“…A stromal score was generated using the ESTIMATE algorithm, and the likelihood of response to PD-1/PD-L1 immunotherapy of GC patients was predicted using the TIDE algorithm. The prognostic value of the stromal score from GC cases was evaluated by the Kaplan–Meier method and Cox regression analysis. …”
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“…We assessed the patient’s response to immunotherapy using the tumor immune dysfunction and exclusion (TIDE) score and immunophenoscore (IPS). Furthermore, we validated the predictive power of GBP1 expression in four independent immunotherapy cohorts. …”
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“…Furthermore, we calculated immune cell infiltration, immune checkpoint, the T-cell receptor/B-cell receptor (TCR/BCR), SNV, and Tumor Immune Dysfunction and Exclusion (TIDE) scores in TCGA database. We also validated our model with an immunotherapy cohort. …”
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“…IDH1mt glioma tissues from patients with high-risk scores showed more infiltration of M1 and CD8 T cells than those from patients with low-risk scores. Moreover, TIDE analysis showed that immune checkpoint blockade(ICB) therapy was highly beneficial for IDH1mt patients with high-risk scores. …”
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“…The Tumor Immune Dysfunction and Exclusion (TIDE) algorithm was used to predict SERPINA1’s response to ICIs. …”
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“…Independent immunotherapy datasets (IMvigor210 and GSE78220), TIDE, IPS and pRRophetic analyses revealed that the low-risk group responded better to common immunotherapy and chemotherapy drugs. …”
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“…Notably, the levels of immune checkpoint genes such as CTLA-4, PDCD-1, and CD274, and the TIDE scores were significantly higher in the low-risk subgroups than in high-risk subgroups (p < 0.001). …”
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“…A wide range of sessile organisms are partially or fully emersed (exposed above the water line) during low tide. In the tropics, when corals are emersed, high light and temperature can be detrimental to their survival. …”
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“…The rising tide of obesity and its related disorders is one of the most pressing health concerns worldwide, yet existing medicines to combat the problem are disappointingly limited in number and effectiveness. …”
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“…Understanding the molecular mechanisms and signaling pathways that lead to these differences in susceptibility to insulin resistance will equip us with important targets to help stem the tide of such debilitating diseases. Here we discuss an emerging theory that chronic, low-grade endotoxemia may represent a causal factor in obesity-related inflammatory states, and that diet-induced changes in the gut microbiome may be a key regulator of metabolic health. …”
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“…The AACR is committed to increasing its efforts to stem the tide of cancer worldwide by promoting innovative programs, strategies, and initiatives for cancer researchers and all those engaged in cancer-related biomedical sciences around the world.…”
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“…Rhythmic sandstone-mudstone-coal succession of the Barakar Formation (early Permian) manifests a transition from lower braided-fluvial to upper tide-wave influenced, estuarine setting. Monospecific assemblage of marine trace fossil Chondrites isp. in contemporaneous claystone beds in the upper Barakar succession from two Gondwana basins (namely, the Raniganj Basin and the Talchir Basin) in eastern peninsular India signifies predominant marine incursion during end early Permian. …”
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“…However, current approaches for vector control are not stemming the rising tide of dengue disease throughout the tropical world. …”
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“…Available therapies for chronic HBV infection mainly include nucleos/tide analogues (NAs), non-NAs, and immunomodulatory agents. …”
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“…Paine (American ecologist, 1933–2016) discovered that if you remove starfish – what he called a “keystone species” – from a tide pool, the complex ecosystem collapses. Without the predator starfish, mussels choke out other animals and plants. …”
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“…His basic work has since influenced initiatives such as the San Francisco Declaration on Research Assessment (DORA), the Leiden Manifesto for research metrics, and The Metric Tide review on the role of metrics in research assessment and management. …”
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“…Site displacements due to solid earth tide loading are also considered for the purpose of improving the positioning accuracy, particularly in the height direction. …”
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“…The approaches described in this study are an important contribution toward pinpointing the origins of this infection and underscore the need for more rigorous international biosecurity in order to stem the tide of emerging fungal pathogens.…”
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“…Mit der künstlichen Niere wurde die moderne Medizin mit einem Apparat bereichert, „which might tide over a dangerous crisis“ (Abel). Sie kann jedoch keinesfalls als vollwertiger Ersatz für ein menschliches Organ angesehen werden. …”
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“…Recent developments of post genomics approaches and bioinformatics tools will most certainly turn the tide in the discovery and development of antimicrobials in this exciting field.…”
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