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  1. 281
    “…BACKGROUND: A systematic review and meta-analysis were performed to investigate the efficacy and safety of conversion from calcineurin inhibitors (CNIs) to mammalian target of rapamycin inhibitors (mTORi) in kidney transplant recipients (KTRs). METHODS: MEDLINE, EMBASE, PubMed, and Cochrane Library were searched to identify randomized controlled trials (RCTs) that compared the continuation of CNI with conversion to mTORi therapy. …”
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    Conversion From Calcineurin Inhibitors to Mammalian Target of Rapamycin Inhibitors in Kidney Transplant Recipients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
  2. 282
    “…Thanks to all the basic, translational and clinical research achieved in the last twenty years, we now use mTORi as de novo immunosuppression in association with CNI. …”
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    Medical Aspects of mTOR Inhibition in Kidney Transplantation
  3. 283
    “…Mammalian target of rapamycin inhibitors (mTORi) are used to treat a variety of malignancies and have an established role in organ transplantation. …”
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    Sirolimus-induced interstitial lung disease and resolution after conversion to everolimus
  4. 284
    “…Limited data suggest that the use of CNI or mTORi may have beneficial effects on the process. …”
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    Effect of Calcineurin Inhibitors and Mammalian Target of Rapamycin Inhibitors on the Course of COVID-19 in Kidney Transplant Recipients
  5. 285
    “…T-cell number only significantly increased in those KTRs where CNI was ceased as part of the conversion to mammalian target of rapamycin inhibitors (mTORi's) (P = 0.031) implying CNI cessation rather than mTORi initiation induced an increase in T-cell number. …”
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    Conversion to sirolimus in kidney transplant recipients with squamous cell cancer and changes in immune phenotype
  6. 286
    “…We show that twisted doubled tori can be used to construct a general class of worldsheet models describing non-geometric string backgrounds. …”
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    Worldsheet theories for non-geometric string backgrounds
  7. 287
    por Lujan, David, Scheeres, Daniel J.
    Publicado 2023
    “…The first two types of orbits are 2-dimensional quasi-periodic tori, whereas the elliptic orbits are 3-dimensional quasi-periodic tori. …”
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    Dynamics in the Vicinity of the Stable Halo Orbits
  8. 288
    “…This monograph presents some theoretical and computational aspects of the parameterization method for invariant manifolds, focusing on the following contexts: invariant manifolds associated with fixed points, invariant tori in quasi-periodically forced systems, invariant tori in Hamiltonian systems and normally hyperbolic invariant manifolds. …”
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    The parameterization method for invariant manifolds: from rigorous results to effective computations
  9. 289
    por Hanβmann, Heinz
    Publicado 2007
    “…While elliptic and hyperbolic tori determine the distribution of maximal invariant tori, they themselves form n-parameter families. …”
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    Local and semi-local bifurcations in Hamiltonian dynamical systems
  10. 290
    “…BACKGROUND: Chromosomal rearrangements are common in clear cell renal cell carcinoma (ccRCC) and their roles in mediating sensitivity to tyrosine kinase inhibitors (TKIs) and mTOR inhibitors (mTORi) remain elusive. METHODS: We developed an in silico strategy by screening copy number variance (CNV) that was potentially related to TKI or mTORi sensitivity in ccRCC by reproducing the TCGA and GDSC datasets. …”
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    Comprehensive analysis of copy number variance and sensitivity to common targeted therapy in clear cell renal cell carcinoma: In silico analysis with in vitro validation
  11. 291
    por Dimitrova, Dimana, Nademi, Zohreh, Maccari, Maria Elena, Ehl, Stephan, Uzel, Gulbu, Tomoda, Takahiro, Okano, Tsubasa, Imai, Kohsuke, Carpenter, Benjamin, Ip, Winnie, Rao, Kanchan, Worth, Austen J. J., Laberko, Alexandra, Mukhina, Anna, Néven, Bénédicte, Moshous, Despina, Speckmann, Carsten, Warnatz, Klaus, Wehr, Claudia, Abolhassani, Hassan, Aghamohammadi, Asghar, Bleesing, Jacob J., Dara, Jasmeen, Dvorak, Christopher C., Ghosh, Sujal, Kang, Hyoung Jin, Markelj, Gašper, Modi, Arunkumar, Bayer, Diana K., Notarangelo, Luigi D., Schulz, Ansgar, Garcia-Prat, Marina, Soler-Palacín, Pere, Karakükcü, Musa, Yilmaz, Ebru, Gambineri, Eleonora, Menconi, Mariacristina, Masmas, Tania N., Holm, Mette, Bonfim, Carmem, Prando, Carolina, Hughes, Stephen, Jolles, Stephen, Morris, Emma C., Kapoor, Neena, Koltan, Sylwia, Paneesha, Shankara, Steward, Colin, Wynn, Robert, Duffner, Ulrich, Gennery, Andrew R., Lankester, Arjan C., Slatter, Mary, Kanakry, Jennifer A.
    Publicado 2022
    “…The 2-year cumulative incidence of graft failure following first HCT was 17% overall but 42% if mammalian target of rapamycin inhibitor(s) (mTORi) were used in the first year post-HCT, compared with 9% without mTORi. …”
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    International retrospective study of allogeneic hematopoietic cell transplantation for activated PI3K-delta syndrome
  12. 292
    “…Regarding immunosuppression of full ABMR + DSA+ and controls, 21 biopsies were performed under mTORi treatment (11 of them ABMR + DSA+ cases) and 43 without mTORi (20 of them ABMR + DSA+) so as to explore its effect on the mTOR pathway. …”
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    Phosphorylation of S6RP in peritubular capillaries of kidney grafts and circulating HLA donor-specific antibodies
  13. 293
    por Voskresenskiĭ, V E
    Publicado 2011
    “…This book--which can be viewed as a significant revision of the author's book, Algebraic Tori (Nauka, Moscow, 1977)--studies birational properties of linear algebraic groups focusing on arithmetic applications. …”
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    Algebraic groups and their birational invariants
  14. 294
    “…It is crucial to keep in mind that every case presented had a history of palatal tori. In our clinical observations, higher precedence of ABE development was seen in participants during incisor retraction, especially with preexisting palatal tori. …”
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    Alveolar bone exostoses following orthodontic treatment. Diagnostic considerations and clinical management
  15. 295
    “…This review aims to summarize the roles of mTORi in managing patients with HCC undergoing LT. …”
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    The Role of mTOR Inhibitors after Liver Transplantation for Hepatocellular Carcinoma
  16. 296
    “…The use of mTOR inhibitors (mTORi) for immunosuppression after LT for HCC has been proposed due to rapamycin antitumor activity. …”
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    Oncological Impact of M-Tor Inhibitor Immunosuppressive Therapy after Liver Transplantation for Hepatocellular Carcinoma: Review of the Literature
  17. 297
    “…INTRODUCTION AND IMPORTANCE: Tori are benign bony outgrowths that occur in different locations along the mandible and maxilla. …”
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    Early recurrence of mandibular torus following surgical resection: A case report
  18. 298
    “…Our findings reveal a critical role of RSK3 induction in tumor survival upon BET inhibition and warrant further evaluation of the combination of mTORis and BETis in patients with SCLC.…”
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    mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer
  19. 299
    “…Patients receiving a second-line therapy (median overall survival 27.6 months) and those patients with three or more lines of therapy (43.8 months) have the greatest benefit. Also, exposure to a mTORi improves survival versus non-exposure to mTORi (63.3 vs. 22.3 months, p=0.038). …”
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    Treatment, Outcome and Prognostic Factors in Renal Cell Carcinoma - A Single Center Study (2000-2010)
  20. 300
    “…To circumvent acquired resistance, we show potency of combinatorial targeting with trametinib and everolimus, an mTOR inhibitor (mTORi) against multiple BRAF-fusions. While single-agent mTORi and MEKi PLGG clinical trials are underway, our study provides preclinical rationales for using MEKi and mTORi combinatorial therapy to stave off or prevent emergent drug-resistance in BRAF-fusion driven PLGGs.…”
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    Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways
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