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1841“…Tumor immune dysfunction and exclusion (TIDE) analysis found that three genes were associated with immunotherapy response and maybe the potential predictors to immunotherapy, consistent with the CTR-DB database analysis. …”
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1842por Costa Alencar, Alexandre B., Selig, Wendy K. D., Geissler, Jan, Bereczky, Tamás, Ubide, Alba, Haerry, David, Stephens, Richard, Behan, Valerie“…By using innovative grant funding models, philanthropic organizations can lead the field in overcoming these challenges. Rising Tide Foundation for Clinical Cancer Research (RTFCCR), a private philanthropy that funds academic research, has developed a novel approach for requiring and supporting partnerships among grantees and patients in designing and conducting research projects. …”
Publicado 2023
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1843por Maimaiti, Aierpati, Feng, Zhaohai, Liu, Yanwen, Turhon, Mirzat, Xie, Zhihao, Baihetiyaer, Yilimire, Wang, Xixian, Kasimu, Maimaitijiang, Jiang, Lei, Wang, Yongxin, Wang, Zengliang, Pei, Yinan“…We used gene set enrichment analysis (GSEA), single sample GSEA (ssGSEA), CIBERSORT algorithm, ESTIMATE algorithm, and TIDE to evaluate the association between m7G modification patterns, tumor microenvironment (TME) cell infiltration properties, and immune infiltration markers. …”
Publicado 2023
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1844por Ding, Chengsheng, Yang, Xiao, Li, Shuchun, Zhang, Enkui, Fan, Xiaodong, Huang, Ling, He, Zirui, Sun, Jing, Ma, Junjun, Zang, Lu, Zheng, Minhua“…Then, the responses to chemotherapy and immunotherapy were predicted by pRRophetic algorithm, the tumor immune dysfunction and exclusion (TIDE) and SubMap algorithms, respectively. Moreover, the Cancer Therapeutics Response Portal (CTRP) and PRISM Repurposing dataset (PRISM) were used to explore novel drug treatment strategies of CRC. …”
Publicado 2023
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1845“…Tumor Immune Dysfunction and Exclusion (TIDE) and Immunophenotype Score (IPS) were used to evaluate the immunotherapy response. …”
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1846por Xu, Xiaoping, Zhou, Shijun, Tao, Yuchuan, Zhong, Zhenglan, Shao, Yongxiang, Yi, Yong“…Furthermore, the sensitivity of patients to immune checkpoint inhibitor (ICI) treatment based on the prognostic feature was predicted with the assistance of the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm. Finally, qRT-PCR was used to verify the difference in the expression of the lncRNAs in glioma cells and normal cell. …”
Publicado 2023
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1847“…The response to chemotherapy and immunotherapy was predicted via GDSC dataset and TIDE algorithm, respectively. R packages were employed to explore the relationship between SNX7 expression and immune infiltration, m6A modification, as well as the functional enrichment of differentially expressed genes (DEGs). …”
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1848por Shen, Chong, Chai, Wang, Han, Jingwen, Zhang, Zhe, Liu, Xuejing, Yang, Shaobo, Wang, Yinlei, Wang, Donghuai, Wan, Fangxin, Fan, Zhenqian, Hu, Hailong“…The potential response to ICB therapy was estimated using the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm and Immunophenoscore (IPS). Additionally, it was found that the expression level of certain genes in the model was significantly correlated with objective responses to anti-PD-1 or anti-PD-L1 treatment in the IMvigor210, GSE111636, GSE176307, or Truce01 (registration number NCT04730219) cohorts. …”
Publicado 2023
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1849“…Finally, Tumor Immune Dysfunction and Exclusion (TIDE) algorithms was utilized to predict the response to immunotherapy. …”
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1850por Tashima, Karen, Crofoot, Gordon, Tomaka, Frank L, Kakuda, Thomas N, Brochot, Anne, Van de Casteele, Tom, Opsomer, Magda, Garner, William, Margot, Nicolas, Custodio, Joseph M, Fordyce, Marshall W, Szwarcberg, Javier“…METHODS: This 48-week, Phase IIIb, single-arm, US multicenter study (NCT01440569) evaluated safety, efficacy and pharmacokinetics of darunavir/cobicistat 800/150 mg once daily (as single agents) plus two investigator-selected nucleoside/tide reverse transcriptase inhibitors (N[t]RTIs) in HIV-1-infected adults. …”
Publicado 2014
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1851por Zhang, Jinjia, Gao, Yiyang, Li, Yongze, Teng, Di, Xue, Yuanming, Yan, Li, Yang, Jing, Yang, Lihui, Yao, Yongli, Ba, Jianming, Chen, Bing, Du, Jianling, He, Lanjie, Lai, Xiaoyang, Teng, Xiaochun, Shi, Xiaoguang, Li, Yanbo, Chi, Haiyi, Liao, Eryuan, Liu, Chao, Liu, Libin, Qin, Guijun, Qin, Yingfen, Quan, Huibiao, Shi, Bingyin, Sun, Hui, Tang, Xulei, Tong, Nanwei, Wang, Guixia, Zhang, Jin-an, Wang, Youmin, Ye, Zhen, Zhang, Qiao, Zhang, Lihui, Zhu, Jun, Zhu, Mei, Teng, Weiping, Shan, Zhongyan, Li, Jing“…Methods: The data of this study were derived from the Thyroid Disease, Iodine status, and Diabetes National epidemiological (TIDE) survey from all 31 provinces of mainland China. …”
Publicado 2020
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1852por Luo, Zhiwen, Chen, Xiao, Zhang, Yefan, Huang, Zhen, Zhao, Hong, Zhao, Jianjun, Li, Zhiyu, Zhou, Jianguo, Liu, Jianmei, Cai, Jianqiang, Bi, Xinyu“…Additionally, the Tumor Immune Dysfunction and Exclusion (TIDE) algorithm and GDSC analysis suggested the IPM-low as a promising responder to anti-CTLA-4 therapy and the common FDA-targeted drugs, while the IPM-high was non-responsive to these treatments. …”
Publicado 2021
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1853“…Immune infiltration was estimated by TIMER, TIDE, CIBERSORT, CIBERSORT-ABS, QUANTISEQ, XCELL, MCPCOUNTER, and EPIC algorithms. …”
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1854por Xu, Wenhao, Tao, Juli, Zhu, Wenkai, Liu, Wangrui, Anwaier, Aihetaimujiang, Tian, Xi, Su, Jiaqi, Shi, Guohai, Huang, Haineng, Wei, Gaomeng, Li, Chuanyu, Qu, Yuanyuan, Zhang, Hailiang, Ye, Dingwei“…Interestingly, large-scale pan-cancer samples (n = 12,521) and three single-cell RNA datasets revealed that RBCK1 showed markedly differential expression between cancer and normal tissues and significantly correlated with tumor-infiltrating immune cells, tumor purity, and immune checkpoint molecules, such as PD-L1, CTLA-4, LAG-3, and TIGIT in pan-cancer samples. Notably, the TIDE score was significantly higher in the RBCK1(high) group compared with the RBCK1(low) group in both ccRCC and RCC cohorts. …”
Publicado 2021
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1855por Xian, Haocheng, Li, Yuan, Zou, Boliang, Chen, Yajuan, Yin, Houqing, Li, Xuejun, Pan, Yan“…The functional enrichment analysis was performed using the “ClusterProfiler” R package, and the correlation of key clock genes with tumor mutation burden, immune checkpoint, and immune infiltration levels were also assessed using multiple algorithms including TIDE, TIMER2.0, and XCELL. RESULTS: TIMELESS was significantly upregulated in lung tissue of clinical lung cancer patients as well as TCGA and Oncomine databases, while RORA was downregulated. …”
Publicado 2022
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1856“…Single-sample gene set enrichment (ssGSEA) algorithm and Tumor Immune Dysfunction and Exclusion (TIDE) analysis confirmed that this signature influence tumour microenvironment and immune checkpoint blockade. …”
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1857por Lau, Mai Chan, Yi, Yang, Goh, Denise, Cheung, Chun Chau Lawrence, Tan, Benedict, Lim, Jeffrey Chun Tatt, Joseph, Craig Ryan, Wee, Felicia, Lee, Justina Nadia, Lim, Xinru, Lim, Chun Jye, Leow, Wei Qiang, Lee, Jing Yi, Ng, Cedric Chuan Young, Bashiri, Hamed, Cheow, Peng Chung, Chan, Chun Yip, Koh, Ye Xin, Tan, Thuan Tong, Kalimuddin, Shirin, Tai, Wai Meng David, Ng, Jia Lin, Low, Jenny Guek-Hong, Lim, Tony Kiat Hon, Liu, Jin, Yeong, Joe Poh Sheng“…In addition, tumor immune dysfunction and exclusion (TIDE) analysis revealed marked T cell dysfunction and inflammation, alongside low T cell exclusion and M2 tumor-associated macrophage infiltration. …”
Publicado 2022
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1858“…Single sample gene set enrichment analysis (ssGSEA), immune checkpoints, m6A-related genes, tumor mutation burden (TMB), stem cell correlation, tumor immune dysfunction and rejection (TIDE) scores and drug sensitivity are also used to study the risk model. …”
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1859por Peng, Zesheng, Wu, Yuxi, Wang, Jiajing, Gu, Sujie, Wang, Yihao, Xue, Bingzhou, Fu, Peng, Xiang, Wei“…Tumor Immune Dysfunction and Exclusion (TIDE) showed that the high GA-MSCRGPI group had more responders to ICI therapy. …”
Publicado 2023
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1860“…The Tumor mutational burden and Tumor Immune Dysfunction and Rejection (TIDE) were used to analyze immunotherapeutic efficiency. …”
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