the other four algorithms which are all state-of-the-art FCM training algorithms, and the results show that the dMAGA-FCM(D) performs the best. …”
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    A time series driven decomposed evolutionary optimization approach for reconstructing large-scale gene regulatory networks based on fuzzy cognitive maps
  13. 73833
    “…The development of effective approaches to increase HIV diagnoses and engage PLWH in subsequent steps of the treatment cascade could lead to earlier and sustained ART treatment resulting in viral suppression. There is an unmet need for research applying the treatment cascade to improve outcomes for those with criminal justice involvement. …”
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    Cohort profile: seek, test, treat and retain United States criminal justice cohort
  14. 73834
    “…Up to 28% of patients (36% of those on ritonavir-boosted protease inhibitors, PI/r) underwent antiretroviral (ART) modification at DAA initiation. 545/595 (91.6%) patients reaching EOT achieved SVR12. …”
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    Access and response to direct antiviral agents (DAA) in HIV-HCV co-infected patients in Italy: Data from the Icona cohort
  15. 73835
    “…Here, we review state-of-the-art MR methods to study brain function and metabolism in vivo, and their contribution to the current understanding of how astrocytic energy metabolism supports glutamatergic activity and cerebral function. …”
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    How Energy Metabolism Supports Cerebral Function: Insights from (13)C Magnetic Resonance Studies In vivo
  16. 73836
    “…BACKGROUND: Sustained viral suppression through ART reduces sexual HIV transmission risk, but may require routine access to reliable and effective medical care which may be difficult to obtain in resource constrained areas. …”
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    Effects of patient load and travel distance on HIV transmission in rural China: Implications for treatment as prevention
  17. 73837
    “…Some mothers were hesitant of lifelong ARVs, rationalizing the debated paradigm that prolonged chemotherapy/polypharmacy may be a future challenge in the success of ART in PMTCT. Conflicting breast feeding practices was a common observation across mothers thus underpinning the need to strongly invigorate Infant and Young Child Feeding information sharing across the continuum of heath care from facility level to community and up to the family; for cultural norms, practices and attitudes enshrined within communities play a vital role in child care.…”
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    Challenges and opportunities of optimal breastfeeding in the context of HIV option B+ guidelines
  18. 73838
    “…RESULTS: We present the results of a thorough benchmarking of state-of-the-art single- and multi-chain sampling methods, including Adaptive Metropolis, Delayed Rejection Adaptive Metropolis, Metropolis adjusted Langevin algorithm, Parallel Tempering and Parallel Hierarchical Sampling. …”
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    Comprehensive benchmarking of Markov chain Monte Carlo methods for dynamical systems
  19. 73839
    “…In this review, we present a state-of-the-art flow chart that guides care providers in the treatment of morphea and EF.…”
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    Morphea and Eosinophilic Fasciitis: An Update
  20. 73840
    “…Conclusions: There are undeniable clinical and public health benefits to AHI detection and treatment, but also substantial diagnostic and logistical barriers to implementation and scale-up. Effective early ART initiation may be critical for HIV eradication efforts, but widespread use in LMIC requires simple and accurate diagnostic tools. …”
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    Clinical and public health implications of acute and early HIV detection and treatment: a scoping review
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