“…Incorporation into the model of key NS3 protease mutations leading to resistance to BILN-2061 (A156T, D168V, R155Q), VX-950 (A156S, A156T, T54A) and SCH 503034 (A156T, A156S, T54A) inhibitors allows us to describe the long term dynamics of the viral RNA suppression for various inhibitor concentrations. We theoretically showed that the observable difference between the viral RNA kinetics for different inhibitor concentrations can be explained by differences in the replication rate and inhibitor sensitivity of the mutant RNAs. …”
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“…Some viruses can directly infect DC, which theoretically allow direct presentation of viral antigens to CTL, but many viruses target other cells than DC and thus the host depends on the cross-presentation of viral antigens by DC to activate virus-specific CTL. …”
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“…We found that it is theoretically possible to reorganize E. coli genome into 86% fewer regulated operons. …”
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“…The GOLD model (Graph Of Language Distribution) is a network model constructed based on co-occurrence in a large corpus of natural language that may be used to explore what information may be present in a graph-structured model of language, and what information may be extracted through theoretically-driven algorithms as well as standard graph analysis methods. …”
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“…Design Characterization of tobacco control advertisements using a theoretically based framework designed to describe advertisement themes, informational and emotional content and style. …”
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“…BACKGROUND: The concept of an autocatalytic set of molecules has been posited theoretically and demonstrated empirically with catalytic RNA molecules. …”
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“…It is observed that the relative distance l(i) estimated by analytical method and fuzzy set theoretic approach are consistent with each other. …”
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“…This increase in ϕ had been theoretically associated with a decrease in biochemical operating efficiency (expressed as ATP cost of gross assimilation, ATP/GA) under low light and, because a proportion of canopy photosynthesis is carried out by shaded leaves, potential productivity losses at field scale. …”
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“…When applied on parasite-free feces spiked with variable oocysts/cysts counts, ≈ 2 oocysts/cysts were theoretically enough for detection by PCR. To conclude, the Qiagen kit with the amended protocol was proved to be suitable for protozoan DNA extraction directly from feces and support PCR diagnosis.…”
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“…As a solution, Gomez-Herrero and colleagues theoretically showed that the stationarity assumption may be avoided by estimating transfer entropy from an ensemble of realizations. …”
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“…CASE DESCRIPTION: The Girls Just Wanna Have Fun program was designed in response to increased calls for physical activity programs for female youth and is a theoretically-grounded physical activity-based life skills program that aims to empower female youth. …”
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“…Integral feedback is a control theoretic concept which has long been known to keep a controlled variable [Image: see text] robustly (i.e. perturbation-independent) at a given set-point [Image: see text] by feeding the integrated error back into the process that generates [Image: see text]. …”
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“…We examine the information-theoretic concept of Shannon entropy as a model of predictive uncertainty in music cognition. …”
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“…Therefore, we introduced sampling approaches that are much easier to implement. They are also theoretically favorable for several real-life applications, in particular since these primarily concern long-range interactions in very large RNA molecules. …”
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“…RESULTS: The PEG-based prodrug obtained in this study possessed an exceedingly high 5-FA loading efficiency of 10.58%, much higher than the maximum drug loading efficiency of unmodified PEG with the same molecular weight, which was 0.98% theoretically. Furthermore, 5-FA-PAE exhibited suitable sustained release in tumors. …”
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“…CONCLUSIONS: The convergence analysis of the algorithm theoretically shows that the sequence generated from the algorithm converges to the optimal solution of the problem. …”
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“…This study demonstrated that impulsive processes may play a unique role in predicting spontaneous physical activity behaviors. Theoretically, this finding reinforces the utility of a motivational approach based on dual-process models to explain inter-individual differences in NEAT. …”
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“…However, its localization in large and thick plant organs (e.g., stem, roots, and fruits), other than leaves, has proven to be challenging due to the difficulties for the commonly used H(2)O(2)-specific chemicals, such as 3,3′-diaminobenzidine (DAB), cerium chloride (CeCl(3)), and 2′,7′-dichlorofluorescin diacetate (H(2)DCF-DA), to penetrate those organs. Theoretically, the reaction of endogenous H(2)O(2) with these chemicals could be facilitated by using thin organ sections. …”
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“…RESULTS: We found that out of 857 globular enzymes, at least 219 have a discrete punctuate localization in the cytoplasm and catalyze the first or the last reaction in 60% of biosynthetic pathways. A graph-theoretic analysis of E.coli’s metabolic network shows that localized enzymes, in contrast to non-localized ones, form a tree-like hierarchical structure, have a higher within-group connectivity, and are traversed by a higher number of feed-forward and feedback loops than their non-localized counterparts. …”
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“…Furthermore, cross fertilization has not been observed in vitro and even in parasites with dog intestinal origin; although it theoretically is possible. During a follow-up of cultivated adult worms, evidences of behaviors similar to self-mating (Type 2) and cross-mating were observed in our lab which will be presented here. …”
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