“…This approach reveals a surprising heterogeneity in the translation of individual mRNAs within the same cell, including rapid and reversible transitions between a translating and non-translating state. …”
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“…The evolution of medicine and medical technology hinges on the successful translation of basic science research from the bench to clinical implementation at the bedside. …”
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“…Here we investigate responses of three transformation media under electromagnetic pulses, and find that pulse radiation can induce unbalanced net force on transformation media, which will cause translation and rotation of transformation media although their final momentum can still be zero. …”
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“…Local mRNA translation mediates the adaptive responses of axons to extrinsic signals, but direct evidence that it occurs in mammalian CNS axons in vivo is scant. …”
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“…Programmed changes in mRNA abundance make a strong contribution to the developmental shifts in protein output, but output is further adjusted by changes in translational efficiency. RNAs with prioritized translation early in development are largely involved in chloroplast gene expression, whereas those with prioritized translation in photosynthetic tissues are generally involved in photosynthesis. …”
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“…Translational readthrough (TR) has come into renewed focus because systems biology approaches have identified the first human genes undergoing functional translational readthrough (FTR). …”
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“…Large-radius translation invariant (TI) bipolarons are considered in a one-dimensional Holstein molecular chain. …”
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“…More broadly, epistemology is about issues having to do with the creation and dissemination of knowledge in particular areas of inquiry as defned and revisiting at the beginning of the last decades. Translational medicine (TM) should meet the demands to maintain or expanding the biomedical workforce and education programs that attract and retain young people in the translational and biomedical sciences. …”
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“…The Framework To Assess the Impact from Translational health research, or FAIT, is a platform designed to prospectively measure and encourage research translation and research impact. …”
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“…The stapled ribosome is directed to an orthogonal mRNA, allowing the introduction of mutations into the large subunit that reduce orthogonal translation, but have minimal effects on cell growth. …”
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“…Given the high mutation rate of viruses relative to the timescales of host evolution and drug development, novel drug classes that are readily screened and translated to the clinic are needed. RNA interference (RNAi)—a natural mechanism for specific degradation of target RNAs that is conserved from plants to invertebrates and vertebrates—can potentially be harnessed to yield therapies with extensive specificity, ease of design, and broad application. …”
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“…In the absence of EF-P, the presence of Rho utilization (rut) sites led to an ~30-fold decrease in translation of polyproline-encoding mRNAs. Coexpression of the Rho inhibitor Psu fully restored translation. …”
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“…Lastly, we describe the specific synthetic lethal interactions identified in lung cancer to date and explore the pharmacological challenges and considerations in translating these discoveries to the clinic.…”
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“…Selection of the correct start codon during initiation of translation on the ribosome is a key event in protein synthesis. …”
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“…The newly generated reference sequences of unstudied minor plants can be annotated by the knowledge of model plants via translational genomics approaches. Here, we reviewed the strategies of translational genomics and suggested perspectives on the current databases of genomic resources and the database structures of translated information on the new genome. …”
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“…AIM: This paper presents a discussion of the role of the philosophy of pragmatism in the integrated knowledge translation approach to research. DESIGN: Critical inquiry is used to discuss bringing pragmatic philosophy and the integrated knowledge translation approach to research together to advance nursing knowledge. …”
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“…The scalability of thermal fibre drawing approach offers access to large device quantities, while constraining the devices to be translational symmetric. Lifting this symmetry to create discrete devices in fibres will increase their utility. …”
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