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75941“…RESULTS: The proposed drug repositioning approach is threefold; (i) clustering drugs based on their homogeneous profiles using the Growing Self Organizing Map (GSOM); (ii) clustering drugs based on drug-drug relation matrices based on the previous step, considering three state-of-the-art graph clustering methods; and (iii) inferring drug repositioning candidates and assigning a confidence value for each identified candidate. …”
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75942por Bevelander, Kirsten E., Smit, Crystal R., van Woudenberg, Thabo J., Buijs, Laura, Burk, William J., Buijzen, Moniek“…In addition, the Wearable Lab is developed to enable an attractive and state-of-the-art way of collecting data and online campaign implementation via social networks. …”
Publicado 2018
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75943“…For the neural network system, we exploited the state-of-the-art recurrent neural network (RNN) and attention models. …”
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75944por Brenner, Thorsten, Decker, Sebastian O., Grumaz, Silke, Stevens, Philip, Bruckner, Thomas, Schmoch, Thomas, Pletz, Mathias W., Bracht, Hendrik, Hofer, Stefan, Marx, Gernot, Weigand, Markus A., Sohn, Kai“…Although this new approach might be more sensitive and specific than culture-based state-of-the-art technologies, additional clinical trials are needed to exactly define the performance as well as clinical value of a NGS-based approach. …”
Publicado 2018
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75945por Cluver, Lucie, Pantelic, Marija, Orkin, Mark, Toska, Elona, Medley, Sally, Sherr, Lorraine“…METHODS: Clinical and interview data were gathered from N = 1060 adolescents living with HIV in rural and urban South Africa in 2014 to 2015. All ART‐initiated adolescents from 53 government health facilities were identified, and traced in their communities to include those defaulting and lost‐to‐follow‐up. …”
Publicado 2018
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75946“…RESULTS: Among patient characteristics most likely to promote use of digital health tools, experts endorsed interest in using state-of-the-art technology, availability of necessary resources, good occupational functioning, and perception of the tool as beneficial. …”
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75947por Al Manir, Mohammad Sadnan, Brenas, Jon Haël, Baker, Christopher JO, Shaban-Nejad, Arash“…The platform significantly extends the range of functionalities offered by malaria information systems, beyond the state-of-the-art.…”
Publicado 2018
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75948por Luma, Henry Namme, Jua, Paulia, Donfack, Olivier-Tresor, Kamdem, Felicite, Ngouadjeu, Eveline, Mbatchou, Hugo Bertrand, Doualla, Marie-Solange, Mapoure, Yakouba Njankou“…BACKGROUND: The introduction of anti-retroviral treatment (ART) has significantly reduced mortality and morbidity associated with HIV/AIDS. …”
Publicado 2018
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75949por Kim, Hae‐Young, Dowdy, David W, Martinson, Neil A, E Golub, Jonathan, Bridges, John F P, Hanrahan, Colleen F“…We quantified changes in priorities related to isoniazid preventive therapy (IPT) and antiretroviral therapy (ART) among pregnant women living with HIV. METHODS: We enrolled pregnant women recently diagnosed with HIV from 14 primary health clinics during pregnancy and followed them after delivery in Matlosana, South Africa. …”
Publicado 2018
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75950por Roychoudhury, Pavitra, De Silva Feelixge, Harshana, Reeves, Daniel, Mayer, Bryan T., Stone, Daniel, Schiffer, Joshua T., Jerome, Keith R.“…While increased doses may overcome low target cleavage efficiency, inadequate targeting of rare strains is predicted to lead to rebound upon cART cessation even with many doses. CONCLUSIONS: Target site selection must account for global and within host viral genetic diversity. …”
Publicado 2018
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75951“…BACKGROUND: Antiretroviral therapy (ART) has become the standard of care for patients with HIV infection in South Africa and has led to the reduction in AIDS related morbidity and mortality. …”
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75952“…We disagree that allowing sequences as types would fundamentally alter the nature of types, since a similar nature of abstracted features as type is already allowed in the Code (Art. 40.5), namely an illustration. We also disagree that there is a high risk of introducing artifactual taxa, as this risk can be quantified at well below 5 %, considering the various types of high-throughput sequencing errors. …”
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75953por Duan, Yuting, Lu, Liming, Chen, Juexuan, Wu, Chunxiao, Liang, Jielin, Zheng, Yan, Wu, Jinjian, Rong, Peijing, Tang, Chunzhi“…We included trials of home-based exercise(HE), group exercise(GE), walking program(WP), reminiscence therapy(RT), art therapy(AT) or the combination of psychosocial interventions and acetylcholinesterase inhibitor (ChEIs). …”
Publicado 2018
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75954por Chan, Joe Mee, Sukumar, Alvin Isaac, Ramalingam, Magendra, Ranbir Singh, Surinder Singh, Abdullah, Mohamad Farouk“…METHODS: This was a retrospective cohort study performed for 162 women to assess the associations between EMT on the human chorionic ganadotropin (hCG) trigger day and pregnancy outcomes in infertile patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) and autologous fresh embryo transfer (ET) in controlled ovarian stimulation (COS) cycles under an assisted reproductive technology (ART) shared-care programme between public and private institutions from January 2012 through December 2016. …”
Publicado 2018
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75955por Dovel, Kathryn, Shaba, Frackson, Nyirenda, Mike, Offorjebe, O. Agatha, Balakasi, Kelvin, Phiri, Khumbo, Nichols, Brooke, Tseng, Chi-Hong, Bardon, Ashley, Ngona, Khumbo, Hoffman, Risa“…Secondary outcome measures are the proportion of OPD clients newly identified as HIV-positive and antiretroviral therapy (ART) initiation. Costs and cost-effectiveness will be evaluated. …”
Publicado 2018
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75956por Arimide, Dawit Assefa, Abebe, Almaz, Kebede, Yenew, Adugna, Fekadu, Tilahun, Tesfaye, Kassa, Desta, Assefa, Yibeltal, Balcha, Taye Tolera, Björkman, Per, Medstrand, Patrik“…METHODS: A cross-sectional survey was conducted among young antiretroviral therapy (ART)-naïve individuals recently diagnosed with HIV infection, in Gondar, Ethiopia, 2011–2013 using the WHO recommended threshold survey. …”
Publicado 2018
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75957por Natsiavas, Pantelis, Rasmussen, Janne, Voss-Knude, Maja, Votis, Κostas, Coppolino, Luigi, Campegiani, Paolo, Cano, Isaac, Marí, David, Faiella, Giuliana, Clemente, Fabrizio, Nalin, Marco, Grivas, Evangelos, Stan, Oana, Gelenbe, Erol, Dumortier, Jos, Petersen, Jan, Tzovaras, Dimitrios, Romano, Luigi, Komnios, Ioannis, Koutkias, Vassilis“…Sustainability plans shall be defined for adapting existing/evolving frameworks to the state-of-the-art. Overall, lack of integration in a holistic security approach was clearly identified. …”
Publicado 2018
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75958por Taubert, Mark, Norris, James, Edwards, Sioned, Snow, Veronica, Finlay, Ilora Gillian“…There has also been a collaboration with Falmouth University Art College, who helped produce graphic designs to facilitate and encourage discussions about CPR and end of life care. …”
Publicado 2018
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75959por Lancaster, Kathryn E, Hoffman, Irving F, Hanscom, Brett, Ha, Tran Viet, Dumchev, Kostyantyn, Susami, Hepa, Rose, Scott, Go, Vivian F, Reifeis, Sarah A, Mollan, Katie R, Hudgens, Michael G, Piwowar‐Manning, Estelle M, Richardson, Paul, Dvoriak, Sergii, Djoerban, Zubairi, Kiriazova, Tetiana, Zeziulin, Oleksandr, Djauzi, Samsuridjal, Ahn, Chu Viet, Latkin, Carl, Metzger, David, Burns, David N, Sugarman, Jeremy, Strathdee, Steffanie A, Eshleman, Susan H, Clarke, William, Donnell, Deborah, Emel, Lynda, Sunner, Lisa E, McKinstry, Laura, Sista, Nirupama, Hamilton, Erica L, Lucas, Jonathan P, Duong, Bui D, Van Vuong, Nguyen, Sarasvita, Riza, Miller, William C“…HPTN 074 was designed to determine the feasibility, barriers and uptake of an integrated intervention combining health systems navigation and psychosocial counselling for the early engagement of antiretroviral therapy (ART) and substance use treatment for PWID living with HIV. …”
Publicado 2018
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75960por Schipp, Cyrill, Schlütermann, David, Hönscheid, Andrea, Nabhani, Schafiq, Höll, Jessica, Oommen, Prasad T., Ginzel, Sebastian, Fleckenstein, Bernhard, Stork, Björn, Borkhardt, Arndt, Stepensky, Polina, Fischer, Ute“…Serine/threonine kinase 4 (STK4) deficiency is an autosomal recessive genetic condition that leads to primary immunodeficiency (PID) typically characterized by lymphopenia, recurrent infections and Epstein Barr Virus (EBV) induced lymphoproliferation and -lymphoma. State-of-the-art treatment regimens consist of prevention or treatment of infections, immunoglobulin substitution (IVIG) and restoration of the immune system by hematopoietic stem cell transplantation. …”
Publicado 2018
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