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  1. 301
    “…In vitro evaluation confirmed the dose-dependent effect of mTORi, i.e., rapamycin, on fibrotic markers in ureteral component cell lines. …”
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    Biodegradable Stent with mTOR Inhibitor-Eluting Reduces Progression of Ureteral Stricture
  2. 302
    “…CONCLUSIONS: Real-world studies employed different designs and reported heterogeneous results comparing the effectiveness of second-line mTORi and VEGF TKI in the treatment of mRCC. Within the subset of adjusted, multicenter observational studies, second-line use of mTORi was associated with significantly prolonged survival compared with second-line use of VEGF TKI.…”
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    Comparative Effectiveness of Second-Line Targeted Therapies for Metastatic Renal Cell Carcinoma: A Systematic Review and Meta-Analysis of Real-World Observational Studies
  3. 303
    “…Despite efforts, mTOR inhibitors (mTORi) have produced limited response clinically, partly due to incomplete knowledge of mTORC1 addiction in cancers. …”
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    Hippocalcin-Like 1 blunts liver lipid metabolism to suppress tumorigenesis via directly targeting RUVBL1-mTOR signaling
  4. 304
    “…Compared to the generalized metric formulation of DFT derived from tori, all these quantities receive additional contributions related to the non-trivial background. …”
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    Generalized Metric Formulation of Double Field Theory on Group Manifolds
  5. 305
    por Dall'Agata, G, Prezas, N
    Publicado 2005
    “…Subsequently, we explore the landscape of vacua of M-theory compactifications on twisted tori, where we emphasize the role of geometric fluxes and discuss the validity of the bottom-up approach. …”
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    Scherk-Schwarz reduction of M-theory on G2-manifolds with fluxes
  6. 306
    “…In the present study, we mitigated the effects of IR-induced inflammatory EVs (i.e., TNF-α), through the use of mTOR inhibitors (mTORi; Rapamycin and INK128). Further, mTORi were found to enhance the selective killing of HIV-1-infected myeloid and T-cell reservoirs at the exclusion of uninfected cells, potentially via inhibition of viral transcription/translation and induction of autophagy. …”
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    Low-Level Ionizing Radiation Induces Selective Killing of HIV-1-Infected Cells with Reversal of Cytokine Induction Using mTOR Inhibitors
  7. 307
    “…These findings suggest humoral immune response benefits of switching the standard immunosuppressive regimen to the regimen of mTORi, TAC, and prednisolone in KTRs during vaccination.…”
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    Benefits of Switching Mycophenolic Acid to Sirolimus on Serological Response after a SARS-CoV-2 Booster Dose among Kidney Transplant Recipients: A Pilot Study
  8. 308
    por Pepe, Alberto, Kurtz, Michael J.
    Publicado 2012
    “…The proposed measures of research impact, tori and riq, have been implemented in the Smithsonian/NASA Astrophysics Data System.…”
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    A Measure of Total Research Impact Independent of Time and Discipline
  9. 309
    “…Inhibitors of the mammalian target of rapamycin (mTORi) have clinical activity; however, the benefits of mTOR inhibition by rapamycin and rapamycin-derivatives (rapalogs) may be limited by a feedback mechanism that results in AKT activation. …”
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    Arsenic Trioxide Overcomes Rapamycin-Induced Feedback Activation of AKT and ERK Signaling to Enhance the Anti-Tumor Effects in Breast Cancer
  10. 310
    “…Both small molecule inhibitors and shRNAs targeting YAP1 or Src overcame the MAPKi and PI3K/mTORi dual-drug resistance. In conclusion, our data not only illuminated an integrin-Src-YAP1 pathway mediated MAPKi and PI3K/mTORi dual-drug resistant mechanism but also provided a potential combinatorial regimen for the drug-relapsed melanoma patients.…”
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    Integrin-Src-YAP1 signaling mediates the melanoma acquired resistance to MAPK and PI3K/mTOR dual targeted therapy
  11. 311
    “…Within the scope of investigated immunotherapy (IO) combinations, toripalimab + FfCT (tori + FfCT) demonstrated the best OS advantages (tori + FfCT vs. …”
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    Efficacy and safety of immunochemotherapy, immunotherapy, chemotherapy, and targeted therapy as first-line treatment for advanced and metastatic esophageal cancer: a systematic review and network meta-analysis
  12. 312
    por Everts, Jeffrey C., Ravnik, Miha
    Publicado 2018
    “…Here, we show that electric double layers of non-trivial topology and geometry -including tori, multi-tori and knots- can be realised in charged topological colloidal particles, using numerical modelling within a mean-field Poisson-Boltzmann theory. …”
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    Complex electric double layers in charged topological colloids
  13. 313
    “…Last, we studied mTORi-NB biodistribution in nonhuman primates by PET/MR imaging and evaluated its safety, paving the way for clinical translation.…”
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    A modular approach toward producing nanotherapeutics targeting the innate immune system
  14. 314
    por Marchioro, Carlo
    Publicado 2011
    “…Chenciner - Hopf bifurcation for invariant tori; and, M. Misiurewicz - Horseshoes for continuous mappings of an interval.…”
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    Dynamical Systems
  15. 315
    “…Moreover, we demonstrate that combining MEK inhibitors (MEKi) with dual PI3K/mTOR inhibitors (PI3K/mTORi) resulted in a super-additive suppression of melanocyte hyperplasia. …”
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    Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics
  16. 316
    “…Exhaustive searches show that, for small-sized tori, each of the proposed schemes produces an optimal solution to the corresponding subproblem. …”
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    Reducing the Spectral Radius of a Torus Network by Link Removal
  17. 317
    “…Clinic endoscopic exam demonstrated severe inflammatory and cystic changes lining the bilateral tori. Imaging and tissue sampling confirmed the cause was minor salivary gland cysts with papillary projections lined by oncocytic cells within bilateral tori tubarius. …”
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    Oncocytic Cysts of the Nasopharynx: A Case Report
  18. 318
    “…NF-κB-driven transcriptional activity is enhanced with LPS stimulation after mTORi treatment to increase expression of F3 (TF). …”
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    mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses
  19. 319
    “…Evaluation of camizestrant in combination with CDK4/6i (palbociclib or abemaciclib) in CDK4/6-naive and -resistant models, as well as in combination with PI3Kαi (alpelisib), mTORi (everolimus), or AKTi (capivasertib), indicated that camizestrant was active with CDK4/6i or PI3K/AKT/mTORi and that antitumor activity was further increased by the triple combination. …”
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    The Next-Generation Oral Selective Estrogen Receptor Degrader Camizestrant (AZD9833) Suppresses ER(+) Breast Cancer Growth and Overcomes Endocrine and CDK4/6 Inhibitor Resistance
  20. 320
    “…By months 7 to 12, immunosuppression regimens were more commonly antimetabolite sparing (33.7%) or steroid sparing (26.9%), followed by triple (14.4%), mammalian target of rapamycin inhibitor (mTORi)-based (12.1%), or cyclosporine-based (9.2%). …”
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    Center-driven and Clinically Driven Variation in US Liver Transplant Maintenance Immunosuppression Therapy: A National Practice Patterns Analysis
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