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101“…In this report we have defined the elements of a workflow for SA of PBPK models that is computationally feasible, accounts for interactions between parameters, and can be displayed in the form of a bar chart and cumulative sum line (Lowry plot), which we believe is intuitive and appropriate for toxicologists, risk assessors, and regulators.…”
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102“…In this review, we summarize the current resources in the literature in regard to TGx studies of the liver, from which toxicologists could extract potential TGx biomarker gene sets for better hepatotoxicity risk assessment.…”
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103por Orisakwe, Orish Ebere“…Should environmental lead and cadmium be implicated in the etiogenesis of psychiatry given the characteristic high environmental pollution in Sub Sahara Africa, it is worthwhile for toxicologists and scientists in Sub-Sahara Africa to investigate if lead and cadmium can become additional biomarkers in the diagnosis of psychiatric disorders.…”
Publicado 2014
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104por Mladěnka, Přemysl, Applová, Lenka, Patočka, Jiří, Costa, Vera Marisa, Remiao, Fernando, Pourová, Jana, Mladěnka, Aleš, Karlíčková, Jana, Jahodář, Luděk, Vopršalová, Marie, Varner, Kurt J., Štěrba, Martin“…Due to the large number of clinically relevant compounds discussed, this article could be of interest to a broad audience including pharmacologists and toxicologists, pharmacists, physicians, and medicinal chemists. …”
Publicado 2018
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105“…The goal is to provide toxicologists an up to date review on the creation of genetically engineered animal models, which can be used to model genetic susceptibility to disease.…”
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106“…Adverse Outcome Pathways (AOPs) are a research synthesis tool, used primarily by toxicologists for numerous applications including: hypothesis generation, data integration, biomarker determination, and identification of gaps in current knowledge. …”
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107por Argo, Antonina, Zerbo, Stefania, Buscemi, Roberto, Trignano, Claudia, Bertol, Elisabetta, Albano, Giuseppe Davide, Vaiano, Fabio“…The presented diagnostic algorithm provides the coroner with all the elements to investigate drug-related deaths and cooperate with toxicologists. Toxicological forensic diagnosis is still extremely heterogeneous in regional and national contexts. …”
Publicado 2022
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108por Kirkland, D J“…Environmental Mutagen Society decided to address this omission, and in 1985 established 8 working groups comprising genetic toxicologists from all sectors of the science, plus at least 2 statisticians per group, to produce statistics guidelines on 10 different test systems. …”
Publicado 1994
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109“…The recent technological revolution in the field of imaging techniques has provided pathologists and toxicologists with an expanding repertoire of analytical techniques for studying the interaction between the lung and the various exogenous materials to which it is exposed. …”
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110“…Much lower levels were found in all the other food types analyzed; of these, the highest levels found were a mean level of 0.08 ppm in chicken and 0.16 ppm in rice. FDA toxicologists do not believe that the average daily intake of arsenic, or its levels in the different food commodities, pose a hazard to the consumer.…”
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111por Ward, Elizabeth M, Schulte, Paul A, Bayard, Steve, Blair, Aaron, Brandt-Rauf, Paul, Butler, Mary Ann, Dankovic, David, Hubbs, Ann F, Jones, Carol, Karstadt, Myra, Kedderis, Gregory L, Melnick, Ronald, Redlich, Carrie A, Rothman, Nathaniel, Savage, Russell E, Sprinker, Michael, Toraason, Mark, Weston, Ainsley, Olshan, Andrew F, Stewart, Patricia, Zahm, Sheila Hoar“…Progress in occupational cancer will require interdisciplinary research involving epidemiologists, industrial hygienists, toxicologists, and molecular biologists.…”
Publicado 2003
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112“…The recent accumulation of toxicity-associated gene sets (toxicogenomic biomarkers), enrichment in public or commercial large-scale microarray database and availability of open-source software resources facilitate our utilization of the toxicogenomic data. However, toxicologists, who are usually not experts in computational sciences, tend to be overwhelmed by the gigantic amount of data. …”
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113por Sabatini, Diletta, Truscelli, Giovanni, Ciccaglioni, Antonio, Gaudio, Carlo, Grassi, Maria Caterina“…This case shows that a multiple disciplinary approach, involving cardiologists and toxicologists, is essential for the management of digoxin intoxication. …”
Publicado 2014
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114por Gonçalves, Joana, Rosado, Tiago, Soares, Sofia, Simão, Ana Y., Caramelo, Débora, Luís, Ângelo, Fernández, Nicolás, Barroso, Mário, Gallardo, Eugenia, Duarte, Ana Paula“…There will be also a focus on the analytical methodologies for their analysis, in order to aid health professionals and toxicologists in cases where these compounds are present.…”
Publicado 2019
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115por Bolcato, Vittorio, Carelli, Claudia, Radogna, Alessandra, Freni, Francesca, Moretti, Matteo, Morini, Luca“…The analysis of psychoactive substances in hair is of great importance for both clinical and forensic toxicologists since it allows one to evaluate past and continuative exposure to xenobiotics. …”
Publicado 2021
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116por Colman, Karyn, Andrews, Rachel N., Atkins, Hannah, Boulineau, Theresa, Bradley, Alys, Braendli-Baiocco, Annamaria, Capobianco, Raffaella, Caudell, David, Cline, Mark, Doi, Takuya, Ernst, Rainer, van Esch, Eric, Everitt, Jeffrey, Fant, Pierluigi, Gruebbel, Margarita M., Mecklenburg, Lars, Miller, Andew D., Nikula, Kristen J., Satake, Shigeru, Schwartz, Julie, Sharma, Alok, Shimoi, Akihito, Sobry, Cécile, Taylor, Ian, Vemireddi, Vimala, Vidal, Justin, Wood, Charles, Vahle, John L.“…A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.…”
Publicado 2021
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117por Bradley, Alys E, Wancket, Lyn Miller, Rinke, Matthias, Gruebbel, Margarita M, Saladino, Brett H., Schafer, Kenneth, Katsuta, Osamu, Garcia, Begonya, Chanut, Franck, Hughes, Katherine, Nelson, Keith, Himmel, Lauren, McInnes, Elizabeth, Schucker, Adrienne, Uchida, Kazuyuki“…A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.…”
Publicado 2021
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118“…Outside the United States, toxicologists and regulators clearly have a growing interest in the toxicology and risk assessment of chemical mixtures.…”
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119“…Both methods display high performance on the NR-DBIND set and could serve as starting point for biologists and toxicologists. Yet, the pharmacophore models still need data feeding to be used as large scope undesired effect prediction models.…”
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120por Martí-Clúa, Joaquín“…It may be used as a reference for toxicologists and neurobiologists given the broad use of 5-bromo-2′-deoxyuridine to label dividing cells.…”
Publicado 2021
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