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“…Experimental research has always been the cornerstone of pathophysiological and therapeutic advances in critical care medicine, where clinical observations and basic research mutually fed each other in a so-called translational approach. The objective of this review is to address the different aspects of translational research in the field of critical care medicine. …”
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“…mRNA is translated with a non-uniform speed that actively coordinates co-translational folding of protein domains. …”
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“…More specifically, the alcohols target translation initiation, a complex stage of the gene expression process. …”
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“…Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identification of which gene(s) within regions of association are causal for a disease or phenotypic trait; the narrowing down of the cell types or regulators involved in the etiology of disease; the characterization of drivers and modifiers of cancer; and our understanding of how different environments and cellular contexts can modify gene expression. …”
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“…The contribution of regulation of mRNA translation during myogenesis has not been studied so far. …”
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“…Here we report on the effect of the commonly known RNA base-lesions 8-oxo-rG, 8-oxo-rA, ε-rC, ε-rA, 5-HO-rC, 5-HO-rU and the RNA abasic site (rAS) on ribosomal translation. To this end we have developed an in vitro translation assay based on the mRNA display methodology. …”
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“…The rapid increase in knowledge and reduced cost of sequencing translate to new and additional approaches to clinical care. …”
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“…Cells can survive hypoxia/anoxia by metabolic rate depression, which involves lowering of mRNA translation rates in an ATP-dependent manner. By activating anaerobic ATP production (glycolysis), the inhibitory influence on mRNA translation in hypoxia can be abolished. …”
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“…This commentary will highlight this work and provide a rationale for the continued importance of translational work in the field of targeted melanoma therapies.…”
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“…Ethnodrama is an innovative knowledge translation strategy that uses theatrical performances for dissemination of research results. …”
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“…Together, these results illustrate that ATM deficiency causes impaired initiation of protein translation in BM, leading to immature development of DC.…”
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“…The systems biology omics technologies (transcriptomics, proteomics and metabolomics) have been used to discover potential translational biomarkers of liver injury. The following review provides a summary of the systems biology discovery process, analytical validation of biomarkers and translation of omics biomarkers from the nonclinical to clinical setting in APAP-induced liver injury.…”
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“…We describe a gene regulatory mechanism that is based on polyadenylate [poly(A)] tracks that stall the translation apparatus. We show that creating longer or shorter runs of adenosine nucleotides, without changes in the amino acid sequence, alters the protein output and the stability of mRNA. …”
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“…Translational regulation is mediated through the interaction between diffusible trans-factors and cis-elements residing within mRNA transcripts. …”
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