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1241por Ajah, Leonard Ogbonna, Ajah, Monique Iheoma, Ajah, Benjamin Okorie, Onwe, Emeka Ogah, Ozumba, Benjamin Chukwuma, Iyoke, Chukwuemeka Anthony, Nwankwo, Theophilus Ogochukwu, Ezeanya, Oguejiofo C.P.“…Measures to stop recreational drug use will be useful in stemming the tide of increasing rape cases in the state. The relevant sections of Nigerian law on rape need to be altered to broaden its scope and help punish the perpetrators in order to serve as deterrents to others. …”
Publicado 2022
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1242“…The risk model could also serve as a promising predictor for immunotherapeutic response, which has been verified by the TIDE algorithm (P < 0.05), IMvigor210 dataset (P < 0.01, n = 298), and other two datasets correlated with immunotherapy (P < 0.05, n = 56; P = 0.17, n = 27). …”
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1243“…Amid persistent power imbalances, malignant social practices may reshape one’s identity such that social isolation, whether self-imposed and/or due to restrictions from others, appear the best way to tide over overwhelming loneliness. This symposium explores how community and friendships may intercept the formation of such lonely self-identity among PLWD. …”
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1244“…The decision to leave port was only substantially affected by time of high tide at one of the four ports investigated. We measured the success of fishing trips by the landings of sea bass (kg) per metre of vessel length. …”
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1245“…The PNN low expression group had a lower tumor immune dysfunction and exclusion (TIDE) score and a higher immunophenoscore (IPS), indicating a better response to immunotherapy. …”
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1246por Inayatillah, Addina, Haigh, Ivan D., Brand, James H., Francis, Katy, Mortley, Alex, Durrant, Matthew, Fantuzzi, Laura, Palmer, Elizabeth, Miller, Callum, Hogarth, Peter“…We captured 463 years of data, from across 15 tide gauge sites, for the period 1911 to 1995. When these historical datasets are combined with digital records available from the PLA since 1995, the sea level time-series span the 111-year period from 1911 to 2021. …”
Publicado 2022
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1247por Woo, Brigitte Fong Yeong, Tam, Wilson Wai San, Rangpa, Taiju, Liau, Wei Fong, Nathania, Jennifer, Lim, Toon Wei“…The current physician-centric model of care is not sustainable for the rising tide of atrial fibrillation. The integrated model of care has been recommended for managing atrial fibrillation. …”
Publicado 2022
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1248por Tang, Yuqin, Guo, Chengbin, Yang, Zhao, Wang, Yumei, Zhang, Yongqiang, Wang, Dong“…Notably, significant differences in tumor immunogenicity and tumor immune dysfunction and exclusion (TIDE) were observed between the two risk groups, suggesting a better response to immune checkpoint blockade (ICB) therapy of the low-risk group. …”
Publicado 2022
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1249por Thomas, Luke, Underwood, Jim N., Rose, Noah H., Fuller, Zachary L., Richards, Zoe T., Dugal, Laurence, Grimaldi, Camille M., Cooke, Ira R., Palumbi, Stephen R., Gilmour, James P.“…At the Rowley Shoals in Western Australia, the prominent reef flat becomes exposed on low tide and the stagnant water in the shallow atoll lagoons heats up, creating a natural laboratory for characterizing the mechanisms of coral resilience to climate change. …”
Publicado 2022
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1250“…This critical review explores the potential dual role of a selection of NSAIDs, as an anti-inflammatory and anti-tubercular adjunct to reverse the tide of antimicrobial resistance in existing treatments.…”
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1251“…Encouragingly, according to TIDE algorithm, there were more immunotherapy responders in the low-risk IRL subgroup and the IRL score was robustly negatively linked to the immunotherapeutic response. …”
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1252“…Patients in the low-risk group showed better immunotherapy response according to TIDE and TCIA analysis, indicating that our model could effectively predict the immunotherapy response rate. …”
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1253por Pan, Shize, Meng, Heng, Fan, Tao, Hao, Bo, Song, Congkuan, Li, Donghang, Li, Ning, Geng, Qing“…In addition, the low-risk group had a better immunotherapy response with higher levels of multiple immune checkpoints and lower Tumor immune dysfunction and exclusion (TIDE) score, while the high-risk group was sensitive to multiple chemotherapeutic drugs because of its lower IC50. …”
Publicado 2022
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1254por Wang, Xin, Xu, Zhenyi, Liu, Zhilin, Lin, Weihao, Cao, Zheng, Feng, Xiaoli, Gao, Yibo, He, Jie“…The TMEscore-low subtype showed overexpression of PD-1, CTLA4, and associations of other markers of sensitivity to immunotherapy, including TMB, immunophenoscore (IPS) analysis, and tumor immune dysfunction and exclusion (TIDE) algorithm. Conclusively, TMEscore is a promising and reliable biomarker to distinguish the prognosis, the molecular and immune characteristics, and the benefit from ICIs treatments in LUAD.…”
Publicado 2022
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1255por Huang, Hua, Zhu, Guangsheng, Shi, Ruifeng, Li, Yongwen, Zhang, Zihe, Xu, Songlin, Chen, Chen, Cao, Peijun, Pan, Zhenhua, Zhang, Hongbing, Liu, Minghui, Liu, Hongyu, Chen, Jun“…Hypoxia expression profiles, immune cell infiltration, functional enrichment analysis, Tumor Immune Dysfunction and Exclusion (TIDE) score and the somatic mutation status were analyzed and compared based on the model. …”
Publicado 2022
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1256“…Methods: The transcriptome profiles of patients with prostate cancer were obtained from GEO and processed with the TIDE algorithm to predict their responses to immunotherapy. …”
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1257“…Consistently, MC2 subtype had higher T cell lytic activity and lower angiogenesis, IFNγ, T cell dysfunction, and rejection scores. TIDE analysis showed that MC2 patients were more likely to benefit from immunotherapy; MC1 patients were more sensitive to immune checkpoint inhibitors and traditional chemotherapy drugs. …”
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1258por Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.“…Using cell-based, biochemical, and modeling approaches, we studied the approved HIV-1 nucleoside/tide reverse transcriptase inhibitors (NRTIs) tenofovir (TFV) and emtricitabine (FTC), as well as prodrugs tenofovir alafenamide (TAF) and tenofovir disoproxilfumarate (TDF) for their antiviral effect against SARS-CoV-2. …”
Publicado 2022
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1259por Tao, Jian-jun, Xiang, Juan-juan, Jiang, Ming, Kuang, Su-fang, Peng, Xuan-xian, Li, Hui“…Because, as of yet, there are few new antibiotics active against multidrug-resistant bacteria are being explored, compounds including metabolites that might help us tide over this crisis are greatly expected. A recently adopted method to evaluate the potentiation of metabolites is the plate-counting test. …”
Publicado 2022
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1260“…TIMER2.0 web server and tumor immune dysfunction and exclusion (TIDE) algorithm were employed to analyze the association between our model and tumor-infiltrating immune cells and immunotherapy response. …”
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