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  1. 1641
    “…This distinct evolutionary landscape has potential to confound analytical methods developed for other genera. Against this tide of genetic drift, polymorphisms mediating functional change stand out to such an extent that evolutionary context provides a useful signal for identifying the molecular basis of drug resistance in malaria parasites, a finding that is of relevance to both genome-wide and candidate gene studies in this genus.…”
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    Protein-based signatures of functional evolution in Plasmodium falciparum
  2. 1642
    “…BACKGROUND: Young people between the ages of 15 and 24 years are both the most at risk of HIV and the greatest hope for turning the tide against HIV/AIDS. Although various surveys have been done on sexual behaviour of youth in Ethiopia, studies assessing the effect of emergency oral contraceptives on condom utilization of university students are lacking. …”
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    Effect of emergency oral contraceptive use on condom utilization and sexual risk taking behaviours among university students, Northwest Ethiopia: a cross-sectional study
  3. 1643
    “…BACKGROUND: There has been a “rising tide” in mastectomy utilization that can be attributed to more skin-sparing mastectomies (SSMs) performed concurrently with immediate breast reconstruction. …”
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    Direct to implant breast reconstruction by using SERI®, preliminary report
  4. 1644
    “…CONCLUSIONS: Although the patients carrying M204I mutation were more likely to show lack of responses to LAM therapy, LAM replacing by other nucleoside/tide analogs plus HBIG maybe still effective in decreasing hepatitis B recurrence after liver transplantation. …”
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    YMDD Motif Mutation Profile Among Patients Receiving Liver Transplant Due to Hepatitis B Virus Infection With Long Term Lamivudine/Immunoglobulin Therapy
  5. 1645
    “…There was some prior evidence in the literature to support six signals (gastroschisis and levonorgestrel/ethinylestradiol (OR 4.10, 95% CI 1.70–8.53; congenital heart disease/pulmonary valve stenosis and nucleoside/tide reverse transcriptase inhibitors (OR 5.01, 95% CI 1.99–14.20/OR 28.20, 95% CI 4.63–122.24); complete absence of a limb and pregnen (4) derivatives (OR 6.60, 95% CI 1.70–22.93); hypospadias and pregnadien derivatives (OR 1.40, 95% CI 1.10–1.76); hypospadias and synthetic ovulation stimulants (OR 1.89, 95% CI 1.28–2.70). …”
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    EUROmediCAT signal detection: an evaluation of selected congenital anomaly‐medication associations
  6. 1646
    “…Future research should investigate how tobacco control efforts can be optimised to both promote cessation and curb the rising tide of non-daily smoking in the USA.…”
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    Tobacco outlet density and converted versus native non-daily cigarette use in a national US sample
  7. 1647
    “…It has contributed significantly to the already high tide of diabetes, cardiovascular and cerebrovascular diseases. …”
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    Metabolic Profiles in Obese Children and Adolescents with Insulin Resistance
  8. 1648
    “…The results offer some valuable evidence for policy orientation in the current rising tide of the private system, including workforce development, and practitioners' role definition. …”
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    Choosing between nurse-led and medical doctor-led from private for-profit versus non-for-profit health facilities: A household survey in urban Burkina Faso
  9. 1649
    “…There is an alarming tide of cardiovascular and metabolic disease (CMD) sweeping across Africa. …”
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    Genomic and environmental risk factors for cardiometabolic diseases in Africa: methods used for Phase 1 of the AWI-Gen population cross-sectional study
  10. 1650
    “…NUC-1031, a phosphoramidate modification of gemcitabine, is the first anti-cancer ProTide to enter the clinic and is designed to overcome these key resistance mechanisms. …”
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    Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study
  11. 1651
    “…The best absolute scoring biomarkers are TIDE, one of the ICB resistance signatures and CTLA4 with a mean AUC > 0.66. …”
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    Combinations of immuno-checkpoint inhibitors predictive biomarkers only marginally improve their individual accuracy
  12. 1652
    “…BACKGROUND: Lamivudine and abacavir sulfate are widely used nucleoside/tide reverse transcriptase inhibitors (NRTI) backbone agents, which are recommended in major international treatment guidelines. …”
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    Safety and Effectiveness Analysis of Kivexa(®) (lamivudine/abacavir sulfate) in Human Immunodeficiency Virus Infected Korean Patients
  13. 1653
    “…Based on the magnitude of tide, intensity of shipping and boating activities, the stretch from Baranagar to Lalbag (278 km), located at latitude (22°38'33.41"N to 24°10'59.75"N) and longitude (88°21'21.29"E to 88°16'5.65"E) was divided into three zones viz. zone—I (Baranagar to Barrackpore), zone II (Triveni to Balagarh) and zone III (Nabadweep to Lalbag). …”
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    Impact assessment of barge trafficking on phytoplankton abundance and Chl a concentration, in River Ganga, India
  14. 1654
    “…CONCLUSIONS: RNA sequencing-based evidence from G. furcata enriched the informational database for intertidal red seaweeds which face periodic dehydration stress during the low tide period. This provided insights into an increased understanding of how ubiquitin-mediated proteolysis and the phosphatidylinositol signaling system help seaweeds responding to dehydration-rehydration cycles.…”
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    PI signal transduction and ubiquitination respond to dehydration stress in the red seaweed Gloiopeltis furcata under successive tidal cycles
  15. 1655
    “…The need to return to and/or develop new education-based models for turning the tide from the heavily return-on-investment therapeutic era of the last century into one where the investment into the preventative sciences and medicine lead to sustainable cultural and cost-effective public health and economic changes of the future is never more evident than today. …”
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    Perspectives on advancing preventative medicine through vaccinology at the comparative veterinary, human and conservation medicine interface: Not missing the opportunities
  16. 1656
    “…Patients, virally suppressed under nucleoside(d)tide analog NUC therapy, were randomized 1:1:1 across 3 dose levels (DL) and assigned to receive 10(9), 10(10), 10(11) virus particles (vp) of TG1050 and then randomized within each DL to placebo (3:1 and 9:3 vaccines/placebo in each DL, respectively, for the SD and MD cohorts). …”
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    Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
  17. 1657
    “…Looking even farther into the future, the present-day 50-year extreme water level will be exceeded almost every day during peak tide (i.e., daily mean higher high water) before the end of the 21(st) century for 90% of the U.S. coast. …”
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    Sea-level rise exponentially increases coastal flood frequency
  18. 1658
    “…Intertidal censuses and sediment collections were conducted at five different sections—Baiyu, Datan G1, Datan G2, Yongxing, and Yongan algal reefs—during the monthly spring low tide from July 2018 to January 2019. In total, 84 colonies—23 in Datan G1 and 61 in Datan G2—were recorded from a tidal range of − 160 to − 250 cm, according to the Taiwan Vertical Datum 2001 compiled by the Central Weather Bureau. …”
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    Demographic census confirms a stable population of the critically-endangered caryophyllid coral Polycyathus chaishanensis (Scleractinia; Caryophyllidae) in the Datan Algal Reef, Taiwan
  19. 1659
    “…METHODS: In this study, we used a combination of several bioinformatics tools, including WCGNA, ssGSEA, CIBERSORT, TIDE,etc., to explore significant genes both related to HPV infection status and immune cell infiltration in HNSCC patients. …”
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    HPV infection related immune infiltration gene associated therapeutic strategy and clinical outcome in HNSCC
  20. 1660
    “…Novel and potentially cost-effective therapies such as vitamin D supplementation are needed to stem the tide of TB and MDR-TB globally, particularly in India, a country that accounts for the largest fraction of the world’s TB incidence and MDR-TB incidence, and where vitamin D deficiency is endemic. …”
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    Protocol for a case–control study of vitamin D status, adult multidrug-resistant tuberculosis disease and tuberculosis infection in Mumbai, India
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