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  1. 76761
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    Novel pentacyclic derivatives and benzylidenes of the progesterone series cause anti-estrogenic and antiproliferative effects and induce apoptosis in breast cancer cells
  2. 76762
    “…In a cohort of Alzheimer’s disease cases [n = 1439, mean age 68 years (standard deviation = 8.2)] and screened controls [n = 508, mean age 82 years (standard deviation = 6.8)], we measured plasma concentrations of the 40 and 42 amino acid-long amyloid-β (Aβ) fragments (Aβ(40) and Aβ(42), respectively), tau phosphorylated at amino acid 181 (P-tau181), neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) using state-of-the-art Single molecule array (Simoa) technology. We tested the relationships between the biomarkers and Alzheimer’s disease genetic risk, age at onset and disease duration. …”
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    Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease
  3. 76763
    “…Current studies investigated whether estradiol generated by the enzyme aromatase acts within the key component of central nervous system regulation of glucose balance, the ventromedial hypothalamic nucleus, to regulate metabolic-sensitive neurochemical signaling. Here, state-of-the-art reagents for manipulation of in vivo aromatase gene expression were stereotactically delivered to that nucleus to investigate whether this enzyme protein is essential for optimal insulin-induced hypoglycemia-associated patterns of local neurotransmitter synthesis, involving microdissection-harvesting of pure glucose-stimulatory and glucose-inhibitory neuron cell samples and plasma glucose counter-regulatory hormone profiles. …”
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    Effects of Ventromedial Hypothalamic Nucleus (VMN) Aromatase Gene Knockdown on VMN Glycogen Metabolism and Glucoregulatory Neurotransmission
  4. 76764
    “…Factors adjusted in the final models include sex of infant, mother's baseline BMI, age in years, ART regimen, viral load, CD4 count, education, and household food insecurity. …”
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    Effect of pregnancy versus postpartum maternal isoniazid preventive therapy on infant growth in HIV-exposed uninfected infants: a post-hoc analysis of the TB APPRISE trial
  5. 76765
    “…STUDY QUESTION: What is the current state-of-the-art methodology assessing decellularized extracellular matrix (dECM)-based artificial ovaries for treating ovarian failure? …”
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    Extracellular matrix-derived scaffolds in constructing artificial ovaries for ovarian failure: a systematic methodological review
  6. 76766
    “…Data will be collected in various forms, including expressive forms (eg, art and spoken word) and traditional methods (interview transcription and surveys), with phenomenographic and thematic analyses being used to understand these data. …”
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    Developing a System of Health Support for Young People Experiencing First-Episode Psychosis: Protocol for a Co-design Process
  7. 76767
    “…Main funding source(s): European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska- Curie grant agreement INTRODUCTION: Although the effective refractory period (ERP) is one of the main electrophysiological properties governing atrial tachycardia (AT) maintenance, ERP personalization is rarely performed when creating patient-specific computer models of the atria to inform clinical decision making. State-of-the-art models usually do not consider physiological ERP gradients but assume a homogeneous ERP distribution. …”
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    Impact of effective refractory period personalization on prediction of atrial fibrillation vulnerability
  8. 76768
    “…OBJECTIVE: This review aims to map published studies on smart home technologies aimed at promoting physical activity among the general and aging populations to unveil the state of the art, its potential, and the research gaps and opportunities. …”
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    Using Smart Home Technologies to Promote Physical Activity Among the General and Aging Populations: Scoping Review
  9. 76769
    “…METHODS: SMILE is a randomised non-inferiority trial evaluating safety and antiviral efficacy of once-daily INSTI + DRV/r vs. continuing on current standard-of-care (SOC) triple ART (2NRTI + boosted PI/NNRTI) in virologically-suppressed CLWHIV aged 6–18 years. …”
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    Nucleoside/nucleotide reverse transcriptase inhibitor sparing regimen with once daily integrase inhibitor plus boosted darunavir is non-inferior to standard of care in virologically-suppressed children and adolescents living with HIV – Week 48 results of the randomised SMILE Penta-17-ANRS 152 clinical trial
  10. 76770
    “…Overall, compared with other state-of-the-art classifiers such as ET, GBDT and RF, XGBoost algorithm not only showed a more stable performance, but also yielded higher ROC-AUC and PRC-AUC scores, demonstrating its high accuracy in prediction of TiPN occurrence. …”
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    Comparison and development of machine learning for thalidomide-induced peripheral neuropathy prediction of refractory Crohn’s disease in Chinese population
  11. 76771
    “…BACKGROUND: Assisted reproductive technology (ART) has brought good news to infertile patients, but how to improve the pregnancy outcome of poor ovarian response (POR) patients is still a serious challenge and the scientific evidence of some adjuvant therapies remains controversial. …”
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    TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis
  12. 76772
    “…METHODS: This systematic literature review (SLR) investigated the state of the art of voice-based diagnostic and monitoring systems with ML technologies, targeting voice-affecting disorders without direct relation to the voice box from the point of view of applied health technology. …”
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    Applied Machine Learning Techniques to Diagnose Voice-Affecting Conditions and Disorders: Systematic Literature Review
  13. 76773
    “…The system has several key features including a simple and task-focused web user interface, customized PII types, use of a state-of-the-art deep learning model for tagging PII from free text, preannotation by an interactive learning loop, rapid manual annotation with autosave, support for project management and team collaboration, user access control, and central data storage. …”
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    Web-Based Application Based on Human-in-the-Loop Deep Learning for Deidentifying Free-Text Data in Electronic Medical Records: Development and Usability Study
  14. 76774
    “…RESULTS: Our proposed AI model with the all-feature set achieved the highest area under the receiver operating characteristic curve (AUROC) of 0.9974 (adaptive boosting [AdaBoost], AdaBoost + light gradient boosting machine [LightGBM]: Ensemble), outperforming other state-of-the-art machine learning and traditional prediction models, including extreme gradient boosting (AUROC=0.9972), LightGBM (AUROC=0.9973), ICD-based injury severity scores (AUC=0.9328 for the inclusive model and AUROC=0.9567 for the exclusive model), and KTAS (AUROC=0.9405). …”
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    An Artificial Intelligence Model for Predicting Trauma Mortality Among Emergency Department Patients in South Korea: Retrospective Cohort Study
  15. 76775
    “…ChatGPT is a state-of-the-art chatbot capable of creating natural conversations using NLP. …”
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    The Potential of ChatGPT as a Self-Diagnostic Tool in Common Orthopedic Diseases: Exploratory Study
  16. 76776
    “…The practice of medicine includes both the art and the science of the prevention, diagnosis, alleviation, and treatment of disease. …”
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    International EANM-SNMMI-ISMRM consensus recommendation for PET/MRI in oncology
  17. 76777
    “…INTRODUCTION: In December 2019, the Botswana government expanded free antiretroviral therapy (ART) to include non‐citizens. We evaluated the impact of this policy change on antenatal care (ANC), antiretroviral therapy coverage and adverse birth outcomes. …”
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    The impact of free antiretroviral therapy for pregnant non‐citizens and their infants in Botswana
  18. 76778
    “…The second tool is a new external validity index which shows similar performances with respect to the state of the art, but with more flexibility, allowing for a broader spectrum of applications. …”
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    A methodology to assess the intrinsic discriminative ability of a distance function and its interplay with clustering algorithms for microarray data analysis
  19. 76779
    “…Despite nearly two score years of research on RNA secondary structure and RNA–RNA interaction prediction, the accuracy of the state-of-the-art algorithms are still far from satisfactory. …”
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    The RNA Newton polytope and learnability of energy parameters
  20. 76780
    “…This review discusses the current state of art regarding to epidemiologic aspects of PH, diagnostic approaches and the current classification of PH. …”
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    Pulmonary arterial hypertension
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